Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase tousled-like 2

Gene

tlk2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of amino acid starvation-induced autophagy.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei416 – 4161ATPPROSITE-ProRule annotation
Active sitei517 – 5171Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi393 – 4019ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tousled-like 2By similarity (EC:2.7.11.1)
Alternative name(s):
Tousled-like kinase 2Imported
Gene namesi
Name:tlk2Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5747259. tlk2.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Serine/threonine-protein kinase tousled-like 2PRO_0000367034Add
BLAST

Proteomic databases

PaxDbiQ08CW1.

Expressioni

Gene expression databases

BgeeiQ08CW1.
ExpressionAtlasiQ08CW1. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000017169.

Structurei

3D structure databases

ProteinModelPortaliQ08CW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini387 – 666280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili264 – 29330Sequence analysisAdd
BLAST
Coiled coili334 – 37239Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1151. Eukaryota.
ENOG410Y3FX. LUCA.
GeneTreeiENSGT00790000123008.
HOGENOMiHOG000259522.
HOVERGENiHBG007938.
InParanoidiQ08CW1.
KOiK08864.
OrthoDBiEOG78H3SF.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR027086. TLK2.
[Graphical view]
PANTHERiPTHR22974:SF20. PTHR22974:SF20. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08CW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEELHSLDP RRQELLEARF TGVGVAKAPL NSESSNQSLC SLGSLSDKEL
60 70 80 90 100
EQTPEKKQND QRNRKRKADP YETSQGKNTP RGHKISDYFE FACGSGPGTS
110 120 130 140 150
PGRSVPPVAR SSPQHSLSNP LPLPSQQCSP PSTAPVNPEH SCASFKHISV
160 170 180 190 200
QHRCTQSDLT MDKISALENS KSSDLEKKEG RIDDLLRVNC DLRRQMDEQK
210 220 230 240 250
KMLEKYKERL NRCVTMSKKL LIEKSKQEKM ACRDKSMQDR LRLGHFTTVR
260 270 280 290 300
HGASFTEQWT DGYAFQNLIK QQERINTQRE EIERQRKMLA KRKPPAMGQT
310 320 330 340 350
PPANNEQKQR KNKTNGAENE ALTLAEYHEQ EEIFKLRLGH LKKEEAEIQA
360 370 380 390 400
ELERLERVRN LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE
410 420 430 440 450
VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE NYHKHACREY RIHKELDHPR
460 470 480 490 500
IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY LKQHKLMTEK EARSIIMQIV
510 520 530 540 550
NALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG LSKIMDDDSY
560 570 580 590 600
NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL
610 620 630 640 650
YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLAYR
660 670 680 690
KEDRIDVQQL ACDPYLLPHI RKSVSTSIPA NAAVASTSGS SNNSLSN
Length:697
Mass (Da):80,071
Last modified:October 31, 2006 - v1
Checksum:i76E1A0B9B75D3D2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124064 mRNA. Translation: AAI24065.1.
RefSeqiNP_001072711.1. NM_001079243.1.
UniGeneiStr.3263.

Genome annotation databases

EnsembliENSXETT00000062296; ENSXETP00000058437; ENSXETG00000007854.
GeneIDi780168.
KEGGixtr:780168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124064 mRNA. Translation: AAI24065.1.
RefSeqiNP_001072711.1. NM_001079243.1.
UniGeneiStr.3263.

3D structure databases

ProteinModelPortaliQ08CW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000017169.

Proteomic databases

PaxDbiQ08CW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000062296; ENSXETP00000058437; ENSXETG00000007854.
GeneIDi780168.
KEGGixtr:780168.

Organism-specific databases

CTDi11011.
XenbaseiXB-GENE-5747259. tlk2.

Phylogenomic databases

eggNOGiKOG1151. Eukaryota.
ENOG410Y3FX. LUCA.
GeneTreeiENSGT00790000123008.
HOGENOMiHOG000259522.
HOVERGENiHBG007938.
InParanoidiQ08CW1.
KOiK08864.
OrthoDBiEOG78H3SF.

Gene expression databases

BgeeiQ08CW1.
ExpressionAtlasiQ08CW1. baseline.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR027086. TLK2.
[Graphical view]
PANTHERiPTHR22974:SF20. PTHR22974:SF20. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6Imported.
    Tissue: SkinImported.

Entry informationi

Entry nameiTLK2_XENTR
AccessioniPrimary (citable) accession number: Q08CW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 31, 2006
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.