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Q08D57

- SET1B_XENTR

UniProt

Q08D57 - SET1B_XENTR

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Protein

Histone-lysine N-methyltransferase SETD1B

Gene

setd1b

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: InterPro
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 1B
Gene namesi
Name:setd1b
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5842344. setd1b.

Subcellular locationi

Nucleus speckle By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19561956Histone-lysine N-methyltransferase SETD1BPRO_0000316998Add
BLAST

Proteomic databases

PaxDbiQ08D57.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000008143.

Structurei

3D structure databases

ProteinModelPortaliQ08D57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 19989RRMPROSITE-ProRule annotationAdd
BLAST
Domaini1817 – 1934118SETPROSITE-ProRule annotationAdd
BLAST
Domaini1940 – 195617Post-SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi657 – 72266Pro-richAdd
BLAST
Compositional biasi987 – 1223237Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000168216.
HOVERGENiHBG055596.
InParanoidiQ08D57.
KOiK11422.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08D57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFKEAKPGE RGKNPEDHGR KQTASWINGM EAGNQPSTSG EKKSHHWRSY
60 70 80 90 100
KLIIDPALRK GQHKLYRYDG LSFSMPNSGV PPVDSVRDPR IGRIWTKTKE
110 120 130 140 150
LDLPVPKLKI DEFYVGPVPP KQVTFAKLND NIRENFLGDM CKKYGEVEEV
160 170 180 190 200
EILYNPKNKK HLGIAKVIFA SVKGARDAVK HLHNTSVMGN IIHVELDTKG
210 220 230 240 250
ETRMRFYDLL VNGFYTPQTL PVGSDLDASP TVNETPQVVE SVKRTKETAI
260 270 280 290 300
GPSVTPNSST PFSHDTAYSS SRQGTPNSYS QFTPQSQGTP HTPRLGTPFS
310 320 330 340 350
QDSSYSSRQT TPAFHYGQDS GFKPRRHENK FTDAYNRRPG HHYVHSSGSY
360 370 380 390 400
RGTEHTFNVT RPQPEPVQVP RTPPLSHSSG NYKSAFSPYQ GNTVFPQTDE
410 420 430 440 450
SQYPQTSRDM EYRRTGPQTS DSYSDAGCNS ASLELKPVKE KPEEPPPPEP
460 470 480 490 500
DSTTEQKASF SQTPERCETP GTPTLEAELQ HNSLDTRIAM LLKEQRTQLH
510 520 530 540 550
LIAGDQNSDN EIRMEGSPIS SSSSQLSPIP PYSSGSRYQD VTPSSRPSST
560 570 580 590 600
GLEDISPTPL PDSDDDDEPI PGTASLCQNS RSASPIDQIN QSGRKTESLD
610 620 630 640 650
KKELVAGDET PTSEKMDEGH PSSGEDMEIS DDEVTPSPIT SAECAITSSS
660 670 680 690 700
VISSVIPIPP PGFPPLPPPP PPQPGFPMPP PLPPPPPPTH PSVTVPPPPL
710 720 730 740 750
PAPPGVPPHH ILHHPPPYHH FPVMQGEMMN VLGNHWGGMT MSFQMQTQML
760 770 780 790 800
SRMMQGQGSY PYHHFMGGSM QFGNQHPYRP FAISAHLTRG QPWPPFPKFD
810 820 830 840 850
PSVPPPGYEH KKEDPHKATV DGVLQVIVKE LKAIMKRDLN RKMVEVVAFR
860 870 880 890 900
AFDEWWDKKE RLAKQSLTPV KSGESKEEDK QKTKEHITSS LLESWNKGEG
910 920 930 940 950
LGFEGIGLGI GLRGAIRLPS FKVKRKEPPD AALAGDQKRI RPSHSVDDED
