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Protein

Keratin, type II cytoskeletal 75

Gene

KRT75

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei396Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 75
Alternative name(s):
Cytokeratin-75
Short name:
CK-75
Keratin-6 hair follicle
Keratin-75
Short name:
K75
Type II keratin-K6hf
Type-II keratin Kb18
Gene namesi
Name:KRT75
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148861 – 543Keratin, type II cytoskeletal 75Add BLAST543

Proteomic databases

PaxDbiQ08D91.
PeptideAtlasiQ08D91.
PRIDEiQ08D91.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. May associate with KRT17.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038262.

Structurei

3D structure databases

ProteinModelPortaliQ08D91.
SMRiQ08D91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 458IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 144HeadAdd BLAST144
Regioni145 – 180Coil 1AAdd BLAST36
Regioni181 – 199Linker 1Add BLAST19
Regioni200 – 292Coil 1BAdd BLAST93
Regioni293 – 315Linker 12Add BLAST23
Regioni316 – 454Coil 2Add BLAST139
Regioni455 – 543TailAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 116Gly-richAdd BLAST78

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ08D91.
KOiK07605.
OMAiYNLGGAK.
OrthoDBiEOG091G09KR.
TreeFamiTF317854.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF_ROD_1. 1 hit.
PS51842. IF_ROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08D91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSTITFQ TSSRRGFSTA SATTPATSRS RFSSASVTHS PAGSGGLGRI
60 70 80 90 100
SGFGSRSLYN LGGTKRVSIS GCGSNFRSGF GGRASSGFGV SGGFGYGGGI
110 120 130 140 150
GGGHGGCGFS VCPPGGIQEV TVNQSLLTPL NLQIDPNIQR VRKEEREQIK
160 170 180 190 200
TLNNKFASFI DKVRFLEQQN KVLETKWSLL QEQGTRTVRQ SLEPFFEAYI
210 220 230 240 250
TDLRRQLDSI TTERGRLDAE LRTMQDVVED FKVRYEDEIN KRTAAENEFV
260 270 280 290 300
ALKKDVDAAY LNKVDLEAKA NSLTDEINFL QMLFEAELCQ MQTRVSDTSV
310 320 330 340 350
VLSMDNNRSL DLDSIIAEVK AQYEEIANRS RAEAESWYQT KYEELQVTAG
360 370 380 390 400
QHGDDLRNTK QEISETNRMI QRLRAEIDNV KKQCASLQTA IADAEQRGEL
410 420 430 440 450
ALKDARAKLV DLEEALQKSK QDMARLLREY QELMNIKLAL DVEIATYRKL
460 470 480 490 500
LEGEECRLSG EGVSPVNISV VTSTVSSGYG GGSSIGSGSL GLSGGSGCSF
510 520 530 540
MTSGGHSLGG SSFSNSSSRG LGGSGSSFKF VSTTSSSRKS YKH
Length:543
Mass (Da):59,036
Last modified:October 31, 2006 - v1
Checksum:i8DA005DCCA94BA0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123881 mRNA. Translation: AAI23882.1.
RefSeqiNP_001070385.1. NM_001076917.1.
UniGeneiBt.33619.

Genome annotation databases

EnsembliENSBTAT00000038449; ENSBTAP00000038262; ENSBTAG00000016121.
GeneIDi539683.
KEGGibta:539683.

Similar proteinsi

Entry informationi

Entry nameiK2C75_BOVIN
AccessioniPrimary (citable) accession number: Q08D91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families