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Q08B22 (ALG11_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:alg11
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionGDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q08B22-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q08B22-2)

The sequence of this isoform differs from the canonical sequence as follows:
     398-486: IVECMAAGTI...FLASSEPLFK → ESLAILFCKHIIASINILLMDA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000295620

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane230 – 25021Helical; Potential

Natural variations

Alternative sequence398 – 48689IVECM…EPLFK → ESLAILFCKHIIASINILLM DA in isoform 2.
VSP_026942

Experimental info

Sequence conflict241T → A in AAH97779. Ref.1
Sequence conflict951V → I in AAI06204. Ref.1
Sequence conflict3271A → T in AAI06204. Ref.1
Sequence conflict4451H → R in AAI06204. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 36A3917D1479F946

FASTA48654,709
        10         20         30         40         50         60 
MAGPMCLCGM MRLLTALFIP VLITSVGLCL IFVLLFICTR LWVQRKKKVE IGKDGKKKKV 

        70         80         90        100        110        120 
VAFFHPYCNA GGGGERVLWC ALRSLQKRYK DAIYVIYTGD KDASEEQILN GAAARFNIKL 

       130        140        150        160        170        180 
SHPVRFIFLE KRGLVEASCY PRFTLLGQSL GSVVLGWEAL TKCVPDIYID SMGYAFTLPL 

       190        200        210        220        230        240 
FKYLGGCHVG CYVHYPTISM DMLSVVRSQH ARFNNAAFIS NNPVLSRLKL IYYYLFALFY 

       250        260        270        280        290        300 
GWVGSCSDVI MVNSTWTFSH ILDLWKCSDR TSIVYPPCDV QTFLEIDINQ HKENEEHSVV 

       310        320        330        340        350        360 
SIGQFRPEKD HPLQIRAFAA LLEKKTAEQR AKLKLILIGG CRNDEDELRV SELKKLSSEL 

       370        380        390        400        410        420 
GIPVEFKVNV PFEELKKHLS EATIGLHTMW NEHFGIGIVE CMAAGTIILA HNSGGPKLDI 

       430        440        450        460        470        480 
VVPHEEQQTG FLADSVDSYA AAMDHILSLT PEQRLSIRQN ARLSVGRFSD QEFEANFLAS 


SEPLFK 

« Hide

Isoform 2 [UniParc].

Checksum: CEDFBC65662DBE6C
Show »

FASTA41947,436

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Egg, Embryo and Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097779 mRNA. Translation: AAH97779.1.
BC106203 mRNA. Translation: AAI06204.1.
BC124907 mRNA. Translation: AAI24908.1.
RefSeqNP_001116360.1. NM_001122888.1. [Q08B22-2]
UniGeneXl.53984.
Xl.59560.

3D structure databases

ProteinModelPortalQ08B22.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT4. Glycosyltransferase Family 4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID733388.
KEGGxla:733388.

Organism-specific databases

CTD440138.
XenbaseXB-GENE-5934162. alg11.

Phylogenomic databases

HOVERGENHBG057178.
KOK03844.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG11_XENLA
AccessionPrimary (citable) accession number: Q08B22
Secondary accession number(s): Q3B8M7, Q4QQZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families