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Q08CI8

- S238A_DANRE

UniProt

Q08CI8 - S238A_DANRE

Protein

Solute carrier family 25 member 38-A

Gene

slc25a38a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (19 Feb 2014)
      Previous versions | rss
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    Functioni

    Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

    GO - Biological processi

    1. erythrocyte differentiation Source: UniProtKB
    2. hemoglobin metabolic process Source: ZFIN
    3. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 25 member 38-AUniRule annotation
    Gene namesi
    Name:slc25a38a
    ORF Names:zgc:153036
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 3, UP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-060929-320. slc25a38a.

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Fishes lacking both slc25a38a and slc25a38b display anemia.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Solute carrier family 25 member 38-APRO_0000291805Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3826Helical; Name=1UniRule annotationAdd
    BLAST
    Transmembranei72 – 9827Helical; Name=2UniRule annotationAdd
    BLAST
    Transmembranei110 – 13526Helical; Name=3UniRule annotationAdd
    BLAST
    Transmembranei163 – 18624Helical; Name=4UniRule annotationAdd
    BLAST
    Transmembranei202 – 22827Helical; Name=5UniRule annotationAdd
    BLAST
    Transmembranei257 – 27519Helical; Name=6UniRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati7 – 9791Solcar 1Add
    BLAST
    Repeati104 – 18885Solcar 2Add
    BLAST
    Repeati198 – 28285Solcar 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
    Contains 3 Solcar repeats.UniRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00550000075117.
    HOGENOMiHOG000006978.
    InParanoidiQ08CI8.
    KOiK15118.
    OMAiIKTRFEC.
    OrthoDBiEOG7BGHMD.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    HAMAPiMF_03064. SLC25A38.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08CI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSVAHPAV KAFMCGSLSG TCSTLLFQPL DLVKTRLQTL QSGVQPGTGR    50
    VGMVTVFVNV LRTEKLLGLW RGVSPSFVRC IPGVGIYFST YFTLKQRYFS 100
    SGAPGPLQAV LLGAGARCVA GVFMLPVTVI KTRFESGRYR YSGVFGALRS 150
    VCQTEGPKAL FSGLMATLLR DAPFSGIYVM IYSQTKHLLP PEISQSSYAP 200
    VANFSCGVLA GVLASVLTQP ADVVKTHIQV SPDVFSRTSD VVRYIYKEHG 250
    LVGFFRGAVP RSLRRTMMAA MAWTVYEQLM AQIGLKS 287
    Length:287
    Mass (Da):31,161
    Last modified:February 19, 2014 - v2
    Checksum:i1429A9E8EB10C528
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411Q → H in AAI24223. 1 PublicationCurated
    Sequence conflicti97 – 971R → H in AAI24223. 1 PublicationCurated
    Sequence conflicti187 – 1871H → N in AAI24223. 1 PublicationCurated
    Sequence conflicti283 – 2831I → M in AAI24223. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CABZ01034848 Genomic DNA. No translation available.
    CABZ01034849 Genomic DNA. No translation available.
    BC124222 mRNA. Translation: AAI24223.1.
    RefSeqiNP_001070070.1. NM_001076602.1.
    UniGeneiDr.83274.

    Genome annotation databases

    EnsembliENSDART00000083532; ENSDARP00000077967; ENSDARG00000059805.
    GeneIDi767662.
    KEGGidre:767662.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CABZ01034848 Genomic DNA. No translation available.
    CABZ01034849 Genomic DNA. No translation available.
    BC124222 mRNA. Translation: AAI24223.1 .
    RefSeqi NP_001070070.1. NM_001076602.1.
    UniGenei Dr.83274.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000083532 ; ENSDARP00000077967 ; ENSDARG00000059805 .
    GeneIDi 767662.
    KEGGi dre:767662.

    Organism-specific databases

    CTDi 767662.
    ZFINi ZDB-GENE-060929-320. slc25a38a.

    Phylogenomic databases

    GeneTreei ENSGT00550000075117.
    HOGENOMi HOG000006978.
    InParanoidi Q08CI8.
    KOi K15118.
    OMAi IKTRFEC.
    OrthoDBi EOG7BGHMD.

    Miscellaneous databases

    NextBioi 20918055.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    HAMAPi MF_03064. SLC25A38.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Intestine.
    3. Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiS238A_DANRE
    AccessioniPrimary (citable) accession number: Q08CI8
    Secondary accession number(s): F1QG50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: February 19, 2014
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3