960 970 980 990 1000
EESERDRDIS STASDLSKKD ADAVNNRRRP ARPLDSEGEE EVESEGDDGE
1010 1020 1030 1040 1050
TSDKEDSSSE KEDQDDGSVS ALSSKKQLYG DKEGDDEDDD TQSSGKEEDL
1060 1070 1080 1090 1100
VSEEEDTTSV ASSRAEMDSS DESEESSEYE SSSDSDEKEE EDDEEEELVF
1110 1120 1130 1140 1150
GDDQSEDQDL GQEYEVETDR EEDFFRENLS ECSSLPKAGD VELEDEMQKV
1160 1170 1180 1190 1200
EEDVARQTTQ ETLHLRKKNL DVPLVESKEC KQDTLDKVEK LFAVPMQEEV
1210 1220 1230 1240 1250
FKEHEKAPSP MNEEEEYIEL QLEPVPLVPE GAAPAAQEPV IIRPLTPTGA
1260 1270 1280 1290 1300
FGETGPVLKL EEPKLQVNLT QFATEDEELY PRTPGRDTAA HSDTEVTFQP
1310 1320 1330 1340 1350
GLKVAPSSLP FLPSHNKEEE CLLPPEKHAG HLTVTKMLSE EDLPRTPGRD
1360 1370 1380 1390 1400
IVVKSSHLGK SQSTETVPAT PGSDAPLTGS SLTLTSPHIP GSPFSYLSQS
1410 1420 1430 1440 1450
PGIINSGIPR TPGRDFNFTP TFPESNSIFP CHPSGKKPSV DEPDEKSFKE
1460 1470 1480 1490 1500
PTSASLTMNS VPSPIPFASP PRGLPHMDIR LGADDLESSD TPAYLSDKLL
1510 1520 1530 1540 1550
SEESECEFTK VHLTSTDESA PSPPLPPAEK RKGDRSKKPL SAHEFETEKN
1560 1570 1580 1590 1600
YETSSAVAMS EGALGKQMFI GQPDAVSGIK DPAAVPLDFR NDSLSENTVH
1610 1620 1630 1640 1650
EPIIQKVPLK ELENQWNEVL KEEEDITKHK KSRNSRHNNR YDEFSTVPSP
1660 1670 1680 1690 1700
EFSPPRAMFK PRSEFEEMTI LYDIWNGGID DEDIKYMCIT YDRLLQQDNG
1710 1720 1730 1740 1750
MDWLNDTLWV YHPSTSVYSP KKKKRDDGLR EHVTGCARSE GYYKIDKKDK
1760 1770 1780 1790 1800
LKYLINNRSL TEELPIDTQG KSIPAQPQAS TRAGSERRSE QRRLLSSFTG
1810 1820 1830 1840 1850
SCDSDLLKFN QLKFRKKKLR FCKSHIHDWG LFAMEPIIAD EMVIEYVGQN
1860 1870 1880 1890 1900
IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF ARFINHSCNP
1910 1920 1930 1940 1950
NCYAKVITVE SQKKIVIYSK QYINVNEEIT YDYKFPIEDV KIPCLCGAEN

CRGTLN
Length:1,956
Mass (Da):218,069
Last modified:October 31, 2006 - v1
Checksum:i9AFF263E87E53DCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123932 mRNA. Translation: AAI23933.1.
RefSeqiNP_001072649.1. NM_001079181.1.
UniGeneiStr.52478.

Genome annotation databases

GeneIDi780106.
KEGGixtr:780106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123932 mRNA. Translation: AAI23933.1 .
RefSeqi NP_001072649.1. NM_001079181.1.
UniGenei Str.52478.

3D structure databases

ProteinModelPortali Q08D57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000008143.

Proteomic databases

PaxDbi Q08D57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 780106.
KEGGi xtr:780106.

Organism-specific databases

CTDi 23067.
Xenbasei XB-GENE-5842344. setd1b.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000168216.
HOVERGENi HBG055596.
InParanoidi Q08D57.
KOi K11422.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSET1B_XENTR
AccessioniPrimary (citable) accession number: Q08D57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3