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Protein

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Gene

alg10

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Protein family/group databases

CAZyiGT59 Glycosyltransferase Family 59

Names & Taxonomyi

Protein namesi
Recommended name:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseUniRule annotation (EC:2.4.1.256UniRule annotation)
Gene namesi
Name:alg10Imported
Synonyms:LOC548946Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-976267 alg10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalUniRule annotationAdd BLAST19
Transmembranei65 – 84HelicalUniRule annotationAdd BLAST20
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei128 – 149HelicalUniRule annotationAdd BLAST22
Transmembranei155 – 182HelicalUniRule annotationAdd BLAST28
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei280 – 300HelicalUniRule annotationAdd BLAST21
Transmembranei320 – 343HelicalUniRule annotationAdd BLAST24
Transmembranei364 – 381HelicalUniRule annotationAdd BLAST18
Transmembranei387 – 404HelicalUniRule annotationAdd BLAST18
Transmembranei433 – 452HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG10 glucosyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2642 Eukaryota
ENOG410YGXE LUCA
HOGENOMiHOG000240902
HOVERGENiHBG053222
KOiK03850

Family and domain databases

InterProiView protein in InterPro
IPR016900 Alg10
PANTHERiPTHR12989 PTHR12989, 1 hit
PfamiView protein in Pfam
PF04922 DIE2_ALG10, 1 hit
PIRSFiPIRSF028810 Alpha1_2_glucosyltferase_Alg10, 1 hit

Sequencei

Sequence statusi: Complete.

Q08D71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLEGYYFS ALFSGCFLLS SILFSKITRQ QRDPYMDESF HIPQAQLYCQ
60 70 80 90 100
GHFNQWDPMI TTLPGLYLAS VGMVKPAAWL FGWSDSVACS SGMLRFINLL
110 120 130 140 150
FSLGNLYMIY LILSKINCKN KVSSFKKILS TLTLYAFPTL YFFTFLYYTD
160 170 180 190 200
TGSTFFVLFA YLMCLYGNHK SASLLGLCAF FFRQTNIIWI IFCAGNVISE
210 220 230 240 250
KLTEAWKTHL KKRDENPSAK GSVSEAVKAL VFLFQYCLSV RNIIMLVQLT
260 270 280 290 300
WPYITLVLGF FVFLSFNGGI VVGDKTSHEA CLNFPQLFYF LGFTLIFSFS
310 320 330 340 350
HLFSPQKLKE FIKSVWKQPL IYMALAGISV ILIWKFTYVH KYLLADNRHY
360 370 380 390 400
TFYVWRKIFQ RHELVKHLLV PGYLFAAWSF ADSLKGKSIF WLLMFYSCLL
410 420 430 440 450
AAMVPQKLLE FRYFIVPYII FRLNIPIPSV PKILLELALY VTINVFSFYL
460
FLHKTFQWPD NEQVQRFMW
Length:469
Mass (Da):54,789
Last modified:October 31, 2006 - v1
Checksum:i6984B02180C2A15F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123914 mRNA Translation: AAI23915.1
RefSeqiNP_001016192.2, NM_001016192.3
UniGeneiStr.26858

Genome annotation databases

GeneIDi548946
KEGGixtr:548946

Similar proteinsi

Entry informationi

Entry nameiQ08D71_XENTR
AccessioniPrimary (citable) accession number: Q08D71
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health