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Q08D57

- SET1B_XENTR

UniProt

Q08D57 - SET1B_XENTR

Protein

Histone-lysine N-methyltransferase SETD1B

Gene

setd1b

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. nucleotide binding Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 1B
    Gene namesi
    Name:setd1b
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5842344. setd1b.

    Subcellular locationi

    Nucleus speckle By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19561956Histone-lysine N-methyltransferase SETD1BPRO_0000316998Add
    BLAST

    Proteomic databases

    PaxDbiQ08D57.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000008143.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08D57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini111 – 19989RRMPROSITE-ProRule annotationAdd
    BLAST
    Domaini1817 – 1934118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1940 – 195617Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi657 – 72266Pro-richAdd
    BLAST
    Compositional biasi987 – 1223237Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000168216.
    HOVERGENiHBG055596.
    KOiK11422.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08D57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFKEAKPGE RGKNPEDHGR KQTASWINGM EAGNQPSTSG EKKSHHWRSY     50
    KLIIDPALRK GQHKLYRYDG LSFSMPNSGV PPVDSVRDPR IGRIWTKTKE 100
    LDLPVPKLKI DEFYVGPVPP KQVTFAKLND NIRENFLGDM CKKYGEVEEV 150
    EILYNPKNKK HLGIAKVIFA SVKGARDAVK HLHNTSVMGN IIHVELDTKG 200
    ETRMRFYDLL VNGFYTPQTL PVGSDLDASP TVNETPQVVE SVKRTKETAI 250
    GPSVTPNSST PFSHDTAYSS SRQGTPNSYS QFTPQSQGTP HTPRLGTPFS 300
    QDSSYSSRQT TPAFHYGQDS GFKPRRHENK FTDAYNRRPG HHYVHSSGSY 350
    RGTEHTFNVT RPQPEPVQVP RTPPLSHSSG NYKSAFSPYQ GNTVFPQTDE 400
    SQYPQTSRDM EYRRTGPQTS DSYSDAGCNS ASLELKPVKE KPEEPPPPEP 450
    DSTTEQKASF SQTPERCETP GTPTLEAELQ HNSLDTRIAM LLKEQRTQLH 500
    LIAGDQNSDN EIRMEGSPIS SSSSQLSPIP PYSSGSRYQD VTPSSRPSST 550
    GLEDISPTPL PDSDDDDEPI PGTASLCQNS RSASPIDQIN QSGRKTESLD 600
    KKELVAGDET PTSEKMDEGH PSSGEDMEIS DDEVTPSPIT SAECAITSSS 650
    VISSVIPIPP PGFPPLPPPP PPQPGFPMPP PLPPPPPPTH PSVTVPPPPL 700
    PAPPGVPPHH ILHHPPPYHH FPVMQGEMMN VLGNHWGGMT MSFQMQTQML 750
    SRMMQGQGSY PYHHFMGGSM QFGNQHPYRP FAISAHLTRG QPWPPFPKFD 800
    PSVPPPGYEH KKEDPHKATV DGVLQVIVKE LKAIMKRDLN RKMVEVVAFR 850
    AFDEWWDKKE RLAKQSLTPV KSGESKEEDK QKTKEHITSS LLESWNKGEG 900
    LGFEGIGLGI GLRGAIRLPS FKVKRKEPPD AALAGDQKRI RPSHSVDDED 950
    EESERDRDIS STASDLSKKD ADAVNNRRRP ARPLDSEGEE EVESEGDDGE 1000
    TSDKEDSSSE KEDQDDGSVS ALSSKKQLYG DKEGDDEDDD TQSSGKEEDL 1050
    VSEEEDTTSV ASSRAEMDSS DESEESSEYE SSSDSDEKEE EDDEEEELVF 1100
    GDDQSEDQDL GQEYEVETDR EEDFFRENLS ECSSLPKAGD VELEDEMQKV 1150
    EEDVARQTTQ ETLHLRKKNL DVPLVESKEC KQDTLDKVEK LFAVPMQEEV 1200
    FKEHEKAPSP MNEEEEYIEL QLEPVPLVPE GAAPAAQEPV IIRPLTPTGA 1250
    FGETGPVLKL EEPKLQVNLT QFATEDEELY PRTPGRDTAA HSDTEVTFQP 1300
    GLKVAPSSLP FLPSHNKEEE CLLPPEKHAG HLTVTKMLSE EDLPRTPGRD 1350
    IVVKSSHLGK SQSTETVPAT PGSDAPLTGS SLTLTSPHIP GSPFSYLSQS 1400
    PGIINSGIPR TPGRDFNFTP TFPESNSIFP CHPSGKKPSV DEPDEKSFKE 1450
    PTSASLTMNS VPSPIPFASP PRGLPHMDIR LGADDLESSD TPAYLSDKLL 1500
    SEESECEFTK VHLTSTDESA PSPPLPPAEK RKGDRSKKPL SAHEFETEKN 1550
    YETSSAVAMS EGALGKQMFI GQPDAVSGIK DPAAVPLDFR NDSLSENTVH 1600
    EPIIQKVPLK ELENQWNEVL KEEEDITKHK KSRNSRHNNR YDEFSTVPSP 1650
    EFSPPRAMFK PRSEFEEMTI LYDIWNGGID DEDIKYMCIT YDRLLQQDNG 1700
    MDWLNDTLWV YHPSTSVYSP KKKKRDDGLR EHVTGCARSE GYYKIDKKDK 1750
    LKYLINNRSL TEELPIDTQG KSIPAQPQAS TRAGSERRSE QRRLLSSFTG 1800
    SCDSDLLKFN QLKFRKKKLR FCKSHIHDWG LFAMEPIIAD EMVIEYVGQN 1850
    IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF ARFINHSCNP 1900
    NCYAKVITVE SQKKIVIYSK QYINVNEEIT YDYKFPIEDV KIPCLCGAEN 1950
    CRGTLN 1956
    Length:1,956
    Mass (Da):218,069
    Last modified:October 31, 2006 - v1
    Checksum:i9AFF263E87E53DCD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123932 mRNA. Translation: AAI23933.1.
    RefSeqiNP_001072649.1. NM_001079181.1.
    UniGeneiStr.52478.

    Genome annotation databases

    GeneIDi780106.
    KEGGixtr:780106.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123932 mRNA. Translation: AAI23933.1 .
    RefSeqi NP_001072649.1. NM_001079181.1.
    UniGenei Str.52478.

    3D structure databases

    ProteinModelPortali Q08D57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000008143.

    Proteomic databases

    PaxDbi Q08D57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 780106.
    KEGGi xtr:780106.

    Organism-specific databases

    CTDi 23067.
    Xenbasei XB-GENE-5842344. setd1b.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000168216.
    HOVERGENi HBG055596.
    KOi K11422.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiSET1B_XENTR
    AccessioniPrimary (citable) accession number: Q08D57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3