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Q08AM6

- VAC14_HUMAN

UniProt

Q08AM6 - VAC14_HUMAN

Protein

Protein VAC14 homolog

Gene

VAC14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 5-phosphate (PtdIns5P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: UniProtKB

    GO - Biological processi

    1. phosphatidylinositol biosynthetic process Source: Reactome
    2. phospholipid metabolic process Source: Reactome
    3. regulation of lipid kinase activity Source: InterPro
    4. signal transduction Source: UniProtKB
    5. small molecule metabolic process Source: Reactome
    6. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000103043-MONOMER.
    ReactomeiREACT_120756. Synthesis of PIPs at the early endosome membrane.
    REACT_120836. Synthesis of PIPs at the Golgi membrane.
    REACT_120918. Synthesis of PIPs at the late endosome membrane.
    REACT_198970. Synthesis of PIPs at the Golgi membrane.
    REACT_198972. Synthesis of PIPs at the late endosome membrane.
    REACT_198975. Synthesis of PIPs at the early endosome membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein VAC14 homolog
    Alternative name(s):
    Tax1-binding protein 2
    Gene namesi
    Name:VAC14
    Synonyms:TAX1BP2, TRX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25507. VAC14.

    Subcellular locationi

    Endosome membrane 2 Publications. Microsome membrane By similarity
    Note: Mainly associated with membranes of the late endocytic pathway.

    GO - Cellular componenti

    1. early endosome membrane Source: Reactome
    2. endoplasmic reticulum Source: UniProtKB-KW
    3. endosome membrane Source: UniProtKB
    4. Golgi membrane Source: Reactome
    5. late endosome membrane Source: Reactome
    6. PAS complex Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum, Endosome, Membrane, Microsome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi773 – 7731G → A: Reduces interaction with NOS1. 1 Publication
    Mutagenesisi774 – 7741D → A: Reduces interaction with NOS1. 1 Publication
    Mutagenesisi776 – 7761L → A: Reduces interaction with NOS1. 1 Publication
    Mutagenesisi777 – 7771D → A: Abolishes interaction with NOS1. 1 Publication
    Mutagenesisi780 – 7823VVL → AAA: Reduces interaction with NOS1.
    Mutagenesisi782 – 7821L → G: Reduces interaction with NOS1. 1 Publication

    Organism-specific databases

    PharmGKBiPA142670633.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 782782Protein VAC14 homologPRO_0000300485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei11 – 111Phosphothreonine1 Publication
    Modified residuei499 – 4991Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ08AM6.
    PaxDbiQ08AM6.
    PRIDEiQ08AM6.

    PTM databases

    PhosphoSiteiQ08AM6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ08AM6.
    BgeeiQ08AM6.
    CleanExiHS_VAC14.
    GenevestigatoriQ08AM6.

    Organism-specific databases

    HPAiHPA027766.

    Interactioni

    Subunit structurei

    Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Interacts with NOS1. Interacts with HTLV-1 Tax.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NOS1P294755EBI-2107455,EBI-7164065

    Protein-protein interaction databases

    BioGridi120822. 11 interactions.
    IntActiQ08AM6. 5 interactions.
    MINTiMINT-3997917.
    STRINGi9606.ENSP00000261776.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08AM6.
    SMRiQ08AM6. Positions 644-702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati5 – 4238HEAT 1Add
    BLAST
    Repeati89 – 12638HEAT 2Add
    BLAST
    Repeati171 – 20838HEAT 3Add
    BLAST
    Repeati212 – 24938HEAT 4Add
    BLAST
    Repeati438 – 47538HEAT 5Add
    BLAST
    Repeati560 – 59839HEAT 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni773 – 7775Mediates interaction with the PDZ domain of NOS1

