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Q08B22

- ALG11_XENLA

UniProt

Q08B22 - ALG11_XENLA

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg11

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT4. Glycosyltransferase Family 4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Asparagine-linked glycosylation protein 11 homolog
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:alg11
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5934162. alg11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000295620Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ08B22.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG057178.
    KOiK03844.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q08B22-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPMCLCGM MRLLTALFIP VLITSVGLCL IFVLLFICTR LWVQRKKKVE    50
    IGKDGKKKKV VAFFHPYCNA GGGGERVLWC ALRSLQKRYK DAIYVIYTGD 100
    KDASEEQILN GAAARFNIKL SHPVRFIFLE KRGLVEASCY PRFTLLGQSL 150
    GSVVLGWEAL TKCVPDIYID SMGYAFTLPL FKYLGGCHVG CYVHYPTISM 200
    DMLSVVRSQH ARFNNAAFIS NNPVLSRLKL IYYYLFALFY GWVGSCSDVI 250
    MVNSTWTFSH ILDLWKCSDR TSIVYPPCDV QTFLEIDINQ HKENEEHSVV 300
    SIGQFRPEKD HPLQIRAFAA LLEKKTAEQR AKLKLILIGG CRNDEDELRV 350
    SELKKLSSEL GIPVEFKVNV PFEELKKHLS EATIGLHTMW NEHFGIGIVE 400
    CMAAGTIILA HNSGGPKLDI VVPHEEQQTG FLADSVDSYA AAMDHILSLT 450
    PEQRLSIRQN ARLSVGRFSD QEFEANFLAS SEPLFK 486
    Length:486
    Mass (Da):54,709
    Last modified:July 24, 2007 - v2
    Checksum:i36A3917D1479F946
    GO
    Isoform 2 (identifier: Q08B22-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         398-486: IVECMAAGTI...FLASSEPLFK → ESLAILFCKHIIASINILLMDA

    Note: No experimental confirmation available.

    Show »
    Length:419
    Mass (Da):47,436
    Checksum:iCEDFBC65662DBE6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241T → A in AAH97779. 1 PublicationCurated
    Sequence conflicti95 – 951V → I in AAI06204. 1 PublicationCurated
    Sequence conflicti327 – 3271A → T in AAI06204. 1 PublicationCurated
    Sequence conflicti445 – 4451H → R in AAI06204. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei398 – 48689IVECM…EPLFK → ESLAILFCKHIIASINILLM DA in isoform 2. 1 PublicationVSP_026942Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097779 mRNA. Translation: AAH97779.1.
    BC106203 mRNA. Translation: AAI06204.1.
    BC124907 mRNA. Translation: AAI24908.1.
    RefSeqiNP_001116360.1. NM_001122888.1. [Q08B22-2]
    UniGeneiXl.53984.
    Xl.59560.

    Genome annotation databases

    GeneIDi733388.
    KEGGixla:733388.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097779 mRNA. Translation: AAH97779.1 .
    BC106203 mRNA. Translation: AAI06204.1 .
    BC124907 mRNA. Translation: AAI24908.1 .
    RefSeqi NP_001116360.1. NM_001122888.1. [Q08B22-2 ]
    UniGenei Xl.53984.
    Xl.59560.

    3D structure databases

    ProteinModelPortali Q08B22.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT4. Glycosyltransferase Family 4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 733388.
    KEGGi xla:733388.

    Organism-specific databases

    CTDi 440138.
    Xenbasei XB-GENE-5934162. alg11.

    Phylogenomic databases

    HOVERGENi HBG057178.
    KOi K03844.

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Egg, Embryo and Ovary.

    Entry informationi

    Entry nameiALG11_XENLA
    AccessioniPrimary (citable) accession number: Q08B22
    Secondary accession number(s): Q3B8M7, Q4QQZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3