Q08D57 (SET1B_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase SETD1B
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 1B

Gene names

Name:

setd1b

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	1956 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus speckle By similarity. Chromosome By similarity.
Sequence similarities	Contains 1 post-SET domain. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Activator Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1956	1956	Histone-lysine N-methyltransferase SETD1B		PRO_0000316998
Regions
	Domain	111 – 199	89	RRM
	Domain	1816 – 1938	123	SET
	Domain	1940 – 1956	17	Post-SET
	Compositional bias	657 – 722	66	Pro-rich
	Compositional bias	987 – 1223	237	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q08D57 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 9AFF263E87E53DCD	FASTA	1,956	218,069
	10 20 30 40 50 60 MSFKEAKPGE RGKNPEDHGR KQTASWINGM EAGNQPSTSG EKKSHHWRSY KLIIDPALRK 70 80 90 100 110 120 GQHKLYRYDG LSFSMPNSGV PPVDSVRDPR IGRIWTKTKE LDLPVPKLKI DEFYVGPVPP 130 140 150 160 170 180 KQVTFAKLND NIRENFLGDM CKKYGEVEEV EILYNPKNKK HLGIAKVIFA SVKGARDAVK 190 200 210 220 230 240 HLHNTSVMGN IIHVELDTKG ETRMRFYDLL VNGFYTPQTL PVGSDLDASP TVNETPQVVE 250 260 270 280 290 300 SVKRTKETAI GPSVTPNSST PFSHDTAYSS SRQGTPNSYS QFTPQSQGTP HTPRLGTPFS 310 320 330 340 350 360 QDSSYSSRQT TPAFHYGQDS GFKPRRHENK FTDAYNRRPG HHYVHSSGSY RGTEHTFNVT 370 380 390 400 410 420 RPQPEPVQVP RTPPLSHSSG NYKSAFSPYQ GNTVFPQTDE SQYPQTSRDM EYRRTGPQTS 430 440 450 460 470 480 DSYSDAGCNS ASLELKPVKE KPEEPPPPEP DSTTEQKASF SQTPERCETP GTPTLEAELQ 490 500 510 520 530 540 HNSLDTRIAM LLKEQRTQLH LIAGDQNSDN EIRMEGSPIS SSSSQLSPIP PYSSGSRYQD 550 560 570 580 590 600 VTPSSRPSST GLEDISPTPL PDSDDDDEPI PGTASLCQNS RSASPIDQIN QSGRKTESLD 610 620 630 640 650 660 KKELVAGDET PTSEKMDEGH PSSGEDMEIS DDEVTPSPIT SAECAITSSS VISSVIPIPP 670 680 690 700 710 720 PGFPPLPPPP PPQPGFPMPP PLPPPPPPTH PSVTVPPPPL PAPPGVPPHH ILHHPPPYHH 730 740 750 760 770 780 FPVMQGEMMN VLGNHWGGMT MSFQMQTQML SRMMQGQGSY PYHHFMGGSM QFGNQHPYRP 790 800 810 820 830 840 FAISAHLTRG QPWPPFPKFD PSVPPPGYEH KKEDPHKATV DGVLQVIVKE LKAIMKRDLN 850 860 870 880 890 900 RKMVEVVAFR AFDEWWDKKE RLAKQSLTPV KSGESKEEDK QKTKEHITSS LLESWNKGEG 910 920 930 940 950 960 LGFEGIGLGI GLRGAIRLPS FKVKRKEPPD AALAGDQKRI RPSHSVDDED EESERDRDIS 970 980 990 1000 1010 1020 STASDLSKKD ADAVNNRRRP ARPLDSEGEE EVESEGDDGE TSDKEDSSSE KEDQDDGSVS 1030 1040 1050 1060 1070 1080 ALSSKKQLYG DKEGDDEDDD TQSSGKEEDL VSEEEDTTSV ASSRAEMDSS DESEESSEYE 1090 1100 1110 1120 1130 1140 SSSDSDEKEE EDDEEEELVF GDDQSEDQDL