    Domaini

    The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.1 Publication

    Sequence similaritiesi

    Belongs to the VAC14 family.Curated
    Contains 6 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG287585.
    HOVERGENiHBG104397.
    InParanoidiQ08AM6.
    KOiK15305.
    OMAiFKCLYGL.
    OrthoDBiEOG7QNVM5.
    PhylomeDBiQ08AM6.
    TreeFamiTF343690.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR026825. Vac14.
    IPR021841. VAC14_Fig4p-bd.
    [Graphical view]
    PANTHERiPTHR16023. PTHR16023. 1 hit.
    PfamiPF11916. Vac14_Fig4_bd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q08AM6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPEKDFAPL TPNIVRALND KLYEKRKVAA LEIEKLVREF VAQNNTVQIK    50
    HVIQTLSQEF ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT 100
    CFNDADSRLR YYACEALYNI VKVARGAVLP HFNVLFDGLS KLAADPDPNV 150
    KSGSELLDRL LKDIVTESNK FDLVSFIPLL RERIYSNNQY ARQFIISWIL 200
    VLESVPDINL LDYLPEILDG LFQILGDNGK EIRKMCEVVL GEFLKEIKKN 250
    PSSVKFAEMA NILVIHCQTT DDLIQLTAMC WMREFIQLAG RVMLPYSSGI 300
    LTAVLPCLAY DDRKKSIKEV ANVCNQSLMK LVTPEDDELD ELRPGQRQAE 350
    PTPDDALPKQ EGTASGGPDG SCDSSFSSGI SVFTAASTER APVTLHLDGI 400
    VQVLNCHLSD TAIGMMTRIA VLKWLYHLYI KTPRKMFRHT DSLFPILLQT 450
    LSDESDEVIL KDLEVLAEIA SSPAGQTDDP GPLDGPDLQA SHSELQVPTP 500
    GRAGLLNTSG TKGLECSPST PTMNSYFYKF MINLLKRFSS ERKLLEVRGP 550
    FIIRQLCLLL NAENIFHSMA DILLREEDLK FASTMVHALN TILLTSTELF 600
    QLRNQLKDLK TLESQNLFCC LYRSWCHNPV TTVSLCFLTQ NYRHAYDLIQ 650
    KFGDLEVTVD FLAEVDKLVQ LIECPIFTYL RLQLLDVKNN PYLIKALYGL 700
    LMLLPQSSAF QLLSHRLQCV PNPELLQTED SLKAAPKSQK ADSPSIDYAE 750
    LLQHFEKVQN KHLEVRHQRS GRGDHLDRRV VL 782
    Length:782
    Mass (Da):87,973
    Last modified:October 31, 2006 - v1
    Checksum:iB39AC1F4D619570F
    GO
    Isoform 2 (identifier: Q08AM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-568: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:214
    Mass (Da):24,783
    Checksum:iE438C0F3365F70AB
    GO

    Sequence cautioni

    The sequence AAB03813.1 differs from that shown. Reason: Unknown C-terminal region.
    The sequence BAB15145.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571A → P in AAB03813. (PubMed:8611628)Curated
    Sequence conflicti263 – 2631L → P in AAB03813. (PubMed:8611628)Curated
    Sequence conflicti352 – 3521T → A in CAG33624. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 568568Missing in isoform 2. 1 PublicationVSP_056097Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025479 mRNA. Translation: BAB15145.1. Different initiation.
    AK056433 mRNA. Translation: BAG51707.1.
    AK093941 mRNA. Translation: BAG52790.1.
    AC020763 Genomic DNA. No translation available.
    AC027281 Genomic DNA. No translation available.
    BC000536 mRNA. Translation: AAH00536.2.
    BC007214 mRNA. Translation: AAH07214.2.
    BC125108 mRNA. Translation: AAI25109.1.
    BC125109 mRNA. Translation: AAI25110.1.
    U25801 mRNA. Translation: AAB03813.1. Sequence problems.
    CR457343 mRNA. Translation: CAG33624.1.
    CCDSiCCDS10896.1.
    PIRiS68091.
    RefSeqiNP_060522.3. NM_018052.3.
    UniGeneiHs.445061.

    Genome annotation databases

    EnsembliENST00000261776; ENSP00000261776; ENSG00000103043.
    ENST00000536184; ENSP00000439284; ENSG00000103043.
    GeneIDi55697.
    KEGGihsa:55697.
    UCSCiuc002ezm.3. human.

