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Protein

E3 ubiquitin-protein ligase ZNRF3

Gene

znrf3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 30742RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-XTR-4641263. Regulation of FZD by ubiquitination.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZNRF3 (EC:6.3.2.-)
Alternative name(s):
Zinc/RING finger protein 3
Gene namesi
Name:znrf3
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5937936. znrf3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 192164ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Topological domaini214 – 853640CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 853825E3 ubiquitin-protein ligase ZNRF3PRO_0000418385Add
BLAST

Proteomic databases

PaxDbiQ08D68.

Expressioni

Gene expression databases

BgeeiQ08D68.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043145.

Structurei

Secondary structure

1
853
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 4111Combined sources
Beta strandi43 – 453Combined sources
Beta strandi47 – 5812Combined sources
Beta strandi60 – 623Combined sources
Beta strandi67 – 737Combined sources
Helixi76 – 783Combined sources
Beta strandi81 – 833Combined sources
Beta strandi91 – 988Combined sources
Helixi102 – 1043Combined sources
Beta strandi105 – 1073Combined sources
Helixi112 – 12110Combined sources
Beta strandi124 – 1307Combined sources
Helixi136 – 1427Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi153 – 1564Combined sources
Helixi158 – 17013Combined sources
Beta strandi175 – 1795Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C8TX-ray2.40A/B24-191[»]
4C8UX-ray3.01A/B24-191[»]
4C9RX-ray2.10A/C24-191[»]
4C9UX-ray3.00A/C24-191[»]
ProteinModelPortaliQ08D68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi502 – 662161Ser-richAdd
BLAST
Compositional biasi758 – 77619Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the ZNRF3 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri266 – 30742RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000155811.
HOVERGENiHBG082538.
InParanoidiQ08D68.
KOiK16273.
OrthoDBiEOG7P5T06.
TreeFamiTF317074.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08D68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEPRIRGGL PLVWLWVLLA VAPGESLAKE TAFVEVVLFE SSPNGDYKTH
60 70 80 90 100
TTELQGRFSR AGATISAEGE IVQMHPLGLC NNNDEEDLYE YGWVGVVKLE
110 120 130 140 150
QPEMDPKPCL TVLGKAKRAV QRGATAVIFD VSDNPDAVEQ LNQGLEDPLK
160 170 180 190 200
RPVVYMKGMD AIKLMNIVNK QKGARARIQH RPPRQPTEYF DMGIFLAFFV
210 220 230 240 250
VVSLVCLILL IKIKLKQRRS QNSMNRMAVQ ALEKMETRKF KAKGKVPREG
260 270 280 290 300
SCGGLDTLSS SSTSDCAICL EKYIDGEELR VIPCTHRFHK RCVDPWLLQN
310 320 330 340 350
HTCPHCRHNI IEQKKGGHGP VCVENSSNRG RQQQQQRVIL PVHYPGRVQR
360 370 380 390 400
TGPIAAYPTR TSMGPHGNPI TVLTVERPLE PDLYPARTPT FLAGYRPVSL
410 420 430 440 450
DHASSGHHCD LEHPPYPAPP AGHGFRRAKY SGRGFNNGTC YSQYETMYQH
460 470 480 490 500
YYFQGLSYPH QQEVGGSQAP RVVENGHNHS FHSGNNMLYQ PAPTLMHMAP
510 520 530 540 550
PSSVGSCYLH SQHQHRSVCS GYLADVPCSD SSSSSSASSA QGHASSSDSM
560 570 580 590 600
LDCTEASNQG VYGSCSTFRS SLSSDFDPYV YRSRSPARTG GGDAPGCGGE
610 620 630 640 650
GGTGSGRGRV ECRSHQTFPN SPSRDRLSSC SMEMNYSSNS SLERRGAVIS
660 670 680 690 700
SGTVPDASVS ISQGGGKDRR GPEKGCTCCF QRQAGDPSSD CTNLYLGPDP
710 720 730 740 750
HQTSGPSSSG GLYSVTSSIL HRTDPGTVLG HPSRPCCLYE ENHGSCYNED
760 770 780 790 800
YAVSIQYALA EAAAAAAAAA VAGCEAGQPI PIIPEDPGYD GGLECVGHVS
810 820 830 840 850
WEMEGEEEEE EVLYCQEGPC CALAEETRAL CRSTGKEGAG STTGQDCHPT

DRD
Length:853
Mass (Da):92,605
Last modified:October 31, 2006 - v1
Checksum:i33A70DAAC3E6453F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01003629 Genomic DNA. No translation available.
AAMC01003630 Genomic DNA. No translation available.
AAMC01003631 Genomic DNA. No translation available.
AAMC01003632 Genomic DNA. No translation available.
AAMC01003633 Genomic DNA. No translation available.
AAMC01003634 Genomic DNA. No translation available.
AAMC01003635 Genomic DNA. No translation available.
BC123917 mRNA. Translation: AAI23918.1.
RefSeqiNP_001072864.1. NM_001079396.1.
UniGeneiStr.31023.

Genome annotation databases

EnsembliENSXETT00000043145; ENSXETP00000043145; ENSXETG00000019942.
GeneIDi780325.
KEGGixtr:780325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01003629 Genomic DNA. No translation available.
AAMC01003630 Genomic DNA. No translation available.
AAMC01003631 Genomic DNA. No translation available.
AAMC01003632 Genomic DNA. No translation available.
AAMC01003633 Genomic DNA. No translation available.
AAMC01003634 Genomic DNA. No translation available.
AAMC01003635 Genomic DNA. No translation available.
BC123917 mRNA. Translation: AAI23918.1.
RefSeqiNP_001072864.1. NM_001079396.1.
UniGeneiStr.31023.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C8TX-ray2.40A/B24-191[»]
4C8UX-ray3.01A/B24-191[»]
4C9RX-ray2.10A/C24-191[»]
4C9UX-ray3.00A/C24-191[»]
ProteinModelPortaliQ08D68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043145.

Proteomic databases

PaxDbiQ08D68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000043145; ENSXETP00000043145; ENSXETG00000019942.
GeneIDi780325.
KEGGixtr:780325.

Organism-specific databases

CTDi84133.
XenbaseiXB-GENE-5937936. znrf3.

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000155811.
HOVERGENiHBG082538.
InParanoidiQ08D68.
KOiK16273.
OrthoDBiEOG7P5T06.
TreeFamiTF317074.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-XTR-4641263. Regulation of FZD by ubiquitination.

Gene expression databases

BgeeiQ08D68.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZNRF3_XENTR
AccessioniPrimary (citable) accession number: Q08D68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: October 31, 2006
Last modified: December 9, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.