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Protein

Rab-like protein 6

Gene

RABL6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57GTPSequence analysis8
Nucleotide bindingi100 – 104GTPSequence analysis5
Nucleotide bindingi177 – 179GTPSequence analysis3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 6
Alternative name(s):
GTP-binding protein Parf
Rab-like protein 1
Short name:
RBEL1
Gene namesi
Name:RABL6
Synonyms:PARF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

  • Nucleus Curated
  • Cytoplasm By similarity

  • Note: Predominantly cytoplasmic.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742221 – 701Rab-like protein 6Add BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei416PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei573PhosphothreonineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08DA0.
PRIDEiQ08DA0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000039573.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001237.

Structurei

3D structure databases

ProteinModelPortaliQ08DA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 279Small GTPase-likeAdd BLAST241
Regioni629 – 667Interaction with CDKN2ABy similarityAdd BLAST39

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00390000016002.
HOGENOMiHOG000231561.
HOVERGENiHBG080325.
InParanoidiQ08DA0.
OMAiPHSKDIS.
OrthoDBiEOG091G05OK.
TreeFamiTF313974.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08477. Roc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08DA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSALKKLVG SEQAPGRDRN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG
60 70 80 90 100
DRNTGKTALW HRLQGKKFVE EYIPTQEIQV TSIHWSYKTT DDVVKVEVWD
110 120 130 140 150
VVDKGKCKKR GDGLKMENDP QEAESEMALD AEFLDVYKNC NGVVMMFDIT
160 170 180 190 200
KQWTFNYILR ELPKVPTHVP VCVLGNYRDM GEHRVILPDD VRDVLDHLDR
210 220 230 240 250
PPGSSYFRYA ESSMKNSFGL KYLHRFFNIP FLQLQRETLL RQLETNQLDI
260 270 280 290 300
DATLEELSVQ QETEDQNYDI FLEMMEARSR GHASPLTTSG QSPSSGSQSP
310 320 330 340 350
VVPPSTVSTG SSSPSTPQPV LQPPLQAPPA PPAPAEAPPL PAAPPRRSII
360 370 380 390 400
ARLFGSTPAT EAAPPPPEPT PAAEASQKVQ NVEDFVPEDS LDGSFLEDTV
410 420 430 440 450
PAKDEKRLGA RGPQDSDSDR ETQAGNPMVA GFQDDVDLED KPPSRPLPPT
460 470 480 490 500
GPVPSEDITL SSEEEAEEGA GHPKAAVLAP QKCPEPETRR SSTKALGPPR
510 520 530 540 550
DAAPRAAKPR PEGPSGKLEE GTDKPVSSES DAEGPIAAQM LSFVMDDPDF
560 570 580 590 600
ESDSDAQRRA GEFPVREDLS DLTDEDAGPV QPPAPPKPLA PSFRLKDDSD
610 620 630 640 650
LFGLGLEEPG REDSSEQDKE GRPPAKEKKK KKKKGREEED KAAKKRSKHK
660 670 680 690 700
KSRERADDKG RDERRRRPRG PQRTALDELE AFLGGGAPSG PLRGGGDYEA

L
Length:701
Mass (Da):77,097
Last modified:October 31, 2006 - v1
Checksum:iF719D2989CB1400A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123865 mRNA. Translation: AAI23866.1.
RefSeqiNP_001070285.1. NM_001076817.1.
UniGeneiBt.32412.

Genome annotation databases

EnsembliENSBTAT00000001237; ENSBTAP00000001237; ENSBTAG00000039573.
GeneIDi508218.
KEGGibta:508218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123865 mRNA. Translation: AAI23866.1.
RefSeqiNP_001070285.1. NM_001076817.1.
UniGeneiBt.32412.

3D structure databases

ProteinModelPortaliQ08DA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001237.

Proteomic databases

PaxDbiQ08DA0.
PRIDEiQ08DA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001237; ENSBTAP00000001237; ENSBTAG00000039573.
GeneIDi508218.
KEGGibta:508218.

Organism-specific databases

CTDi55684.

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00390000016002.
HOGENOMiHOG000231561.
HOVERGENiHBG080325.
InParanoidiQ08DA0.
OMAiPHSKDIS.
OrthoDBiEOG091G05OK.
TreeFamiTF313974.

Gene expression databases

BgeeiENSBTAG00000039573.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08477. Roc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRABL6_BOVIN
AccessioniPrimary (citable) accession number: Q08DA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.