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Protein

Serine/threonine-protein kinase tousled-like 2

Gene

tlk2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of amino acid starvation-induced autophagy.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei416ATPPROSITE-ProRule annotation1
Active sitei517Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi393 – 401ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tousled-like 2By similarity (EC:2.7.11.1)
Alternative name(s):
Tousled-like kinase 2Imported
Gene namesi
Name:tlk2Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5747259 tlk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670341 – 697Serine/threonine-protein kinase tousled-like 2Add BLAST697

Proteomic databases

PaxDbiQ08CW1
PRIDEiQ08CW1

Expressioni

Gene expression databases

BgeeiENSXETG00000007854
ExpressionAtlasiQ08CW1 baseline

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000017169

Structurei

3D structure databases

ProteinModelPortaliQ08CW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini387 – 666Protein kinasePROSITE-ProRule annotationAdd BLAST280

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili264 – 293Sequence analysisAdd BLAST30
Coiled coili334 – 372Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1151 Eukaryota
ENOG410Y3FX LUCA
GeneTreeiENSGT00790000123008
HOGENOMiHOG000259522
HOVERGENiHBG007938
InParanoidiQ08CW1
KOiK08864

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR027086 TLK2
PANTHERiPTHR22974:SF20 PTHR22974:SF20, 2 hits
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q08CW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEELHSLDP RRQELLEARF TGVGVAKAPL NSESSNQSLC SLGSLSDKEL
60 70 80 90 100
EQTPEKKQND QRNRKRKADP YETSQGKNTP RGHKISDYFE FACGSGPGTS
110 120 130 140 150
PGRSVPPVAR SSPQHSLSNP LPLPSQQCSP PSTAPVNPEH SCASFKHISV
160 170 180 190 200
QHRCTQSDLT MDKISALENS KSSDLEKKEG RIDDLLRVNC DLRRQMDEQK
210 220 230 240 250
KMLEKYKERL NRCVTMSKKL LIEKSKQEKM ACRDKSMQDR LRLGHFTTVR
260 270 280 290 300
HGASFTEQWT DGYAFQNLIK QQERINTQRE EIERQRKMLA KRKPPAMGQT
310 320 330 340 350
PPANNEQKQR KNKTNGAENE ALTLAEYHEQ EEIFKLRLGH LKKEEAEIQA
360 370 380 390 400
ELERLERVRN LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE
410 420 430 440 450
VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE NYHKHACREY RIHKELDHPR
460 470 480 490 500
IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY LKQHKLMTEK EARSIIMQIV
510 520 530 540 550
NALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG LSKIMDDDSY
560 570 580 590 600
NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL
610 620 630 640 650
YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLAYR
660 670 680 690
KEDRIDVQQL ACDPYLLPHI RKSVSTSIPA NAAVASTSGS SNNSLSN
Length:697
Mass (Da):80,071
Last modified:October 31, 2006 - v1
Checksum:i76E1A0B9B75D3D2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124064 mRNA Translation: AAI24065.1
RefSeqiNP_001072711.1, NM_001079243.1
UniGeneiStr.3263

Genome annotation databases

EnsembliENSXETT00000062296; ENSXETP00000058437; ENSXETG00000007854
GeneIDi780168
KEGGixtr:780168

Similar proteinsi

Entry informationi

Entry nameiTLK2_XENTR
AccessioniPrimary (citable) accession number: Q08CW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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