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Q08B31 (P4K2A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylinositol 4-kinase type 2-alpha
EC=2.7.1.67
Alternative name(s):
Phosphatidylinositol 4-kinase type II-alpha
Gene names
Name:pi4k2a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Subcellular location

Cytoplasm By similarity. Membrane By similarity.

Sequence similarities

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function1-phosphatidylinositol 4-kinase activity

Inferred from electronic annotation. Source: EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Phosphatidylinositol 4-kinase type 2-alpha
PRO_0000285162

Regions

Domain124 – 428305PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
Q08B31 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: DD9B4F285E4DCDB3

FASTA46953,206
        10         20         30         40         50         60 
MDETSPLVSP DRDQTEYSYQ SQCSPGATVP LSPNGRFSAL PGVVVRIPGT ATSCGSAASG 

        70         80         90        100        110        120 
PSPPGSPCDQ ERQPLLERSQ TRAAAAQAER EMNKFPDDPA FAEVVKKAEK AIMRDILPER 

       130        140        150        160        170        180 
ISQGSSGSYF VKDEQGEIIA VFKPKNEEPY GQLNPKWTKW LQKLCCPCCF GRDCLVLNQG 

       190        200        210        220        230        240 
YLSEAGASLV DQKLDLNIVP RTKVVFLASE TFNYSAIDRV KSRGKRLALE KVPKVGQRFN 

       250        260        270        280        290        300 
RIGLPPKVGS FQIFVKSYKD ADYWLRRFEA DPLPENTNRQ LQLQFERLVV LDYIIRNTDR 

       310        320        330        340        350        360 
GNDNWLIKYD CPMDSASARD DWVMVKEPVI KIAAIDNGLA FPLKHPDSWR AYPFYWAWLP 

       370        380        390        400        410        420 
QAKIQFSQEI KDLILPKISD PNFVKDLEED LYELFKKDQG FDRGQFRKQI AVMRGQILNL 

       430        440        450        460 
TQAMKDGKSP LQLVQTPPVI VETARSHQKS TSESYTQSFQ SRKPFFSWW

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC124897 mRNA. Translation: AAI24898.1.
RefSeqNP_001121279.1. NM_001127807.1.
UniGeneXl.50976.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100158362.
KEGGxla:100158362.

Organism-specific databases

CTD55361.
XenbaseXB-GENE-866066. pi4k2a.

Phylogenomic databases

HOVERGENHBG059542.

Family and domain databases

InterProIPR000403. PI3/4_kinase_cat.
[Graphical view]
KOK13711.
PfamPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
PROSITEPS00915. PI3_4_KINASE_1. False negative.
PS00916. PI3_4_KINASE_2. False negative.
PS50290. PI3_4_KINASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP4K2A_XENLA
AccessionPrimary (citable) accession number: Q08B31
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 31, 2006
Last modified: November 16, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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