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Q08CY9 (EOGT_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EGF domain-specific O-linked N-acetylglucosamine transferase

EC=2.4.1.255
Alternative name(s):
Extracellular O-linked N-acetylglucosamine transferase
Gene names
Name:eogt
Synonyms:aer61
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.

UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the glycosyltransferase 61 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein O-linked glycosylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein N-acetylglucosaminyltransferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 525507EGF domain-specific O-linked N-acetylglucosamine transferase
PRO_0000301977

Regions

Motif293 – 2953Required for optimal activity By similarity
Motif522 – 5254Prevents secretion from ER Potential

Amino acid modifications

Glycosylation3521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q08CY9 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: DC8F270FDCAE2F88

FASTA52561,427
        10         20         30         40         50         60 
MVPLWLLLLF HVIHFSHGNE IDSAASNGSA LSYHYGKLYL PDDHIPYYLH SNRHIAALCR 

        70         80         90        100        110        120 
RDPHCPFKQH LQNLNSCWGY EKSCTKGHGY SYPVCDQVDF GWAKTIEESQ EVFWKQADFG 

       130        140        150        160        170        180 
YVKERLAETQ ILCRPQEQGD SMLACSRNLQ HCRATNLYLD LRNPRRGQEN FKEDFLQEGE 

       190        200        210        220        230        240 
IGGRCNLDKQ ALLSQGAWKS PLQSWFAELQ SYSSLTFKPV EDAHCDIIID KPTYFMKLDA 

       250        260        270        280        290        300 
GVNMYHHFCD FVNLYITQHV NNSFSTDINI VMWTTSVYGY GDLFSDTWKA FTDYDITHLK 

       310        320        330        340        350        360 
AYDNKRVCFK DAVFALLPRM RYGLFYNTPL ISNCHGSGLF RAFSQHVLHR LNITQQLPKE 

       370        380        390        400        410        420 
AKIRITILVR STEFRKILNL DELVHALEAE PTFQVKVVDY KYRVLGFLEQ LEITHNSDIF 

       430        440        450        460        470        480 
IGMHGAGLTH LLFLPDWAVV FELYNCEDER CYLDLARLRG IRYMTWENRD KVFPQDKGHH 

       490        500        510        520 
PNLGEHPKFT NYAFDVEEFL RLVRQAAKNV SRHSKWPFRR TRDEL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: N6.
Tissue: Oviduct.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC124028 mRNA. Translation: AAI24029.1.
RefSeqNP_001072691.1. NM_001079223.1.
UniGeneStr.53419.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT61. Glycosyltransferase Family 61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID780148.
KEGGxtr:780148.

Organism-specific databases

CTD285203.
XenbaseXB-GENE-994619. eogt.

Phylogenomic databases

HOVERGENHBG056678.
KOK18134.

Family and domain databases

InterProIPR007657. Glycosyltransferase_AER61.
[Graphical view]
PfamPF04577. DUF563. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEOGT_XENTR
AccessionPrimary (citable) accession number: Q08CY9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families