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Q08CI8 (S238A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 25 member 38-A
Gene names
Name:slc25a38a
ORF Names:zgc:153036
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane By similarity. HAMAP-Rule MF_03064

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_03064.

Disruption phenotype

Fishes lacking both slc25a38a and slc25a38b display anemia. Ref.3

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Solute carrier family 25 member 38-A HAMAP-Rule MF_03064
PRO_0000291805

Regions

Transmembrane13 – 3826Helical; Name=1; Potential
Transmembrane72 – 9827Helical; Name=2; Potential
Transmembrane110 – 13526Helical; Name=3; Potential
Transmembrane163 – 18624Helical; Name=4; Potential
Transmembrane202 – 22827Helical; Name=5; Potential
Transmembrane257 – 27519Helical; Name=6; Potential
Repeat7 – 9791Solcar 1 HAMAP-Rule MF_03064
Repeat104 – 18885Solcar 2 HAMAP-Rule MF_03064
Repeat198 – 28285Solcar 3 HAMAP-Rule MF_03064

Experimental info

Sequence conflict411Q → H in AAI24223. Ref.2
Sequence conflict971R → H in AAI24223. Ref.2
Sequence conflict1871H → N in AAI24223. Ref.2
Sequence conflict2831I → M in AAI24223. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q08CI8 [UniParc].

Last modified February 19, 2014. Version 2.
Checksum: 1429A9E8EB10C528

FASTA28731,161
        10         20         30         40         50         60 
MEFSVAHPAV KAFMCGSLSG TCSTLLFQPL DLVKTRLQTL QSGVQPGTGR VGMVTVFVNV 

        70         80         90        100        110        120 
LRTEKLLGLW RGVSPSFVRC IPGVGIYFST YFTLKQRYFS SGAPGPLQAV LLGAGARCVA 

       130        140        150        160        170        180 
GVFMLPVTVI KTRFESGRYR YSGVFGALRS VCQTEGPKAL FSGLMATLLR DAPFSGIYVM 

       190        200        210        220        230        240 
IYSQTKHLLP PEISQSSYAP VANFSCGVLA GVLASVLTQP ADVVKTHIQV SPDVFSRTSD 

       250        260        270        280 
VVRYIYKEHG LVGFFRGAVP RSLRRTMMAA MAWTVYEQLM AQIGLKS 

« Hide

References

« Hide 'large scale' references
[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Intestine.
[3]"Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia."
Guernsey D.L., Jiang H., Campagna D.R., Evans S.C., Ferguson M., Kellogg M.D., Lachance M., Matsuoka M., Nightingale M., Rideout A., Saint-Amant L., Schmidt P.J., Orr A., Bottomley S.S., Fleming M.D., Ludman M., Dyack S., Fernandez C.V., Samuels M.E.
Nat. Genet. 41:651-653(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CABZ01034848 Genomic DNA. No translation available.
CABZ01034849 Genomic DNA. No translation available.
BC124222 mRNA. Translation: AAI24223.1.
RefSeqNP_001070070.1. NM_001076602.1.
UniGeneDr.83274.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000083532; ENSDARP00000077967; ENSDARG00000059805.
GeneID767662.
KEGGdre:767662.

Organism-specific databases

CTD767662.
ZFINZDB-GENE-060929-320. slc25a38a.

Phylogenomic databases

GeneTreeENSGT00550000075117.
HOGENOMHOG000006978.
InParanoidQ08CI8.
KOK15118.
OMAIKTRFEC.
OrthoDBEOG7BGHMD.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
HAMAPMF_03064. SLC25A38.
InterProIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20918055.

Entry information

Entry nameS238A_DANRE
AccessionPrimary (citable) accession number: Q08CI8
Secondary accession number(s): F1QG50
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 19, 2014
Last modified: July 9, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families