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Q08CK7

- IF2B1_DANRE

UniProt

Q08CK7 - IF2B1_DANRE

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Protein

Insulin-like growth factor 2 mRNA-binding protein 1

Gene

igf2bp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Promotes the directed movement of cells by fine-tuning intracellular signaling networks and enhances the velocity of cell migration (By similarity).By similarity

GO - Molecular functioni

  1. mRNA 3'-UTR binding Source: UniProtKB
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Translation regulation, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor 2 mRNA-binding protein 1
Short name:
IGF2 mRNA-binding protein 1
Short name:
IMP-1
Alternative name(s):
IGF-II mRNA-binding protein 1
VICKZ family member 1
Gene namesi
Name:igf2bp1
Synonyms:vickz1
ORF Names:zgc:152963
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-060929-1258. igf2bp1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cell projectiongrowth cone By similarity. Cell projectionfilopodium By similarity. Cell projectionlamellipodium By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. CRD-mediated mRNA stability complex Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Insulin-like growth factor 2 mRNA-binding protein 1PRO_0000282537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Phosphoserine1 Publication
Modified residuei399 – 3991PhosphotyrosineBy similarity
Modified residuei573 – 5731Phosphothreonine1 Publication
Modified residuei583 – 5831Phosphothreonine1 Publication
Modified residuei587 – 5871Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ08CK7.

Interactioni

Subunit structurei

Component of the CRD-mediated complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000082159.

Structurei

3D structure databases

ProteinModelPortaliQ08CK7.
SMRiQ08CK7. Positions 1-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7574RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 15676RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 26366KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 34668KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini407 – 47266KH 3PROSITE-ProRule annotationAdd
BLAST
Domaini489 – 55567KH 4PROSITE-ProRule annotationAdd
BLAST

Domaini

Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute to transcript binding. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant (By similarity).By similarity

Sequence similaritiesi

Belongs to the RRM IMP/VICKZ family.Curated
Contains 4 KH domains.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG249985.
HOGENOMiHOG000000675.
HOVERGENiHBG052725.
InParanoidiQ08CK7.
KOiK17391.
OrthoDBiEOG7T7GSK.
PhylomeDBiQ08CK7.

Family and domain databases

Gene3Di3.30.1370.10. 4 hits.
3.30.70.330. 2 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00013. KH_1. 4 hits.
[Graphical view]
SMARTiSM00322. KH. 4 hits.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 4 hits.
PROSITEiPS50084. KH_TYPE_1. 4 hits.
PS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08CK7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLYIGNLN EKVTAEDLVK TFEDYKIPYS GQFLMKTGYA SVDCPDDQWA
60 70 80 90 100
MKAIETFSGK VELHGKRIEV EHSVPKKQRT RKLQIRNIPP HLQWEVLDGL
110 120 130 140 150
LAQYGTVENC EQVNTDSETA VVNVTYGTRE QARQAIQKLN GYQFDNNALR
160 170 180 190 200
VSYIPDENSE VDSQRGPDNG RRPGYGPRGT SRQMSPGSGI PSKHQHADIP
210 220 230 240 250
LRLLVPTQYV GAIIGKEGAT IRNITKQTQS KIDVHRKENA GAAEKPISIH
260 270 280 290 300
STPEGCSAAC RMILEIMNQE AKDTKTADEV PLKVLAHNNF VGRLIGKEGR
310 320 330 340 350
NLKKVEQDTD TKITISPLQD LTLYNPERTI TVKGSIEACC LAEQEIMKKV
360 370 380 390 400
REAYDNDIAA MNQQTHLIPG LNLGAIGLFP PSSAMPPPAL GNSVPGPPYG
410 420 430 440 450
PMGASEQETV HVYIPAQAVG ALIGKKGQHI KQLSRFAGAS IKIAPAEAPD
460 470 480 490 500
SKMRMVIVTG PPEAQFKAQG RIYGKLKEEN FFGPKEEVKL ETHIKVAAAA
510 520 530 540 550
AGRVIGKGGK TVNELQNLTA AEVVVPREQT PDEHDQVIVK IIGHFYASQL
560 570 580 590
AQRKIRDILT QVKQQQKGGG MGTPQGPHPQ GMTELGSPQG LAQEPRRK
Length:598
Mass (Da):65,530
Last modified:October 31, 2006 - v1
Checksum:iCED67F6C29CA2AAD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC124196 mRNA. Translation: AAI24197.1.
RefSeqiNP_001070027.1. NM_001076559.1.
UniGeneiDr.81351.

Genome annotation databases

GeneIDi558182.
KEGGidre:558182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC124196 mRNA. Translation: AAI24197.1 .
RefSeqi NP_001070027.1. NM_001076559.1.
UniGenei Dr.81351.

3D structure databases

ProteinModelPortali Q08CK7.
SMRi Q08CK7. Positions 1-157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000082159.

Proteomic databases

PRIDEi Q08CK7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 558182.
KEGGi dre:558182.

Organism-specific databases

CTDi 10642.
ZFINi ZDB-GENE-060929-1258. igf2bp1.

Phylogenomic databases

eggNOGi NOG249985.
HOGENOMi HOG000000675.
HOVERGENi HBG052725.
InParanoidi Q08CK7.
KOi K17391.
OrthoDBi EOG7T7GSK.
PhylomeDBi Q08CK7.

Miscellaneous databases

NextBioi 20882359.
PROi Q08CK7.

Family and domain databases

Gene3Di 3.30.1370.10. 4 hits.
3.30.70.330. 2 hits.
InterProi IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00013. KH_1. 4 hits.
[Graphical view ]
SMARTi SM00322. KH. 4 hits.
SM00360. RRM. 2 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 4 hits.
PROSITEi PS50084. KH_TYPE_1. 4 hits.
PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins."
    Yisraeli J.K.
    Biol. Cell 97:87-96(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  3. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
    Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
    J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185; THR-573; THR-583 AND SER-587, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiIF2B1_DANRE
AccessioniPrimary (citable) accession number: Q08CK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3