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Protein

Enolase 4

Gene

eno4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2-phospho-D-glycerate = phosphoenolpyruvate + H2O.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.By similarity
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gapdhs), Glyceraldehyde-3-phosphate dehydrogenase 2 (gapdh-2), Glyceraldehyde-3-phosphate dehydrogenase (gapdh), Glyceraldehyde-3-phosphate dehydrogenase (gapdh)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Enolase 4 (eno4)
  5. Pyruvate kinase, Pyruvate kinase, Pyruvate kinase, Pyruvate kinase (pkmb), Pyruvate kinase, Pyruvate kinase (pkma), Pyruvate kinase (pkma), Pyruvate kinase (pklr), Pyruvate kinase (pklr), Pyruvate kinase (pkmb), Pyruvate kinase (pkma)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei302SubstrateBy similarity1
Binding sitei524SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00187.

Names & Taxonomyi

Protein namesi
Recommended name:
Enolase 4 (EC:4.2.1.11)
Alternative name(s):
2-phospho-D-glycerate hydro-lyase
Gene namesi
Name:eno4
ORF Names:zgc:153973
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061013-677. eno4.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003484561 – 576Enolase 4Add BLAST576

Proteomic databases

PaxDbiQ08BC6.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094621.

Structurei

3D structure databases

ProteinModelPortaliQ08BC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the enolase family.Curated

Phylogenomic databases

eggNOGiKOG2670. Eukaryota.
COG0148. LUCA.
HOGENOMiHOG000168691.
HOVERGENiHBG107850.
InParanoidiQ08BC6.
PhylomeDBiQ08BC6.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiView protein in InterPro
IPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020811. Enolase_N.
IPR029017. Enolase_N-like.
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiView protein in Pfam
PF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
SMARTiView protein in SMART
SM01192. Enolase_C. 1 hit.
SM01193. Enolase_N. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 2 hits.

Sequencei

Sequence statusi: Complete.

Q08BC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKGFPSHS KVSKEDQEFY DLKNKAAEYY RSNGVPQKIE SVLNEMFWQK
60 70 80 90 100
PDDIYGYLAN YFSGLSYTPV ISKITGKEVF DGRGLTAVQA EVHCIIRNEE
110 120 130 140 150
KMVCGAVMDG SFDGLPDGVE SGEMLSNGDL QHLSITMALK WIRENFSPVL
160 170 180 190 200
RGFNPTDQTN VDKILSDFAM ARYLEHKDSL IREKEEELRN EAMSEAPPQA
210 220 230 240 250
TPTSAPAKDK KGNDKGKKGN ITENPLPPAE PPVPRLPGAT AVGAVSLAVA
260 270 280 290 300
KTAAELLGTP LYRHITAVRD PQAQKEMQLP VPIITIMSCG KNSAGKLNLL
310 320 330 340 350
EEIILMPSSS LRVREVIGMG LDLQCEMRRI LNGSTYKALP VGVSDEGALQ
360 370 380 390 400
VGFDRPEQAL DLLAEACANL ALPLGSDLHL AVNCAAHSLM DYSRGKYEVM
410 420 430 440 450
SGCHKSPDEL VDIYEGLINK YPAIRSLIDP FRKEDVGQWE RLASVIGQSC
460 470 480 490 500
CLLADAASNL CPRWREAKPL PPGATKAIIR HHSDMTISDL IQSIAEHKET
510 520 530 540 550
ILAAGSGDAS MVDLAVGSGV SFLKLGGLRG AKRMDKYNRL MAIEEEQEGI
560 570
AGAGEINQPV SFESESGWNS LTVSAK
Length:576
Mass (Da):62,768
Last modified:October 31, 2006 - v1
Checksum:iB3FDEAA48C6F1612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124782 mRNA. Translation: AAI24783.1.
RefSeqiNP_001071015.1. NM_001077547.1.
UniGeneiDr.150750.

Genome annotation databases

GeneIDi558487.
KEGGidre:558487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124782 mRNA. Translation: AAI24783.1.
RefSeqiNP_001071015.1. NM_001077547.1.
UniGeneiDr.150750.

3D structure databases

ProteinModelPortaliQ08BC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094621.

Proteomic databases

PaxDbiQ08BC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi558487.
KEGGidre:558487.

Organism-specific databases

CTDi387712.
ZFINiZDB-GENE-061013-677. eno4.

Phylogenomic databases

eggNOGiKOG2670. Eukaryota.
COG0148. LUCA.
HOGENOMiHOG000168691.
HOVERGENiHBG107850.
InParanoidiQ08BC6.
PhylomeDBiQ08BC6.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00187.

Miscellaneous databases

PROiPR:Q08BC6.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiView protein in InterPro
IPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020811. Enolase_N.
IPR029017. Enolase_N-like.
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiView protein in Pfam
PF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
SMARTiView protein in SMART
SM01192. Enolase_C. 1 hit.
SM01193. Enolase_N. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiENO4_DANRE
AccessioniPrimary (citable) accession number: Q08BC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2006
Last modified: May 10, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although it is highly related to enolase enzyme family, lacks the conserved Glu active site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.