    Polymorphism databases

    DMDMi121940040.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025479 mRNA. Translation: BAB15145.1 . Different initiation.
    AK056433 mRNA. Translation: BAG51707.1 .
    AK093941 mRNA. Translation: BAG52790.1 .
    AC020763 Genomic DNA. No translation available.
    AC027281 Genomic DNA. No translation available.
    BC000536 mRNA. Translation: AAH00536.2 .
    BC007214 mRNA. Translation: AAH07214.2 .
    BC125108 mRNA. Translation: AAI25109.1 .
    BC125109 mRNA. Translation: AAI25110.1 .
    U25801 mRNA. Translation: AAB03813.1 . Sequence problems.
    CR457343 mRNA. Translation: CAG33624.1 .
    CCDSi CCDS10896.1.
    PIRi S68091.
    RefSeqi NP_060522.3. NM_018052.3.
    UniGenei Hs.445061.

    3D structure databases

    ProteinModelPortali Q08AM6.
    SMRi Q08AM6. Positions 644-702.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120822. 11 interactions.
    IntActi Q08AM6. 5 interactions.
    MINTi MINT-3997917.
    STRINGi 9606.ENSP00000261776.

    PTM databases

    PhosphoSitei Q08AM6.

    Polymorphism databases

    DMDMi 121940040.

    Proteomic databases

    MaxQBi Q08AM6.
    PaxDbi Q08AM6.
    PRIDEi Q08AM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261776 ; ENSP00000261776 ; ENSG00000103043 .
    ENST00000536184 ; ENSP00000439284 ; ENSG00000103043 .
    GeneIDi 55697.
    KEGGi hsa:55697.
    UCSCi uc002ezm.3. human.

    Organism-specific databases

    CTDi 55697.
    GeneCardsi GC16M070721.
    HGNCi HGNC:25507. VAC14.
    HPAi HPA027766.
    MIMi 604632. gene.
    neXtProti NX_Q08AM6.
    PharmGKBi PA142670633.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287585.
    HOVERGENi HBG104397.
    InParanoidi Q08AM6.
    KOi K15305.
    OMAi FKCLYGL.
    OrthoDBi EOG7QNVM5.
    PhylomeDBi Q08AM6.
    TreeFami TF343690.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000103043-MONOMER.
    Reactomei REACT_120756. Synthesis of PIPs at the early endosome membrane.
    REACT_120836. Synthesis of PIPs at the Golgi membrane.
    REACT_120918. Synthesis of PIPs at the late endosome membrane.
    REACT_198970. Synthesis of PIPs at the Golgi membrane.
    REACT_198972. Synthesis of PIPs at the late endosome membrane.
    REACT_198975. Synthesis of PIPs at the early endosome membrane.

    Miscellaneous databases

    ChiTaRSi VAC14. human.
    GeneWikii VAC14.
    GenomeRNAii 55697.
    NextBioi 60525.
    PROi Q08AM6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08AM6.
    Bgeei Q08AM6.
    CleanExi HS_VAC14.
    Genevestigatori Q08AM6.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR026825. Vac14.
    IPR021841. VAC14_Fig4p-bd.
    [Graphical view ]
    PANTHERi PTHR16023. PTHR16023. 1 hit.
    Pfami PF11916. Vac14_Fig4_bd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Trachea.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Lung.
    4. "Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein."
      Mireskandari A., Reid R.L., Kashanchi F., Dittmer J., Li W.B., Brady J.N.
      Biochim. Biophys. Acta 1306:9-13(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-366 (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH HTLV-I TAX.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-782 (ISOFORM 1).
    6. "A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity."
      Sbrissa D., Ikonomov O.C., Strakova J., Dondapati R., Mlak K., Deeb R., Silver R., Shisheva A.
      Mol. Cell. Biol. 24:10437-10447(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif."
      Lemaire J.F., McPherson P.S.
      FEBS Lett. 580:6948-6954(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NOS1, MUTAGENESIS OF GLY-773; ASP-774; LEU-776; ASP-777; 780-VAL--LEU-782 AND LEU-782.
    8. "Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex."
      Sbrissa D., Ikonomov O.C., Fu Z., Ijuin T., Gruenberg J., Takenawa T., Shisheva A.
      J. Biol. Chem. 282:23878-23891(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX.
    9. "ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality."
      Sbrissa D., Ikonomov O.C., Fenner H., Shisheva A.
      J. Mol. Biol. 384:766-779(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX, DOMAIN.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11 AND THR-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVAC14_HUMAN
    AccessioniPrimary (citable) accession number: Q08AM6
    Secondary accession number(s): B3KPJ5
    , B3KSM8, Q13174, Q6IA12, Q7L4Y1, Q9BW96, Q9H6V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3