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Q08B22

- ALG11_XENLA

UniProt

Q08B22 - ALG11_XENLA

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Protein
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Gene
alg11
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:alg11
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5934162. alg11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei230 – 25021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000295620Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ08B22.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG057178.
KOiK03844.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q08B22-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGPMCLCGM MRLLTALFIP VLITSVGLCL IFVLLFICTR LWVQRKKKVE    50
IGKDGKKKKV VAFFHPYCNA GGGGERVLWC ALRSLQKRYK DAIYVIYTGD 100
KDASEEQILN GAAARFNIKL SHPVRFIFLE KRGLVEASCY PRFTLLGQSL 150
GSVVLGWEAL TKCVPDIYID SMGYAFTLPL FKYLGGCHVG CYVHYPTISM 200
DMLSVVRSQH ARFNNAAFIS NNPVLSRLKL IYYYLFALFY GWVGSCSDVI 250
MVNSTWTFSH ILDLWKCSDR TSIVYPPCDV QTFLEIDINQ HKENEEHSVV 300
SIGQFRPEKD HPLQIRAFAA LLEKKTAEQR AKLKLILIGG CRNDEDELRV 350
SELKKLSSEL GIPVEFKVNV PFEELKKHLS EATIGLHTMW NEHFGIGIVE 400
CMAAGTIILA HNSGGPKLDI VVPHEEQQTG FLADSVDSYA AAMDHILSLT 450
PEQRLSIRQN ARLSVGRFSD QEFEANFLAS SEPLFK 486
Length:486
Mass (Da):54,709
Last modified:July 24, 2007 - v2
Checksum:i36A3917D1479F946
GO
Isoform 2 (identifier: Q08B22-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-486: IVECMAAGTI...FLASSEPLFK → ESLAILFCKHIIASINILLMDA

Note: No experimental confirmation available.

Show »
Length:419
Mass (Da):47,436
Checksum:iCEDFBC65662DBE6C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei398 – 48689IVECM…EPLFK → ESLAILFCKHIIASINILLM DA in isoform 2.
VSP_026942Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241T → A in AAH97779. 1 Publication
Sequence conflicti95 – 951V → I in AAI06204. 1 Publication
Sequence conflicti327 – 3271A → T in AAI06204. 1 Publication
Sequence conflicti445 – 4451H → R in AAI06204. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097779 mRNA. Translation: AAH97779.1.
BC106203 mRNA. Translation: AAI06204.1.
BC124907 mRNA. Translation: AAI24908.1.
RefSeqiNP_001116360.1. NM_001122888.1. [Q08B22-2]
UniGeneiXl.53984.
Xl.59560.

Genome annotation databases

GeneIDi733388.
KEGGixla:733388.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097779 mRNA. Translation: AAH97779.1 .
BC106203 mRNA. Translation: AAI06204.1 .
BC124907 mRNA. Translation: AAI24908.1 .
RefSeqi NP_001116360.1. NM_001122888.1. [Q08B22-2 ]
UniGenei Xl.53984.
Xl.59560.

3D structure databases

ProteinModelPortali Q08B22.
ModBasei Search...

Protein family/group databases

CAZyi GT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 733388.
KEGGi xla:733388.

Organism-specific databases

CTDi 440138.
Xenbasei XB-GENE-5934162. alg11.

Phylogenomic databases

HOVERGENi HBG057178.
KOi K03844.

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Egg, Embryo and Ovary.

Entry informationi

Entry nameiALG11_XENLA
AccessioniPrimary (citable) accession number: Q08B22
Secondary accession number(s): Q3B8M7, Q4QQZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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