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Q08CK7

- IF2B1_DANRE

UniProt

Q08CK7 - IF2B1_DANRE

Protein

Insulin-like growth factor 2 mRNA-binding protein 1

Gene

igf2bp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons By similarity. Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Promotes the directed movement of cells by fine-tuning intracellular signaling networks and enhances the velocity of cell migration By similarity.By similarity

    GO - Molecular functioni

    1. mRNA 3'-UTR binding Source: UniProtKB
    2. nucleotide binding Source: InterPro

    GO - Biological processi

    1. mRNA transport Source: UniProtKB-KW
    2. regulation of translation Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Translation regulation, Transport

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 1
    Short name:
    IGF2 mRNA-binding protein 1
    Short name:
    IMP-1
    Alternative name(s):
    IGF-II mRNA-binding protein 1
    VICKZ family member 1
    Gene namesi
    Name:igf2bp1
    Synonyms:vickz1
    ORF Names:zgc:152963
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-060929-1258. igf2bp1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cell projectiongrowth cone By similarity. Cell projectionfilopodium By similarity. Cell projectionlamellipodium By similarity

    GO - Cellular componenti

    1. CRD-mediated mRNA stability complex Source: UniProtKB
    2. filopodium Source: UniProtKB-SubCell
    3. growth cone Source: UniProtKB-SubCell
    4. lamellipodium Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell
    6. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Insulin-like growth factor 2 mRNA-binding protein 1PRO_0000282537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851Phosphoserine1 Publication
    Modified residuei399 – 3991PhosphotyrosineBy similarity
    Modified residuei573 – 5731Phosphothreonine1 Publication
    Modified residuei583 – 5831Phosphothreonine1 Publication
    Modified residuei587 – 5871Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ08CK7.

    Interactioni

    Subunit structurei

    Component of the CRD-mediated complex.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000082159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08CK7.
    SMRiQ08CK7. Positions 1-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7574RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini81 – 15676RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 26366KH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 34668KH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini407 – 47266KH 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini489 – 55567KH 4PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute to transcript binding. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant By similarity.By similarity

    Sequence similaritiesi

    Belongs to the RRM IMP/VICKZ family.Curated
    Contains 4 KH domains.PROSITE-ProRule annotation
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG249985.
    HOGENOMiHOG000000675.
    HOVERGENiHBG052725.
    InParanoidiQ08CK7.
    KOiK17391.
    OrthoDBiEOG7T7GSK.
    PhylomeDBiQ08CK7.

    Family and domain databases

    Gene3Di3.30.1370.10. 4 hits.
    3.30.70.330. 2 hits.
    InterProiIPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00013. KH_1. 4 hits.
    [Graphical view]
    SMARTiSM00322. KH. 4 hits.
    SM00360. RRM. 2 hits.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 4 hits.
    PROSITEiPS50084. KH_TYPE_1. 4 hits.
    PS50102. RRM. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08CK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKLYIGNLN EKVTAEDLVK TFEDYKIPYS GQFLMKTGYA SVDCPDDQWA    50
    MKAIETFSGK VELHGKRIEV EHSVPKKQRT RKLQIRNIPP HLQWEVLDGL 100
    LAQYGTVENC EQVNTDSETA VVNVTYGTRE QARQAIQKLN GYQFDNNALR 150
    VSYIPDENSE VDSQRGPDNG RRPGYGPRGT SRQMSPGSGI PSKHQHADIP 200
    LRLLVPTQYV GAIIGKEGAT IRNITKQTQS KIDVHRKENA GAAEKPISIH 250
    STPEGCSAAC RMILEIMNQE AKDTKTADEV PLKVLAHNNF VGRLIGKEGR 300
    NLKKVEQDTD TKITISPLQD LTLYNPERTI TVKGSIEACC LAEQEIMKKV 350
    REAYDNDIAA MNQQTHLIPG LNLGAIGLFP PSSAMPPPAL GNSVPGPPYG 400
    PMGASEQETV HVYIPAQAVG ALIGKKGQHI KQLSRFAGAS IKIAPAEAPD 450
    SKMRMVIVTG PPEAQFKAQG RIYGKLKEEN FFGPKEEVKL ETHIKVAAAA 500
    AGRVIGKGGK TVNELQNLTA AEVVVPREQT PDEHDQVIVK IIGHFYASQL 550
    AQRKIRDILT QVKQQQKGGG MGTPQGPHPQ GMTELGSPQG LAQEPRRK 598
    Length:598
    Mass (Da):65,530
    Last modified:October 31, 2006 - v1
    Checksum:iCED67F6C29CA2AAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC124196 mRNA. Translation: AAI24197.1.
    RefSeqiNP_001070027.1. NM_001076559.1.
    UniGeneiDr.81351.

    Genome annotation databases

    GeneIDi558182.
    KEGGidre:558182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC124196 mRNA. Translation: AAI24197.1 .
    RefSeqi NP_001070027.1. NM_001076559.1.
    UniGenei Dr.81351.

    3D structure databases

    ProteinModelPortali Q08CK7.
    SMRi Q08CK7. Positions 1-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000082159.

    Proteomic databases

    PRIDEi Q08CK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 558182.
    KEGGi dre:558182.

    Organism-specific databases

    CTDi 10642.
    ZFINi ZDB-GENE-060929-1258. igf2bp1.

    Phylogenomic databases

    eggNOGi NOG249985.
    HOGENOMi HOG000000675.
    HOVERGENi HBG052725.
    InParanoidi Q08CK7.
    KOi K17391.
    OrthoDBi EOG7T7GSK.
    PhylomeDBi Q08CK7.

    Miscellaneous databases

    NextBioi 20882359.
    PROi Q08CK7.

    Family and domain databases

    Gene3Di 3.30.1370.10. 4 hits.
    3.30.70.330. 2 hits.
    InterProi IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00013. KH_1. 4 hits.
    [Graphical view ]
    SMARTi SM00322. KH. 4 hits.
    SM00360. RRM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 4 hits.
    PROSITEi PS50084. KH_TYPE_1. 4 hits.
    PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins."
      Yisraeli J.K.
      Biol. Cell 97:87-96(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    3. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
      Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
      J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185; THR-573; THR-583 AND SER-587, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiIF2B1_DANRE
    AccessioniPrimary (citable) accession number: Q08CK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3