Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 616

Gene

ZNF616

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 20723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri689 – 71123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri717 – 73923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri745 – 76723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 616
Gene namesi
Name:ZNF616
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28062. ZNF616.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978923.

Polymorphism and mutation databases

BioMutaiZNF616.
DMDMi257050983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 781781Zinc finger protein 616PRO_0000280424Add
BLAST

Proteomic databases

EPDiQ08AN1.
MaxQBiQ08AN1.
PaxDbiQ08AN1.
PRIDEiQ08AN1.

PTM databases

iPTMnetiQ08AN1.
PhosphoSiteiQ08AN1.

Expressioni

Gene expression databases

BgeeiQ08AN1.
CleanExiHS_ZNF616.
ExpressionAtlasiQ08AN1. baseline and differential.
GenevisibleiQ08AN1. HS.

Interactioni

Protein-protein interaction databases

BioGridi124691. 6 interactions.
IntActiQ08AN1. 4 interactions.
STRINGi9606.ENSP00000471000.

Structurei

3D structure databases

ProteinModelPortaliQ08AN1.
SMRiQ08AN1. Positions 7-47, 148-770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8478KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 21 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 20723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri689 – 71123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri717 – 73923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri745 – 76723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08AN1.
KOiK09228.
OMAiVHQVIHA.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ08AN1.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08AN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQGHLTFK DVAIEFSQEE WKCLEPVQKA LYKDVMLENY RNLVFLGISP
60 70 80 90 100
KCVIKELPPT ENSNTGERFQ TVALERHQSY DIENLYFREI QKHLHDLEFQ
110 120 130 140 150
WKDGETNDKE VPVPHENNLT GKRDQHSQGD VENNHIENQL TSNFESRLAE
160 170 180 190 200
LQKVQTEGRL YECNETEKTG NNGCLVSPHI REKTYVCNEC GKAFKASSSL
210 220 230 240 250
INHQRIHTTE KPYKCNECGK AFHRASLLTV HKVVHTRGKS YQCDVCGKIF
260 270 280 290 300
RKNSYFVRHQ RSHTGQKPYI CNECGKSFSK SSHLAVHQRI HTGEKPYKCN
310 320 330 340 350
LCGKSFSQRV HLRLHQTVHT GERPFKCNEC GKTFKRSSNL TVHQVIHAGK
360 370 380 390 400
KPYKCDVCGK AFRHRSNLVC HRRIHSGEKQ YKCNECGKVF SKRSSLAVHR
410 420 430 440 450
RIHTVEKPCK CNECGKVFSK RSSLAVHQRI HTGQKTYKCN KCGKVYSKHS
460 470 480 490 500
HLAVHWRIHT GEKAYKCNEC GKVFSIHSRL AAHQRIHTGE KPYKCNECGK
510 520 530 540 550
VFSQHSRLAV HRRIHTGEKP YKCKECGKVF SDRSAFARHR RIHTGEKPYK
560 570 580 590 600
CKECGKVFSQ CSRLTVHRRI HSGEKPYKCN ECGKVYSQYS HLVGHRRVHT
610 620 630 640 650
GEKPYKCHEC GKAFNQGSTL NRHQRIHTGE KPYKCNQCGN SFSQRVHLRL
660 670 680 690 700
HQTVHTGDRP YKCNECGKTF KRSSNLTAHQ IIHAGKKPYK CDECGKVFRH
710 720 730 740 750
SSHLVSHQRI HTGEKRYKCI ECGKAFGRLF SLSKHQRIHS GKKPYKCNEC
760 770 780
GKSFICRSGL TKHRIRHTGE SLTTKLNVTR P
Length:781
Mass (Da):90,273
Last modified:September 1, 2009 - v2
Checksum:i487A86A65B70CE10
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501P → S.2 Publications
Corresponds to variant rs35582075 [ dbSNP | Ensembl ].
VAR_061960
Natural varianti451 – 4511H → R.
Corresponds to variant rs3764537 [ dbSNP | Ensembl ].
VAR_031149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092266 mRNA. Translation: BAG52513.1.
BC033199 mRNA. Translation: AAH33199.1.
BC125099 mRNA. Translation: AAI25100.1.
AL832969 mRNA. Translation: CAH56353.1.
CCDSiCCDS33090.1.
RefSeqiNP_848618.2. NM_178523.3.
UniGeneiHs.645225.
Hs.731969.

Genome annotation databases

EnsembliENST00000600228; ENSP00000471000; ENSG00000204611.
GeneIDi90317.
KEGGihsa:90317.
UCSCiuc002pym.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092266 mRNA. Translation: BAG52513.1.
BC033199 mRNA. Translation: AAH33199.1.
BC125099 mRNA. Translation: AAI25100.1.
AL832969 mRNA. Translation: CAH56353.1.
CCDSiCCDS33090.1.
RefSeqiNP_848618.2. NM_178523.3.
UniGeneiHs.645225.
Hs.731969.

3D structure databases

ProteinModelPortaliQ08AN1.
SMRiQ08AN1. Positions 7-47, 148-770.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124691. 6 interactions.
IntActiQ08AN1. 4 interactions.
STRINGi9606.ENSP00000471000.

PTM databases

iPTMnetiQ08AN1.
PhosphoSiteiQ08AN1.

Polymorphism and mutation databases

BioMutaiZNF616.
DMDMi257050983.

Proteomic databases

EPDiQ08AN1.
MaxQBiQ08AN1.
PaxDbiQ08AN1.
PRIDEiQ08AN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000600228; ENSP00000471000; ENSG00000204611.
GeneIDi90317.
KEGGihsa:90317.
UCSCiuc002pym.4. human.

Organism-specific databases

CTDi90317.
GeneCardsiZNF616.
HGNCiHGNC:28062. ZNF616.
neXtProtiNX_Q08AN1.
PharmGKBiPA134978923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08AN1.
KOiK09228.
OMAiVHQVIHA.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ08AN1.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii90317.
NextBioi76652.
PROiQ08AN1.

Gene expression databases

BgeeiQ08AN1.
CleanExiHS_ZNF616.
ExpressionAtlasiQ08AN1. baseline and differential.
GenevisibleiQ08AN1. HS.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-50.
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-780, VARIANT SER-50.
    Tissue: Stomach.

Entry informationi

Entry nameiZN616_HUMAN
AccessioniPrimary (citable) accession number: Q08AN1
Secondary accession number(s): B3KRV1, Q0P658, Q658V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 1, 2009
Last modified: May 11, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.