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Protein

E3 ubiquitin-protein ligase ZNRF3

Gene

znrf3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri266 – 307RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-XTR-4641263. Regulation of FZD by ubiquitination.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZNRF3 (EC:6.3.2.-)
Alternative name(s):
Zinc/RING finger protein 3
Gene namesi
Name:znrf3
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5937936. znrf3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 192ExtracellularSequence analysisAdd BLAST164
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 853CytoplasmicSequence analysisAdd BLAST640

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000041838529 – 853E3 ubiquitin-protein ligase ZNRF3Add BLAST825

Proteomic databases

PaxDbiQ08D68.

Expressioni

Gene expression databases

BgeeiENSXETG00000019942.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043145.

Structurei

Secondary structure

1853
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 41Combined sources11
Beta strandi43 – 45Combined sources3
Beta strandi47 – 58Combined sources12
Beta strandi60 – 62Combined sources3
Beta strandi67 – 73Combined sources7
Helixi76 – 78Combined sources3
Beta strandi81 – 83Combined sources3
Beta strandi91 – 98Combined sources8
Helixi102 – 104Combined sources3
Beta strandi105 – 107Combined sources3
Helixi112 – 121Combined sources10
Beta strandi124 – 130Combined sources7
Helixi136 – 142Combined sources7
Beta strandi149 – 151Combined sources3
Beta strandi153 – 156Combined sources4
Helixi158 – 170Combined sources13
Beta strandi175 – 179Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C8TX-ray2.40A/B24-191[»]
4C8UX-ray3.01A/B24-191[»]
4C9RX-ray2.10A/C24-191[»]
4C9UX-ray3.00A/C24-191[»]
ProteinModelPortaliQ08D68.
SMRiQ08D68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi502 – 662Ser-richAdd BLAST161
Compositional biasi758 – 776Ala-richAdd BLAST19

Sequence similaritiesi

Belongs to the ZNRF3 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri266 – 307RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000155811.
HOVERGENiHBG082538.
InParanoidiQ08D68.
KOiK16273.
OrthoDBiEOG091G01HM.
TreeFamiTF317074.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08D68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEPRIRGGL PLVWLWVLLA VAPGESLAKE TAFVEVVLFE SSPNGDYKTH
60 70 80 90 100
TTELQGRFSR AGATISAEGE IVQMHPLGLC NNNDEEDLYE YGWVGVVKLE
110 120 130 140 150
QPEMDPKPCL TVLGKAKRAV QRGATAVIFD VSDNPDAVEQ LNQGLEDPLK
160 170 180 190 200
RPVVYMKGMD AIKLMNIVNK QKGARARIQH RPPRQPTEYF DMGIFLAFFV
210 220 230 240 250
VVSLVCLILL IKIKLKQRRS QNSMNRMAVQ ALEKMETRKF KAKGKVPREG
260 270 280 290 300
SCGGLDTLSS SSTSDCAICL EKYIDGEELR VIPCTHRFHK RCVDPWLLQN
310 320 330 340 350
HTCPHCRHNI IEQKKGGHGP VCVENSSNRG RQQQQQRVIL PVHYPGRVQR
360 370 380 390 400
TGPIAAYPTR TSMGPHGNPI TVLTVERPLE PDLYPARTPT FLAGYRPVSL
410 420 430 440 450
DHASSGHHCD LEHPPYPAPP AGHGFRRAKY SGRGFNNGTC YSQYETMYQH
460 470 480 490 500
YYFQGLSYPH QQEVGGSQAP RVVENGHNHS FHSGNNMLYQ PAPTLMHMAP
510 520 530 540 550
PSSVGSCYLH SQHQHRSVCS GYLADVPCSD SSSSSSASSA QGHASSSDSM
560 570 580 590 600
LDCTEASNQG VYGSCSTFRS SLSSDFDPYV YRSRSPARTG GGDAPGCGGE
610 620 630 640 650
GGTGSGRGRV ECRSHQTFPN SPSRDRLSSC SMEMNYSSNS SLERRGAVIS
660 670 680 690 700
SGTVPDASVS ISQGGGKDRR GPEKGCTCCF QRQAGDPSSD CTNLYLGPDP
710 720 730 740 750
HQTSGPSSSG GLYSVTSSIL HRTDPGTVLG HPSRPCCLYE ENHGSCYNED
760 770 780 790 800
YAVSIQYALA EAAAAAAAAA VAGCEAGQPI PIIPEDPGYD GGLECVGHVS
810 820 830 840 850
WEMEGEEEEE EVLYCQEGPC CALAEETRAL CRSTGKEGAG STTGQDCHPT

DRD
Length:853
Mass (Da):92,605
Last modified:October 31, 2006 - v1
Checksum:i33A70DAAC3E6453F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01003629 Genomic DNA. No translation available.
AAMC01003630 Genomic DNA. No translation available.
AAMC01003631 Genomic DNA. No translation available.
AAMC01003632 Genomic DNA. No translation available.
AAMC01003633 Genomic DNA. No translation available.
AAMC01003634 Genomic DNA. No translation available.
AAMC01003635 Genomic DNA. No translation available.
BC123917 mRNA. Translation: AAI23918.1.
RefSeqiNP_001072864.1. NM_001079396.1.
UniGeneiStr.31023.

Genome annotation databases

EnsembliENSXETT00000043145; ENSXETP00000043145; ENSXETG00000019942.
GeneIDi780325.
KEGGixtr:780325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01003629 Genomic DNA. No translation available.
AAMC01003630 Genomic DNA. No translation available.
AAMC01003631 Genomic DNA. No translation available.
AAMC01003632 Genomic DNA. No translation available.
AAMC01003633 Genomic DNA. No translation available.
AAMC01003634 Genomic DNA. No translation available.
AAMC01003635 Genomic DNA. No translation available.
BC123917 mRNA. Translation: AAI23918.1.
RefSeqiNP_001072864.1. NM_001079396.1.
UniGeneiStr.31023.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C8TX-ray2.40A/B24-191[»]
4C8UX-ray3.01A/B24-191[»]
4C9RX-ray2.10A/C24-191[»]
4C9UX-ray3.00A/C24-191[»]
ProteinModelPortaliQ08D68.
SMRiQ08D68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043145.

Proteomic databases

PaxDbiQ08D68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000043145; ENSXETP00000043145; ENSXETG00000019942.
GeneIDi780325.
KEGGixtr:780325.

Organism-specific databases

CTDi84133.
XenbaseiXB-GENE-5937936. znrf3.

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000155811.
HOVERGENiHBG082538.
InParanoidiQ08D68.
KOiK16273.
OrthoDBiEOG091G01HM.
TreeFamiTF317074.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-XTR-4641263. Regulation of FZD by ubiquitination.

Gene expression databases

BgeeiENSXETG00000019942.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNRF3_XENTR
AccessioniPrimary (citable) accession number: Q08D68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.