Reviewed, UniProtKB/Swiss-Prot Q08BS4 (EZH2_DANRE)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase EZH2
    EC=2.1.1.43
Alternative name(s):
    Enhancer of zeste homolog 2

Gene names

Name:	ezh2
Synonyms:	zgc:152758

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	760 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Polycomb group (PcG) protein By similarity. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subunit structure	Component of the prc2/eed-ezh2 complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Repressor Transferase
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 760	760	Histone-lysine N-methyltransferase EZH2		PRO_0000345427
Regions
	Domain	625 – 745	121	SET
	Compositional bias	537 – 602	66	Cys-rich

Sequences

	Sequence		Length	Mass (Da)
	Q08BS4-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: E04C67897A59905F	FASTA	760	87,145
	10 20 30 40 50 60 MGLTGRKSEK GPVCWRRRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTDILNQEW 70 80 90 100 110 120 KLRRIQPVHI MTPVSSLRGT RECTVDSGFS EFSRQVIPLK TLNAVASVPV MYSWSPLQQN 130 140 150 160 170 180 FMVEDETVLH NIPYMGDEIL DQDGTFIEEL IKNYDGKVHG DRECGFINDE IFVELVNALN 190 200 210 220 230 240 QYSDNEEDDE EDDHHDYKFE KMDLCDGKDD AEDHKEQLSS ESHNNDGSKK FPSDKIFEAI 250 260 270 280 290 300 SSMFPDKGST EELKEKYKEL TEQQLPGALP PECTPNIDGP NAKSVQREQS LHSFHTLFCR 310 320 330 340 350 360 RCFKYDCFLH PFQATPNTYK RKNMENLVDS KPCGIYCYMY MVQDGMVREY PAGVVPERAK 370 380 390 400 410 420 TPSKRSTGRR RGRLPNSNSR PSTPTVNSET KDTDSDREGG ADGNDSNDKD DDDKKDETTS 430 440 450 460 470 480 SSEANSRCQT PVKLKLSSEP PENVDWSGAE ASLFRVLIGT YYDNFCAIAR LIGTKTCRQV 490 500 510 520 530 540 YEFRVKESSI IARAPAVDEN TPQRKKKRKH RLWATHCRKI QLKKDGSSNH VYNYQPCDHP 550 560 570 580 590 600 RQPCDSSCPC VTAQNFCEKF CQCSSECQNR FPGCRCKAQC NTKQCPCYLA VRECDPDLCL 610 620 630 640 650 660 TCGAAEHWDS KNVSCKNCSI QRGAKKHLLL APSDVAGWGI FIKEPVQKNE FISEYCGEII 670 680 690 700 710 720 SQDEADRRGK VYDKYMCSFL FNLNNDFVVD ATRKGNKIRF ANHSVNPNCY AKVMMVNGDH 730 740 750 760 RIGIFAKRAI QTGEELFFDY RYSQADALKY VGIEREMEIP

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC124588 mRNA. Translation: AAI24589.1.
IPI	IPI00805646.
RefSeq	NP_001070747.1.
UniGene	Dr.76424
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q08BS4.
Genome annotation databases
Ensembl	ENSDARG00000010571. Danio rerio. [Contig view]
GeneID	768133.
KEGG	dre:768133.
Organism-specific databases
ZFIN	ZDB-GENE-041111-259. ezh2.
Phylogenomic databases
HOVERGEN	Q08BS4.
Gene expression databases
Bgee	Q08BS4.
Family and domain databases
InterPro	IPR001005. SANT_DNA-bd. IPR001214. SET. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00717. SANT. 2 hits. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EZH2_DANRE

Accession

Primary (citable) accession number: Q08BS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	October 31, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project