GQEYEVETDR EEDFFRENLS ECSSLPKAGD 1150 1160 1170 1180 1190 1200 VELEDEMQKV EEDVARQTTQ ETLHLRKKNL DVPLVESKEC KQDTLDKVEK LFAVPMQEEV 1210 1220 1230 1240 1250 1260 FKEHEKAPSP MNEEEEYIEL QLEPVPLVPE GAAPAAQEPV IIRPLTPTGA FGETGPVLKL 1270 1280 1290 1300 1310 1320 EEPKLQVNLT QFATEDEELY PRTPGRDTAA HSDTEVTFQP GLKVAPSSLP FLPSHNKEEE 1330 1340 1350 1360 1370 1380 CLLPPEKHAG HLTVTKMLSE EDLPRTPGRD IVVKSSHLGK SQSTETVPAT PGSDAPLTGS 1390 1400 1410 1420 1430 1440 SLTLTSPHIP GSPFSYLSQS PGIINSGIPR TPGRDFNFTP TFPESNSIFP CHPSGKKPSV 1450 1460 1470 1480 1490 1500 DEPDEKSFKE PTSASLTMNS VPSPIPFASP PRGLPHMDIR LGADDLESSD TPAYLSDKLL 1510 1520 1530 1540 1550 1560 SEESECEFTK VHLTSTDESA PSPPLPPAEK RKGDRSKKPL SAHEFETEKN YETSSAVAMS 1570 1580 1590 1600 1610 1620 EGALGKQMFI GQPDAVSGIK DPAAVPLDFR NDSLSENTVH EPIIQKVPLK ELENQWNEVL 1630 1640 1650 1660 1670 1680 KEEEDITKHK KSRNSRHNNR YDEFSTVPSP EFSPPRAMFK PRSEFEEMTI LYDIWNGGID 1690 1700 1710 1720 1730 1740 DEDIKYMCIT YDRLLQQDNG MDWLNDTLWV YHPSTSVYSP KKKKRDDGLR EHVTGCARSE 1750 1760 1770 1780 1790 1800 GYYKIDKKDK LKYLINNRSL TEELPIDTQG KSIPAQPQAS TRAGSERRSE QRRLLSSFTG 1810 1820 1830 1840 1850 1860 SCDSDLLKFN QLKFRKKKLR FCKSHIHDWG LFAMEPIIAD EMVIEYVGQN IRQVIADMRE 1870 1880 1890 1900 1910 1920 KRYEDEGIGS SYMFRVDHDT IIDATKCGNF ARFINHSCNP NCYAKVITVE SQKKIVIYSK 1930 1940 1950 QYINVNEEIT YDYKFPIEDV KIPCLCGAEN CRGTLN

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC123932 mRNA. Translation: AAI23933.1.
RefSeq	NP_001072649.1. NM_001079181.1.
UniGene	Str.52478.
3D structure databases
ProteinModelPortal	Q08D57.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000008143.
Proteomic databases
PaxDb	Q08D57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	780106.
KEGG	xtr:780106.
Organism-specific databases
CTD	23067.
Xenbase	XB-GENE-5842344. setd1b.
Phylogenomic databases
eggNOG	COG2940.
HOGENOM	HOG000168216.
HOVERGEN	HBG055596.
KO	K11422.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR024657. COMPASS_Set1_N-SET. IPR015722. Histone-lysine_MeTfrase. IPR012677. Nucleotide-bd_a/b_plait. IPR003616. Post-SET_dom. IPR000504. RRM_dom. IPR001214. SET_dom. [Graphical view]
PANTHER	PTHR22884:SF10. PTHR22884:SF10. 1 hit.
Pfam	PF11764. N-SET. 1 hit. PF00076. RRM_1. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00360. RRM. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50102. RRM. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET1B_XENTR

Accession

Primary (citable) accession number: Q08D57

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 31, 2006
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program