Q08AS3 (Q08AS3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HLA-DQA1 protein EMBL AAI25046.1

Gene names

Name:

HLA-DQA1 EMBL AAI25046.1

Organism

Homo sapiens (Human) EMBL AAI25046.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS003597

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC II SAAS SAAS003597 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS014745
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q08AS3 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: B3A505BD0FE64836	FASTA	254	27,937
	10 20 30 40 50 60 MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQFTH EFDGDEEFYV 70 80 90 100 110 120 DLERKETVWK LPLFHRLRFD PQFALTNIAV LKHNLNILIK RSNSTAATNE VPEVTVFSKS 130 140 150 160 170 180 PVTLGQPNTL ICLVDNIFPP VVNITWLSNG HSVTEGVSET SFLSKSDHSF FKISYLTFLP 190 200 210 220 230 240 SADEIYDCKV EHWGLDEPLL KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVLIIR 250 GLRSVGASRH QGPL

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI25046.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC125045 mRNA. Translation: AAI25046.1.
IPI	IPI00740326.
RefSeq	XP_003120317.1. XM_003120269.1. XP_003846794.1. XM_003846746.1.
UniGene	Hs.387679. Hs.591798. Hs.706240.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100509457.
KEGG	hsa:100509457.
UCSC	uc011gjz.2. human.
Organism-specific databases
PharmGKB	PA35066.
Phylogenomic databases
HOVERGEN	HBG006862.
KO	K06752.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR001003. MHC_II_a_N. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00993. MHC_II_alpha. 1 hit. [Graphical view]
SMART	SM00407. IGc1. 1 hit. SM00920. MHC_II_alpha. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-DQA1. human.
NextBio	34054873.

Entry information

Entry name

Q08AS3_HUMAN

Accession

Primary (citable) accession number: Q08AS3

Entry history

Integrated into UniProtKB/TrEMBL:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.