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Protein

Keratin, type II cytoskeletal 75

Gene

KRT75

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei396 – 3961Stutter

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 75
Alternative name(s):
Cytokeratin-75
Short name:
CK-75
Keratin-6 hair follicle
Keratin-75
Short name:
K75
Type II keratin-K6hf
Type-II keratin Kb18
Gene namesi
Name:KRT75
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Keratin, type II cytoskeletal 75PRO_0000314886Add
BLAST

Proteomic databases

PaxDbiQ08D91.
PeptideAtlasiQ08D91.
PRIDEiQ08D91.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. May associate with KRT17.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038262.

Structurei

3D structure databases

ProteinModelPortaliQ08D91.
SMRiQ08D91. Positions 144-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 144144HeadAdd
BLAST
Regioni145 – 454310RodAdd
BLAST
Regioni145 – 18036Coil 1AAdd
BLAST
Regioni181 – 19919Linker 1Add
BLAST
Regioni200 – 29293Coil 1BAdd
BLAST
Regioni293 – 31523Linker 12Add
BLAST
Regioni316 – 454139Coil 2Add
BLAST
Regioni455 – 54389TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 11678Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ08D91.
KOiK07605.
OMAiRQSTITF.
OrthoDBiEOG091G09KR.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08D91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSTITFQ TSSRRGFSTA SATTPATSRS RFSSASVTHS PAGSGGLGRI
60 70 80 90 100
SGFGSRSLYN LGGTKRVSIS GCGSNFRSGF GGRASSGFGV SGGFGYGGGI
110 120 130 140 150
GGGHGGCGFS VCPPGGIQEV TVNQSLLTPL NLQIDPNIQR VRKEEREQIK
160 170 180 190 200
TLNNKFASFI DKVRFLEQQN KVLETKWSLL QEQGTRTVRQ SLEPFFEAYI
210 220 230 240 250
TDLRRQLDSI TTERGRLDAE LRTMQDVVED FKVRYEDEIN KRTAAENEFV
260 270 280 290 300
ALKKDVDAAY LNKVDLEAKA NSLTDEINFL QMLFEAELCQ MQTRVSDTSV
310 320 330 340 350
VLSMDNNRSL DLDSIIAEVK AQYEEIANRS RAEAESWYQT KYEELQVTAG
360 370 380 390 400
QHGDDLRNTK QEISETNRMI QRLRAEIDNV KKQCASLQTA IADAEQRGEL
410 420 430 440 450
ALKDARAKLV DLEEALQKSK QDMARLLREY QELMNIKLAL DVEIATYRKL
460 470 480 490 500
LEGEECRLSG EGVSPVNISV VTSTVSSGYG GGSSIGSGSL GLSGGSGCSF
510 520 530 540
MTSGGHSLGG SSFSNSSSRG LGGSGSSFKF VSTTSSSRKS YKH
Length:543
Mass (Da):59,036
Last modified:October 31, 2006 - v1
Checksum:i8DA005DCCA94BA0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123881 mRNA. Translation: AAI23882.1.
RefSeqiNP_001070385.1. NM_001076917.1.
UniGeneiBt.33619.

Genome annotation databases

EnsembliENSBTAT00000038449; ENSBTAP00000038262; ENSBTAG00000016121.
GeneIDi539683.
KEGGibta:539683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123881 mRNA. Translation: AAI23882.1.
RefSeqiNP_001070385.1. NM_001076917.1.
UniGeneiBt.33619.

3D structure databases

ProteinModelPortaliQ08D91.
SMRiQ08D91. Positions 144-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038262.

Proteomic databases

PaxDbiQ08D91.
PeptideAtlasiQ08D91.
PRIDEiQ08D91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000038449; ENSBTAP00000038262; ENSBTAG00000016121.
GeneIDi539683.
KEGGibta:539683.

Organism-specific databases

CTDi9119.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ08D91.
KOiK07605.
OMAiRQSTITF.
OrthoDBiEOG091G09KR.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C75_BOVIN
AccessioniPrimary (citable) accession number: Q08D91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.