Reviewed,
UniProtKB/Swiss-Prot Q08DA3 (UBP16_BOVIN)
Last modified
September 1, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 16 EC=3.1.2.15 Alternative name(s): Ubiquitin thioesterase 16 Ubiquitin-specific-processing protease 16 Deubiquitinating enzyme 16 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 826 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B By similarity. |
| Catalytic activity | Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Nucleus By similarity. |
| Domain | The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin By similarity. |
| Post-translational modification | Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The phosphorylated form of the protein is also enzymatically active By similarity. |
| Sequence similarities | Belongs to the peptidase C19 family. USP16 subfamily. Contains 1 UBP-type zinc finger. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 826 | 826 | Ubiquitin carboxyl-terminal hydrolase 16 | PRO_0000367501 | |||||
Regions | |||||||||
| Zinc finger | 60 – 125 | 66 | UBP-type | ||||||
Sites | |||||||||
| Active site | 204 | 1 | By similarity | ||||||
| Active site | 752 | 1 | By similarity | ||||||
| Active site | 760 | 1 | By similarity | ||||||
| Metal binding | 24 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 26 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 48 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 51 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 74 | 1 | Zinc 3 By similarity | ||||||
| Metal binding | 77 | 1 | Zinc 3 By similarity | ||||||
| Metal binding | 82 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 88 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 90 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 94 | 1 | Zinc 3 By similarity | ||||||
| Metal binding | 103 | 1 | Zinc 3 By similarity | ||||||
| Metal binding | 116 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 119 | 1 | Zinc 1 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 414 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 551 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle. |
Cross-references
Sequence databases | |
|---|---|
| BC123861 mRNA. Translation: AAI23862.1. | |
| IPI | IPI00706867. |
| RefSeq | NP_001070335.1. |
| UniGene | Bt.51616 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | C19.021. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000026801; ENSBTAP00000026801; ENSBTAG00000020122; Bos taurus. [Genome view] |
| GeneID | 519992. |
| KEGG | bta:519992. |
Organism-specific databases | |
| CTD | 519992. |
Phylogenomic databases | |
| HOVERGEN | Q08DA3. |
Family and domain databases | |
| InterPro | IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR001607. Znf_UBP. [Graphical view] |
| Pfam | PF00443. UCH. 1 hit. PF02148. zf-UBP. 1 hit. [Graphical view] |
| PROSITE | PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50271. ZF_UBP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UBP16_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q08DA3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


