ID   EZH2_DANRE              Reviewed;         760 AA.
AC   Q08BS4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Histone-lysine N-methyltransferase EZH2;
DE            EC=2.1.1.43;
DE   AltName: Full=Enhancer of zeste homolog 2;
GN   Name=ezh2; Synonyms=zgc:152758;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein (By similarity). Catalytic
CC       subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and
CC       'Lys-27' of histone H3, leading to transcriptional repression of
CC       the affected target gene (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine =
CC       S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the histone-lysine methyltransferase
CC       family. EZ subfamily.
CC   -!- SIMILARITY: Contains 1 SET domain.
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DR   EMBL; BC124588; AAI24589.1; -; mRNA.
DR   IPI; IPI00805646; -.
DR   RefSeq; NP_001070747.1; -.
DR   UniGene; Dr.76424; -.
DR   PRIDE; Q08BS4; -.
DR   Ensembl; ENSDARG00000010571; Danio rerio.
DR   GeneID; 768133; -.
DR   KEGG; dre:768133; -.
DR   ZFIN; ZDB-GENE-041111-259; ezh2.
DR   HOVERGEN; Q08BS4; -.
DR   Bgee; Q08BS4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001005; SANT_DNA-bd.
DR   InterPro; IPR001214; SET.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00717; SANT; 2.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Methyltransferase; Nucleus; Repressor;
KW   S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN         1    760       Histone-lysine N-methyltransferase EZH2.
FT                                /FTId=PRO_0000345427.
FT   DOMAIN      625    745       SET.
FT   COMPBIAS    537    602       Cys-rich.
SQ   SEQUENCE   760 AA;  87145 MW;  E04C67897A59905F CRC64;
     MGLTGRKSEK GPVCWRRRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTDILNQEW
     KLRRIQPVHI MTPVSSLRGT RECTVDSGFS EFSRQVIPLK TLNAVASVPV MYSWSPLQQN
     FMVEDETVLH NIPYMGDEIL DQDGTFIEEL IKNYDGKVHG DRECGFINDE IFVELVNALN
     QYSDNEEDDE EDDHHDYKFE KMDLCDGKDD AEDHKEQLSS ESHNNDGSKK FPSDKIFEAI
     SSMFPDKGST EELKEKYKEL TEQQLPGALP PECTPNIDGP NAKSVQREQS LHSFHTLFCR
     RCFKYDCFLH PFQATPNTYK RKNMENLVDS KPCGIYCYMY MVQDGMVREY PAGVVPERAK
     TPSKRSTGRR RGRLPNSNSR PSTPTVNSET KDTDSDREGG ADGNDSNDKD DDDKKDETTS
     SSEANSRCQT PVKLKLSSEP PENVDWSGAE ASLFRVLIGT YYDNFCAIAR LIGTKTCRQV
     YEFRVKESSI IARAPAVDEN TPQRKKKRKH RLWATHCRKI QLKKDGSSNH VYNYQPCDHP
     RQPCDSSCPC VTAQNFCEKF CQCSSECQNR FPGCRCKAQC NTKQCPCYLA VRECDPDLCL
     TCGAAEHWDS KNVSCKNCSI QRGAKKHLLL APSDVAGWGI FIKEPVQKNE FISEYCGEII
     SQDEADRRGK VYDKYMCSFL FNLNNDFVVD ATRKGNKIRF ANHSVNPNCY AKVMMVNGDH
     RIGIFAKRAI QTGEELFFDY RYSQADALKY VGIEREMEIP
//