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Protein

Pantothenate kinase 3

Gene

PANK3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by CoA and its thioesters.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (PANK4), Pantothenate kinase 3 (PANK3), Pantothenate kinase 4 (PANK4)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192Acetyl-CoABy similarity1
Binding sitei195Acetyl-CoABy similarity1
Binding sitei207Acetyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-196783 Coenzyme A biosynthesis
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase 3 (EC:2.7.1.33)
Alternative name(s):
Pantothenic acid kinase 3
Gene namesi
Name:PANK3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:32565 PANK3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002613561 – 370Pantothenate kinase 3Add BLAST370

Proteomic databases

PaxDbiQ08DA5
PRIDEiQ08DA5

Expressioni

Gene expression databases

BgeeiENSBTAG00000011895

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015780

Structurei

3D structure databases

ProteinModelPortaliQ08DA5
SMRiQ08DA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2201 Eukaryota
COG5146 LUCA
GeneTreeiENSGT00390000020719
HOGENOMiHOG000194690
HOVERGENiHBG053495
InParanoidiQ08DA5
KOiK09680
OMAiHDLPTFI
OrthoDBiEOG091G0851
TreeFamiTF314866

Family and domain databases

InterProiView protein in InterPro
IPR004567 Type_II_PanK
PfamiView protein in Pfam
PF03630 Fumble, 1 hit
TIGRFAMsiTIGR00555 panK_eukar, 1 hit

Sequencei

Sequence statusi: Complete.

Q08DA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKDAKKPS FPWFGMDIGG TLVKLSYFEP IDITAEEEQE EVESLKSIRK
60 70 80 90 100
YLTSNVAYGS TGIRDVHLEL KDLTLFGRRG NLHFIRFPTQ DLPTFIQMGR
110 120 130 140 150
DKNFSTLHTV LCATGGGAYK FEKDFRTIGN LHLHKLDELD CLVKGLLYID
160 170 180 190 200
SVSFNGQAEC YYFANASEPE RCQKMPFNLD DPYPLLVVNI GSGVSILAVH
210 220 230 240 250
SKDNYKRVTG TSLGGGTFLG LCSLLTGCES FEEALEMASK GDSTQADKLV
260 270 280 290 300
RDIYGGDYER FGLPGWAVAS SFGNMIYKEK RESVSKEDLA RATLVTITNN
310 320 330 340 350
IGSIARMCAV NEKINRVVFV GNFLRVNTLS MKLLAYALDY WSKGQLKALF
360 370
LEHEGYFGAV GALLGLPNFS
Length:370
Mass (Da):41,117
Last modified:October 31, 2006 - v1
Checksum:iE8EEE55E678DB23A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123859 mRNA Translation: AAI23860.1
RefSeqiNP_001068931.1, NM_001075463.1
UniGeneiBt.26736

Genome annotation databases

EnsembliENSBTAT00000015780; ENSBTAP00000015780; ENSBTAG00000011895
GeneIDi510749
KEGGibta:510749

Similar proteinsi

Entry informationi

Entry nameiPANK3_BOVIN
AccessioniPrimary (citable) accession number: Q08DA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health