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Protein

Zinc finger protein 616

Gene

ZNF616

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri185 – 207C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri717 – 739C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 767C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 616
Gene namesi
Name:ZNF616
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000204611.6
HGNCiHGNC:28062 ZNF616
neXtProtiNX_Q08AN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204611
PharmGKBiPA134978923

Polymorphism and mutation databases

BioMutaiZNF616
DMDMi257050983

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804241 – 781Zinc finger protein 616Add BLAST781

Proteomic databases

EPDiQ08AN1
MaxQBiQ08AN1
PaxDbiQ08AN1
PeptideAtlasiQ08AN1
PRIDEiQ08AN1

PTM databases

iPTMnetiQ08AN1
PhosphoSitePlusiQ08AN1

Expressioni

Gene expression databases

BgeeiENSG00000204611
CleanExiHS_ZNF616
ExpressionAtlasiQ08AN1 baseline and differential
GenevisibleiQ08AN1 HS

Organism-specific databases

HPAiHPA062639
HPA071539

Interactioni

Protein-protein interaction databases

BioGridi124691, 7 interactors
IntActiQ08AN1, 4 interactors
STRINGi9606.ENSP00000471000

Structurei

3D structure databases

ProteinModelPortaliQ08AN1
SMRiQ08AN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 84KRABPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri185 – 207C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri717 – 739C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 767C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140787
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ08AN1
KOiK09228
OMAiVHQVIHA
OrthoDBiEOG091G02KC
PhylomeDBiQ08AN1
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 21 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 21 hits
PS50157 ZINC_FINGER_C2H2_2, 21 hits

Sequencei

Sequence statusi: Complete.

Q08AN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQGHLTFK DVAIEFSQEE WKCLEPVQKA LYKDVMLENY RNLVFLGISP
60 70 80 90 100
KCVIKELPPT ENSNTGERFQ TVALERHQSY DIENLYFREI QKHLHDLEFQ
110 120 130 140 150
WKDGETNDKE VPVPHENNLT GKRDQHSQGD VENNHIENQL TSNFESRLAE
160 170 180 190 200
LQKVQTEGRL YECNETEKTG NNGCLVSPHI REKTYVCNEC GKAFKASSSL
210 220 230 240 250
INHQRIHTTE KPYKCNECGK AFHRASLLTV HKVVHTRGKS YQCDVCGKIF
260 270 280 290 300
RKNSYFVRHQ RSHTGQKPYI CNECGKSFSK SSHLAVHQRI HTGEKPYKCN
310 320 330 340 350
LCGKSFSQRV HLRLHQTVHT GERPFKCNEC GKTFKRSSNL TVHQVIHAGK
360 370 380 390 400
KPYKCDVCGK AFRHRSNLVC HRRIHSGEKQ YKCNECGKVF SKRSSLAVHR
410 420 430 440 450
RIHTVEKPCK CNECGKVFSK RSSLAVHQRI HTGQKTYKCN KCGKVYSKHS
460 470 480 490 500
HLAVHWRIHT GEKAYKCNEC GKVFSIHSRL AAHQRIHTGE KPYKCNECGK
510 520 530 540 550
VFSQHSRLAV HRRIHTGEKP YKCKECGKVF SDRSAFARHR RIHTGEKPYK
560 570 580 590 600
CKECGKVFSQ CSRLTVHRRI HSGEKPYKCN ECGKVYSQYS HLVGHRRVHT
610 620 630 640 650
GEKPYKCHEC GKAFNQGSTL NRHQRIHTGE KPYKCNQCGN SFSQRVHLRL
660 670 680 690 700
HQTVHTGDRP YKCNECGKTF KRSSNLTAHQ IIHAGKKPYK CDECGKVFRH
710 720 730 740 750
SSHLVSHQRI HTGEKRYKCI ECGKAFGRLF SLSKHQRIHS GKKPYKCNEC
760 770 780
GKSFICRSGL TKHRIRHTGE SLTTKLNVTR P
Length:781
Mass (Da):90,273
Last modified:September 1, 2009 - v2
Checksum:i487A86A65B70CE10
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06196050P → S2 PublicationsCorresponds to variant dbSNP:rs35582075Ensembl.1
Natural variantiVAR_031149451H → R. Corresponds to variant dbSNP:rs3764537Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092266 mRNA Translation: BAG52513.1
BC033199 mRNA Translation: AAH33199.1
BC125099 mRNA Translation: AAI25100.1
AL832969 mRNA Translation: CAH56353.1
CCDSiCCDS33090.1
RefSeqiNP_848618.2, NM_178523.4
UniGeneiHs.645225
Hs.731969

Genome annotation databases

EnsembliENST00000600228; ENSP00000471000; ENSG00000204611
GeneIDi90317
KEGGihsa:90317
UCSCiuc002pym.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN616_HUMAN
AccessioniPrimary (citable) accession number: Q08AN1
Secondary accession number(s): B3KRV1, Q0P658, Q658V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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