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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg11

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

GO - Molecular functioni

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:alg11
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5934162. alg11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956201 – 486GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseAdd BLAST486

Proteomic databases

MaxQBiQ08B22.

Structurei

3D structure databases

ProteinModelPortaliQ08B22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG057178.
KOiK03844.

Family and domain databases

InterProiView protein in InterPro
IPR031814. ALG11_N.
IPR001296. Glyco_trans_1.
PfamiView protein in Pfam
PF15924. ALG11_N. 1 hit.
PF00534. Glycos_transf_1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08B22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPMCLCGM MRLLTALFIP VLITSVGLCL IFVLLFICTR LWVQRKKKVE
60 70 80 90 100
IGKDGKKKKV VAFFHPYCNA GGGGERVLWC ALRSLQKRYK DAIYVIYTGD
110 120 130 140 150
KDASEEQILN GAAARFNIKL SHPVRFIFLE KRGLVEASCY PRFTLLGQSL
160 170 180 190 200
GSVVLGWEAL TKCVPDIYID SMGYAFTLPL FKYLGGCHVG CYVHYPTISM
210 220 230 240 250
DMLSVVRSQH ARFNNAAFIS NNPVLSRLKL IYYYLFALFY GWVGSCSDVI
260 270 280 290 300
MVNSTWTFSH ILDLWKCSDR TSIVYPPCDV QTFLEIDINQ HKENEEHSVV
310 320 330 340 350
SIGQFRPEKD HPLQIRAFAA LLEKKTAEQR AKLKLILIGG CRNDEDELRV
360 370 380 390 400
SELKKLSSEL GIPVEFKVNV PFEELKKHLS EATIGLHTMW NEHFGIGIVE
410 420 430 440 450
CMAAGTIILA HNSGGPKLDI VVPHEEQQTG FLADSVDSYA AAMDHILSLT
460 470 480
PEQRLSIRQN ARLSVGRFSD QEFEANFLAS SEPLFK
Length:486
Mass (Da):54,709
Last modified:July 24, 2007 - v2
Checksum:i36A3917D1479F946
GO
Isoform 2 (identifier: Q08B22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-486: IVECMAAGTI...FLASSEPLFK → ESLAILFCKHIIASINILLMDA

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):47,436
Checksum:iCEDFBC65662DBE6C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24T → A in AAH97779 (Ref. 1) Curated1
Sequence conflicti95V → I in AAI06204 (Ref. 1) Curated1
Sequence conflicti327A → T in AAI06204 (Ref. 1) Curated1
Sequence conflicti445H → R in AAI06204 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026942398 – 486IVECM…EPLFK → ESLAILFCKHIIASINILLM DA in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097779 mRNA. Translation: AAH97779.1.
BC106203 mRNA. Translation: AAI06204.1.
BC124907 mRNA. Translation: AAI24908.1.
RefSeqiNP_001116360.1. NM_001122888.1. [Q08B22-2]
UniGeneiXl.53984.
Xl.59560.

Genome annotation databases

GeneIDi733388.
KEGGixla:733388.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALG11_XENLA
AccessioniPrimary (citable) accession number: Q08B22
Secondary accession number(s): Q3B8M7, Q4QQZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: August 30, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families