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Protein

ATP-binding cassette sub-family B member 6, mitochondrial

Gene

abcb6

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei590ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi614 – 625ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 6, mitochondrial
Gene namesi
Name:abcb6
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1001119. abcb6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei73 – 93HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei99 – 119HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei137 – 157HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei174 – 194HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei255 – 275HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei292 – 312HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei374 – 394HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei402 – 422HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei493 – 513HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei521 – 541HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686801 – 849ATP-binding cassette sub-family B member 6, mitochondrialAdd BLAST849

Proteomic databases

PaxDbiQ08D64.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000030397.

Structurei

3D structure databases

ProteinModelPortaliQ08D64.
SMRiQ08D64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini256 – 547ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST292
Domaini581 – 815ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
HOVERGENiHBG080810.
InParanoidiQ08D64.
KOiK05661.
OrthoDBiEOG091G02G4.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR032410. MTABC_N.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF16185. MTABC_N. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08D64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLGSYCEH NGSISQAWLD SGLSPCFYFT LVPSVLLSFS FLLGALQSAL
60 70 80 90 100
YARHSTTMEP KYIPRSRLYR LQIVLSVVLI LQSVIGLIWQ AAGTDVVYGY
110 120 130 140 150
MIVHGCLSVV AWGFSLWLLH LERTRALVRE KSRGHGVVLL LFWALAFAAE
160 170 180 190 200
NLAFISWQSP NWWWLSRDTV PQKVQFGLWI TRYVCTLFLF VLGIRAPGRP
210 220 230 240 250
RKPYIVLINE DERDVETSQP LLRDPNQSTW QGFKKKLLLV MQYIWPRRNI
260 270 280 290 300
PLQLLVALCM GLMGLERAIN VFVPIYAKKI VDGLTEDSTW NILAVTVCIY
310 320 330 340 350
VLLKFLQGGG AGTTGFLSNL RTFMWIRVQQ FTNREVQIRL FAHLHSLSLR
360 370 380 390 400
WHLGRKTGEV LRSVDRGTSS INSLLSYIVF SILPTIADIV IGIVYFTSSF
410 420 430 440 450
NAWFGLIIFV CMTLYLTLTI IITEWRTKYR REMNTRDNEA KSRAVDSLLN
460 470 480 490 500
FETVKYYNAE GYEVGRFNDS IMKYQVSEWK VNASLAMLNQ TQNLIIGLGL
510 520 530 540 550
LAGSLLCAYF VTENKFKVGD YVLFGTYIIQ LYTPLNWFGT YYRMIQSSFI
560 570 580 590 600
DMENMFELFN EDQEVKDAVN APALMFRSGK IEFENVHFSY LDGKEILRDI
610 620 630 640 650
SFTVMPGQSI ALVGPSGSGK STIIRLLFRF YDVKGGTIKV DGQDISTVRQ
660 670 680 690 700
ESLRSHIGVV PQDTVLFNDT IRNNIRYGRV SATDDEVEEA AAAADIHERI
710 720 730 740 750
LSFRDGYDTQ TGERGLKLSG GEKQRVAIAR TILKAPQIIL LDEATSALDT
760 770 780 790 800
ETERNIQASL AKVCANRTTI VVAHRLSTVI NSDQILVLKE GQIVERGRHE
810 820 830 840
ELLLKGGVYA GMWQKQQSGS ESSSDSDSER KDRTSEKLQP PKATPRRGH
Length:849
Mass (Da):96,270
Last modified:October 31, 2006 - v1
Checksum:i2FECDB9D26C490A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123925 mRNA. Translation: AAI23926.1.
RefSeqiNP_001072643.1. NM_001079175.1.
UniGeneiStr.43751.

Genome annotation databases

GeneIDi780100.
KEGGixtr:780100.

Similar proteinsi

Entry informationi

Entry nameiABCB6_XENTR
AccessioniPrimary (citable) accession number: Q08D64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families