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Reviewed, UniProtKB/Swiss-Prot Q08AM6 (VAC14_HUMAN)

Last modified June 16, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein VAC14 homolog
Alternative name(s):
    Tax1-binding protein 2
Gene names
Name: VAC14
Synonyms: TAX1BP2, TRX
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length782 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Tissue specificity

Ubiquitously expressed. Ref.3

Induction

Interacts with HTLV-1 Tax.

Sequence similarities

Belongs to the VAC14 family.

Contains 6 HEAT repeats.

Sequence caution

The sequence AAB03813.1 differs from that shown. Reason: Miscellaneous discrepancy. Unknown C-terminal region.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EIF4A2Q142401EBI-2107455,EBI-73473

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 782782Protein VAC14 homolog
PRO_0000300485

Regions

Repeat5 – 4238HEAT 1
Repeat89 – 12638HEAT 2
Repeat171 – 20838HEAT 3
Repeat212 – 24938HEAT 4
Repeat438 – 47538HEAT 5
Repeat560 – 59839HEAT 6

Amino acid modifications

Modified residue111Phosphothreonine Ref.5
Modified residue4991Phosphothreonine Ref.5

Experimental info

Sequence conflict2571A → P in AAB03813. Ref.3
Sequence conflict2631L → P in AAB03813. Ref.3
Sequence conflict3521T → A in CAG33624. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q08AM6-1 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: B39AC1F4D619570F

FASTA78287,973
        10         20         30         40         50         60 
MNPEKDFAPL TPNIVRALND KLYEKRKVAA LEIEKLVREF VAQNNTVQIK HVIQTLSQEF 

        70         80         90        100        110        120 
ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT CFNDADSRLR YYACEALYNI 

       130        140        150        160        170        180 
VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESNK FDLVSFIPLL 

       190        200        210        220        230        240 
RERIYSNNQY ARQFIISWIL VLESVPDINL LDYLPEILDG LFQILGDNGK EIRKMCEVVL 

       250        260        270        280        290        300 
GEFLKEIKKN PSSVKFAEMA NILVIHCQTT DDLIQLTAMC WMREFIQLAG RVMLPYSSGI 

       310        320        330        340        350        360 
LTAVLPCLAY DDRKKSIKEV ANVCNQSLMK LVTPEDDELD ELRPGQRQAE PTPDDALPKQ 

       370        380        390        400        410        420 
EGTASGGPDG SCDSSFSSGI SVFTAASTER APVTLHLDGI VQVLNCHLSD TAIGMMTRIA 

       430        440        450        460        470        480 
VLKWLYHLYI KTPRKMFRHT DSLFPILLQT LSDESDEVIL KDLEVLAEIA SSPAGQTDDP 

       490        500        510        520        530        540 
GPLDGPDLQA SHSELQVPTP GRAGLLNTSG TKGLECSPST PTMNSYFYKF MINLLKRFSS 

       550        560        570        580        590        600 
ERKLLEVRGP FIIRQLCLLL NAENIFHSMA DILLREEDLK FASTMVHALN TILLTSTELF 

       610        620        630        640        650        660 
QLRNQLKDLK TLESQNLFCC LYRSWCHNPV TTVSLCFLTQ NYRHAYDLIQ KFGDLEVTVD 

       670        680        690        700        710        720 
FLAEVDKLVQ LIECPIFTYL RLQLLDVKNN PYLIKALYGL LMLLPQSSAF QLLSHRLQCV 

       730        740        750        760        770        780 
PNPELLQTED SLKAAPKSQK ADSPSIDYAE LLQHFEKVQN KHLEVRHQRS GRGDHLDRRV 


VL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lung.
[3]"Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein."
Mireskandari A., Reid R.L., Kashanchi F., Dittmer J., Li W.B., Brady J.N.
Biochim. Biophys. Acta 1306:9-13(1996) [PubMed: 8611628] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-366, TISSUE SPECIFICITY, INTERACTION WITH HTLV-I TAX.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-782.
[5]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11 AND THR-499, MASS SPECTROMETRY.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AK025479 mRNA. Translation: BAB15145.1. Different initiation.
AK056433 mRNA. Translation: BAG51707.1.
BC000536 mRNA. Translation: AAH00536.2.
BC007214 mRNA. Translation: AAH07214.2.
BC125108 mRNA. Translation: AAI25109.1.
BC125109 mRNA. Translation: AAI25110.1.
U25801 mRNA. Translation: AAB03813.1. Sequence problems.
CR457343 mRNA. Translation: CAG33624.1.
IPIIPI00025160.
PIRS68091.
RefSeqNP_060522.3.
UniGeneHs.445061

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ08AM6. 1 interaction.

PTM databases

PhosphoSiteQ08AM6.

Proteomic databases

PRIDEQ08AM6.

Genome annotation databases

EnsemblENSG00000103043. Homo sapiens. [Contig view]
GeneID55697.
KEGGhsa:55697.

Organism-specific databases

GeneCardsGC16M069280.
HGNCHGNC:25507. VAC14.
MIM604632. gene.
PharmGKBPA142670633.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ08AM6.
OMAQ08AM6. LQTEDSL.

Gene expression databases

ArrayExpressQ08AM6.
BgeeQ08AM6.
CleanExHS_VAC14.

Family and domain databases

InterProIPR011989. ARM-like.
IPR000357. HEAT.
[Graphical view]
Gene3DG3DSA:1.25.10.10. ARM-like. 1 hit.
PfamPF02985. HEAT. 1 hit.
[Graphical view]
PROSITEPS50077. HEAT_REPEAT. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio60525.
SOURCESearch...

Entry information

Entry nameVAC14_HUMAN
AccessionPrimary (citable) accession number: Q08AM6
Secondary accession number(s): B3KPJ5 expand/collapse secondary AC list , Q13174, Q6IA12, Q7L4Y1, Q9BW96, Q9H6V6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 31, 2006
Last modified: June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents