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Protein
Submitted name:

SH3 domain containing ring finger 2

Gene

SH3RF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 domain containing ring finger 2Imported
Gene namesi
Name:SH3RF2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944983.

PTM / Processingi

Proteomic databases

PaxDbiQ08AM8.
PRIDEiQ08AM8.

Expressioni

Gene expression databases

GenevisibleiQ08AM8. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-10225873,EBI-10187270
BANPQ8N9N53EBI-10225873,EBI-744695
GOLGA2Q083793EBI-10225873,EBI-618309
HOMEZQ8IX15-33EBI-10225873,EBI-10172004
LZTS2Q9BRK43EBI-10225873,EBI-741037
MTUS2Q5JR593EBI-10225873,EBI-742948
RBPMSQ930623EBI-10225873,EBI-740322
SPERTQ8NA613EBI-10225873,EBI-741724

Protein-protein interaction databases

IntActiQ08AM8. 8 interactions.
STRINGi9606.ENSP00000352028.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 5342RING-typeInterPro annotationAdd
BLAST
Domaini125 – 18460SH3InterPro annotationAdd
BLAST
Domaini187 – 25266SH3InterPro annotationAdd
BLAST
Domaini380 – 44162SH3InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 3 SH3 domains.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation, Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITG6. Eukaryota.
ENOG410XS5R. LUCA.
HOGENOMiHOG000060125.
HOVERGENiHBG082418.
KOiK12171.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08AM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRV FKAHKELRCP
60 70 80 90 100
ECRTPVFSNI EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGTMTLQDGR
110 120 130 140 150
KSRTNPRRLQ ASPFRLVPNV RIHMDGVPRA KALCNYRGQN PGDLRFNKGD
160 170 180 190 200
IILLRRQLDE NWYQGEINGI SGNFPASSVE VIKQLPQPPP LCRALYNFDL
210 220 230 240 250
RGKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDKVG IFPILFVEPN
260 270 280 290 300
LTARHLLEKN KGRQSSRTKN LSLVSSSSRG NTSTLRRGPG SRRKVPGQFS
310 320 330 340 350
ITTALNTLNR MVHSPSGRHM VEISTPVLIS SSNPSVITQP MEKADVPSSC
360 370 380 390 400
VGQVSTYHPA PVSPGHSTAV VSLPGSQQHL SANMFVALHS YSAHGPDELD
410 420 430 440 450
LQKGEGVRVL GKCQDGWLRG VSLVTGRVGI FPNNYVIPIF RKTSSFPDSR
460 470 480 490 500
SPGLYTTWTL STSSVSSQGS ISEGDPRQSR PFKSVFVPTA IVNPVRSTAG
510 520 530 540 550
PGTLGQGSLR KGRSSMRKNG SLQRPLQSGI PTLVVGSLRR SPTMVLRPQQ
560 570 580 590 600
FQFYQPQGIP SSPSAVVVEM GSKPALTGEP AFTCISRGSE ARIHSAASSL
610 620 630 640 650
IMEDKEIPIK SEPLPKPPAS APPSILVKPE NSRNGIEKQV KTVRFQNYSP
660 670 680 690 700
PPTKHYTSHP TSGKPEQPAT LKASQPEAAS LGPEMTVLFA HRSGCHSGQQ
710 720
TDLRRKSALG KATTLVSTAS GTQTVFPSK
Length:729
Mass (Da):79,324
Last modified:October 31, 2006 - v1
Checksum:i8EE48B18141DE913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125107 mRNA. Translation: AAI25108.1.
RefSeqiNP_689763.3. NM_152550.3.
UniGeneiHs.443728.

Genome annotation databases

GeneIDi153769.
KEGGihsa:153769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125107 mRNA. Translation: AAI25108.1.
RefSeqiNP_689763.3. NM_152550.3.
UniGeneiHs.443728.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ08AM8. 8 interactions.
STRINGi9606.ENSP00000352028.

Proteomic databases

PaxDbiQ08AM8.
PRIDEiQ08AM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi153769.
KEGGihsa:153769.

Organism-specific databases

CTDi153769.
PharmGKBiPA134944983.

Phylogenomic databases

eggNOGiENOG410ITG6. Eukaryota.
ENOG410XS5R. LUCA.
HOGENOMiHOG000060125.
HOVERGENiHBG082418.
KOiK12171.

Miscellaneous databases

ChiTaRSiSH3RF2. human.
GenomeRNAii153769.

Gene expression databases

GenevisibleiQ08AM8. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiQ08AM8_HUMAN
AccessioniPrimary (citable) accession number: Q08AM8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.