Reviewed, UniProtKB/Swiss-Prot Q08B31 (P4K2A_XENLA)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol 4-kinase type 2-alpha
    EC=2.7.1.67
Alternative name(s):
    Phosphatidylinositol 4-kinase type II-alpha

Gene names

Name:

pi4k2a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Subcellular location	Cytoplasm By similarity. Membrane By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-phosphatidylinositol 4-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Phosphatidylinositol 4-kinase type 2-alpha		PRO_0000285162
Regions
	Domain	124 – 428	305	PI3K/PI4K

Sequences

	Sequence		Length	Mass (Da)
	Q08B31-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: DD9B4F285E4DCDB3	FASTA	469	53,206
	10 20 30 40 50 60 MDETSPLVSP DRDQTEYSYQ SQCSPGATVP LSPNGRFSAL PGVVVRIPGT ATSCGSAASG 70 80 90 100 110 120 PSPPGSPCDQ ERQPLLERSQ TRAAAAQAER EMNKFPDDPA FAEVVKKAEK AIMRDILPER 130 140 150 160 170 180 ISQGSSGSYF VKDEQGEIIA VFKPKNEEPY GQLNPKWTKW LQKLCCPCCF GRDCLVLNQG 190 200 210 220 230 240 YLSEAGASLV DQKLDLNIVP RTKVVFLASE TFNYSAIDRV KSRGKRLALE KVPKVGQRFN 250 260 270 280 290 300 RIGLPPKVGS FQIFVKSYKD ADYWLRRFEA DPLPENTNRQ LQLQFERLVV LDYIIRNTDR 310 320 330 340 350 360 GNDNWLIKYD CPMDSASARD DWVMVKEPVI KIAAIDNGLA FPLKHPDSWR AYPFYWAWLP 370 380 390 400 410 420 QAKIQFSQEI KDLILPKISD PNFVKDLEED LYELFKKDQG FDRGQFRKQI AVMRGQILNL 430 440 450 460 TQAMKDGKSP LQLVQTPPVI VETARSHQKS TSESYTQSFQ SRKPFFSWW

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC124897 mRNA. Translation: AAI24898.1.
RefSeq	NP_001121279.1.
UniGene	Xl.50976
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100158362.
KEGG	xla:100158362.
Organism-specific databases
CTD	100158362.
Xenbase	XB-FEAT-491467. pi4k2a.
Phylogenomic databases
HOVERGEN	Q08B31.
Enzyme and pathway databases
BRENDA	2.7.1.67. 648.
Family and domain databases
InterPro	IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. [Graphical view]
Pfam	PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
PROSITE	PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. False negative. PS50290. PI3_4_KINASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P4K2A_XENLA

Accession

Primary (citable) accession number: Q08B31

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	October 31, 2006
Last modified:	October 13, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project