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Q08D57

- SET1B_XENTR

UniProt

Q08D57 - SET1B_XENTR

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Protein
Histone-lysine N-methyltransferase SETD1B
Gene
setd1b
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. nucleotide binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 1B
Gene namesi
Name:setd1b
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5842344. setd1b.

Subcellular locationi

Nucleus speckle By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nuclear speck Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19561956Histone-lysine N-methyltransferase SETD1B
PRO_0000316998Add
BLAST

Proteomic databases

PaxDbiQ08D57.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000008143.

Structurei

3D structure databases

ProteinModelPortaliQ08D57.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 19989RRM
Add
BLAST
Domaini1817 – 1934118SET
Add
BLAST
Domaini1940 – 195617Post-SET
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi657 – 72266Pro-rich
Add
BLAST
Compositional biasi987 – 1223237Glu-rich
Add
BLAST

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000168216.
HOVERGENiHBG055596.
KOiK11422.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08D57-1 [UniParc]FASTAAdd to Basket

« Hide

MSFKEAKPGE RGKNPEDHGR KQTASWINGM EAGNQPSTSG EKKSHHWRSY     50
KLIIDPALRK GQHKLYRYDG LSFSMPNSGV PPVDSVRDPR IGRIWTKTKE 100
LDLPVPKLKI DEFYVGPVPP KQVTFAKLND NIRENFLGDM CKKYGEVEEV 150
EILYNPKNKK HLGIAKVIFA SVKGARDAVK HLHNTSVMGN IIHVELDTKG 200
ETRMRFYDLL VNGFYTPQTL PVGSDLDASP TVNETPQVVE SVKRTKETAI 250
GPSVTPNSST PFSHDTAYSS SRQGTPNSYS QFTPQSQGTP HTPRLGTPFS 300
QDSSYSSRQT TPAFHYGQDS GFKPRRHENK FTDAYNRRPG HHYVHSSGSY 350
RGTEHTFNVT RPQPEPVQVP RTPPLSHSSG NYKSAFSPYQ GNTVFPQTDE 400
SQYPQTSRDM EYRRTGPQTS DSYSDAGCNS ASLELKPVKE KPEEPPPPEP 450
DSTTEQKASF SQTPERCETP GTPTLEAELQ HNSLDTRIAM LLKEQRTQLH 500
LIAGDQNSDN EIRMEGSPIS SSSSQLSPIP PYSSGSRYQD VTPSSRPSST 550
GLEDISPTPL PDSDDDDEPI PGTASLCQNS RSASPIDQIN QSGRKTESLD 600
KKELVAGDET PTSEKMDEGH PSSGEDMEIS DDEVTPSPIT SAECAITSSS 650
VISSVIPIPP PGFPPLPPPP PPQPGFPMPP PLPPPPPPTH PSVTVPPPPL 700
PAPPGVPPHH ILHHPPPYHH FPVMQGEMMN VLGNHWGGMT MSFQMQTQML 750
SRMMQGQGSY PYHHFMGGSM QFGNQHPYRP FAISAHLTRG QPWPPFPKFD 800
PSVPPPGYEH KKEDPHKATV DGVLQVIVKE LKAIMKRDLN RKMVEVVAFR 850
AFDEWWDKKE RLAKQSLTPV KSGESKEEDK QKTKEHITSS LLESWNKGEG 900
LGFEGIGLGI GLRGAIRLPS FKVKRKEPPD AALAGDQKRI RPSHSVDDED 950
EESERDRDIS STASDLSKKD ADAVNNRRRP ARPLDSEGEE EVESEGDDGE 1000
TSDKEDSSSE KEDQDDGSVS ALSSKKQLYG DKEGDDEDDD TQSSGKEEDL 1050
VSEEEDTTSV ASSRAEMDSS DESEESSEYE SSSDSDEKEE EDDEEEELVF 1100
GDDQSEDQDL GQEYEVETDR EEDFFRENLS ECSSLPKAGD VELEDEMQKV 1150
EEDVARQTTQ ETLHLRKKNL DVPLVESKEC KQDTLDKVEK LFAVPMQEEV 1200
FKEHEKAPSP MNEEEEYIEL QLEPVPLVPE GAAPAAQEPV IIRPLTPTGA 1250
FGETGPVLKL EEPKLQVNLT QFATEDEELY PRTPGRDTAA HSDTEVTFQP 1300
GLKVAPSSLP FLPSHNKEEE CLLPPEKHAG HLTVTKMLSE EDLPRTPGRD 1350
IVVKSSHLGK SQSTETVPAT PGSDAPLTGS SLTLTSPHIP GSPFSYLSQS 1400
PGIINSGIPR TPGRDFNFTP TFPESNSIFP CHPSGKKPSV DEPDEKSFKE 1450
PTSASLTMNS VPSPIPFASP PRGLPHMDIR LGADDLESSD TPAYLSDKLL 1500
SEESECEFTK VHLTSTDESA PSPPLPPAEK RKGDRSKKPL SAHEFETEKN 1550
YETSSAVAMS EGALGKQMFI GQPDAVSGIK DPAAVPLDFR NDSLSENTVH 1600
EPIIQKVPLK ELENQWNEVL KEEEDITKHK KSRNSRHNNR YDEFSTVPSP 1650
EFSPPRAMFK PRSEFEEMTI LYDIWNGGID DEDIKYMCIT YDRLLQQDNG 1700
MDWLNDTLWV YHPSTSVYSP KKKKRDDGLR EHVTGCARSE GYYKIDKKDK 1750
LKYLINNRSL TEELPIDTQG KSIPAQPQAS TRAGSERRSE QRRLLSSFTG 1800
SCDSDLLKFN QLKFRKKKLR FCKSHIHDWG LFAMEPIIAD EMVIEYVGQN 1850
IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF ARFINHSCNP 1900
NCYAKVITVE SQKKIVIYSK QYINVNEEIT YDYKFPIEDV KIPCLCGAEN 1950
CRGTLN 1956
Length:1,956
Mass (Da):218,069
Last modified:October 31, 2006 - v1
Checksum:i9AFF263E87E53DCD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123932 mRNA. Translation: AAI23933.1.
RefSeqiNP_001072649.1. NM_001079181.1.
UniGeneiStr.52478.

Genome annotation databases

GeneIDi780106.
KEGGixtr:780106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123932 mRNA. Translation: AAI23933.1 .
RefSeqi NP_001072649.1. NM_001079181.1.
UniGenei Str.52478.

3D structure databases

ProteinModelPortali Q08D57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000008143.

Proteomic databases

PaxDbi Q08D57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 780106.
KEGGi xtr:780106.

Organism-specific databases

CTDi 23067.
Xenbasei XB-GENE-5842344. setd1b.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000168216.
HOVERGENi HBG055596.
KOi K11422.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSET1B_XENTR
AccessioniPrimary (citable) accession number: Q08D57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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