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Protein

Solute carrier family 25 member 38-A

Gene

slc25a38a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • erythrocyte differentiation Source: UniProtKB
  • heme biosynthetic process Source: UniProtKB-HAMAP
  • hemoglobin metabolic process Source: ZFIN
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38-AUniRule annotation
Gene namesi
Name:slc25a38a
ORF Names:zgc:153036
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-060929-320. slc25a38a.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3826Helical; Name=1UniRule annotationAdd
BLAST
Transmembranei72 – 9827Helical; Name=2UniRule annotationAdd
BLAST
Transmembranei110 – 13526Helical; Name=3UniRule annotationAdd
BLAST
Transmembranei163 – 18624Helical; Name=4UniRule annotationAdd
BLAST
Transmembranei202 – 22827Helical; Name=5UniRule annotationAdd
BLAST
Transmembranei257 – 27519Helical; Name=6UniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Fishes lacking both slc25a38a and slc25a38b display anemia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Solute carrier family 25 member 38-APRO_0000291805Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077967.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 9791Solcar 1Add
BLAST
Repeati104 – 18885Solcar 2Add
BLAST
Repeati198 – 28285Solcar 3Add
BLAST

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
Contains 3 Solcar repeats.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
InParanoidiQ08CI8.
KOiK15118.
OMAiTVYEQIM.
OrthoDBiEOG7BGHMD.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08CI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSVAHPAV KAFMCGSLSG TCSTLLFQPL DLVKTRLQTL QSGVQPGTGR
60 70 80 90 100
VGMVTVFVNV LRTEKLLGLW RGVSPSFVRC IPGVGIYFST YFTLKQRYFS
110 120 130 140 150
SGAPGPLQAV LLGAGARCVA GVFMLPVTVI KTRFESGRYR YSGVFGALRS
160 170 180 190 200
VCQTEGPKAL FSGLMATLLR DAPFSGIYVM IYSQTKHLLP PEISQSSYAP
210 220 230 240 250
VANFSCGVLA GVLASVLTQP ADVVKTHIQV SPDVFSRTSD VVRYIYKEHG
260 270 280
LVGFFRGAVP RSLRRTMMAA MAWTVYEQLM AQIGLKS
Length:287
Mass (Da):31,161
Last modified:February 19, 2014 - v2
Checksum:i1429A9E8EB10C528
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411Q → H in AAI24223 (Ref. 2) Curated
Sequence conflicti97 – 971R → H in AAI24223 (Ref. 2) Curated
Sequence conflicti187 – 1871H → N in AAI24223 (Ref. 2) Curated
Sequence conflicti283 – 2831I → M in AAI24223 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01034848 Genomic DNA. No translation available.
CABZ01034849 Genomic DNA. No translation available.
BC124222 mRNA. Translation: AAI24223.1.
RefSeqiNP_001070070.1. NM_001076602.1.
UniGeneiDr.83274.

Genome annotation databases

EnsembliENSDART00000083532; ENSDARP00000077967; ENSDARG00000059805.
GeneIDi767662.
KEGGidre:767662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01034848 Genomic DNA. No translation available.
CABZ01034849 Genomic DNA. No translation available.
BC124222 mRNA. Translation: AAI24223.1.
RefSeqiNP_001070070.1. NM_001076602.1.
UniGeneiDr.83274.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000083532; ENSDARP00000077967; ENSDARG00000059805.
GeneIDi767662.
KEGGidre:767662.

Organism-specific databases

CTDi767662.
ZFINiZDB-GENE-060929-320. slc25a38a.

Phylogenomic databases

GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
InParanoidiQ08CI8.
KOiK15118.
OMAiTVYEQIM.
OrthoDBiEOG7BGHMD.

Miscellaneous databases

NextBioi20918055.
PROiQ08CI8.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Intestine.
  3. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiS238A_DANRE
AccessioniPrimary (citable) accession number: Q08CI8
Secondary accession number(s): F1QG50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 19, 2014
Last modified: June 24, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.