Reviewed, UniProtKB/Swiss-Prot Q08AM6 (VAC14_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein VAC14 homolog
Alternative name(s):
    Tax1-binding protein 2

Gene names

Name:	VAC14
Synonyms:	TAX1BP2, TRX

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Ubiquitously expressed. Ref.3
Induction	Interacts with HTLV-1 Tax.
Sequence similarities	Belongs to the VAC14 family. Contains 6 HEAT repeats.
Sequence caution	The sequence AAB03813.1 differs from that shown. Reason: Miscellaneous discrepancy. Unknown C-terminal region.

Ontologies

Keywords
Biological process	Host-virus interaction
Domain	Repeat
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Ref.3 Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct receptor activity Ref.3 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF4A2	Q14240	1	EBI-2107455,EBI-73473

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 782	782	Protein VAC14 homolog		PRO_0000300485
Regions
	Repeat	5 – 42	38	HEAT 1
	Repeat	89 – 126	38	HEAT 2
	Repeat	171 – 208	38	HEAT 3
	Repeat	212 – 249	38	HEAT 4
	Repeat	438 – 475	38	HEAT 5
	Repeat	560 – 598	39	HEAT 6
Amino acid modifications
	Modified residue	11	1	Phosphothreonine Ref.5
	Modified residue	499	1	Phosphothreonine Ref.5
Experimental info
	Sequence conflict	257	1	A → P in AAB03813. Ref.3
	Sequence conflict	263	1	L → P in AAB03813. Ref.3
	Sequence conflict	352	1	T → A in CAG33624. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q08AM6-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: B39AC1F4D619570F	FASTA	782	87,973
	10 20 30 40 50 60 MNPEKDFAPL TPNIVRALND KLYEKRKVAA LEIEKLVREF VAQNNTVQIK HVIQTLSQEF 70 80 90 100 110 120 ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT CFNDADSRLR YYACEALYNI 130 140 150 160 170 180 VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESNK FDLVSFIPLL 190 200 210 220 230 240 RERIYSNNQY ARQFIISWIL VLESVPDINL LDYLPEILDG LFQILGDNGK EIRKMCEVVL 250 260 270 280 290 300 GEFLKEIKKN PSSVKFAEMA NILVIHCQTT DDLIQLTAMC WMREFIQLAG RVMLPYSSGI 310 320 330 340 350 360 LTAVLPCLAY DDRKKSIKEV ANVCNQSLMK LVTPEDDELD ELRPGQRQAE PTPDDALPKQ 370 380 390 400 410 420 EGTASGGPDG SCDSSFSSGI SVFTAASTER APVTLHLDGI VQVLNCHLSD TAIGMMTRIA 430 440 450 460 470 480 VLKWLYHLYI KTPRKMFRHT DSLFPILLQT LSDESDEVIL KDLEVLAEIA SSPAGQTDDP 490 500 510 520 530 540 GPLDGPDLQA SHSELQVPTP GRAGLLNTSG TKGLECSPST PTMNSYFYKF MINLLKRFSS 550 560 570 580 590 600 ERKLLEVRGP FIIRQLCLLL NAENIFHSMA DILLREEDLK FASTMVHALN TILLTSTELF 610 620 630 640 650 660 QLRNQLKDLK TLESQNLFCC LYRSWCHNPV TTVSLCFLTQ NYRHAYDLIQ KFGDLEVTVD 670 680 690 700 710 720 FLAEVDKLVQ LIECPIFTYL RLQLLDVKNN PYLIKALYGL LMLLPQSSAF QLLSHRLQCV 730 740 750 760 770 780 PNPELLQTED SLKAAPKSQK ADSPSIDYAE LLQHFEKVQN KHLEVRHQRS GRGDHLDRRV VL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[3]	"Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein." Mireskandari A., Reid R.L., Kashanchi F., Dittmer J., Li W.B., Brady J.N. Biochim. Biophys. Acta 1306:9-13(1996) [PubMed: 8611628] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-366, TISSUE SPECIFICITY, INTERACTION WITH HTLV-I TAX.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-782.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11 AND THR-499, MASS SPECTROMETRY.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK025479 mRNA. Translation: BAB15145.1. Different initiation. AK056433 mRNA. Translation: BAG51707.1. BC000536 mRNA. Translation: AAH00536.2. BC007214 mRNA. Translation: AAH07214.2. BC125108 mRNA. Translation: AAI25109.1. BC125109 mRNA. Translation: AAI25110.1. U25801 mRNA. Translation: AAB03813.1. Sequence problems. CR457343 mRNA. Translation: CAG33624.1.
IPI	IPI00025160.
PIR	S68091.
RefSeq	NP_060522.3.
UniGene	Hs.445061
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q08AM6. 1 interaction.
PTM databases
PhosphoSite	Q08AM6.
Proteomic databases
PRIDE	Q08AM6.
Genome annotation databases
Ensembl	ENSG00000103043. Homo sapiens. [Contig view]
GeneID	55697.
KEGG	hsa:55697.
Organism-specific databases
GeneCards	GC16M069280.
HGNC	HGNC:25507. VAC14.
MIM	604632. gene.
PharmGKB	PA142670633.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q08AM6.
OMA	Q08AM6. LQTEDSL.
Gene expression databases
ArrayExpress	Q08AM6.
Bgee	Q08AM6.
CleanEx	HS_VAC14.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR000357. HEAT. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
Pfam	PF02985. HEAT. 1 hit. [Graphical view]
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	60525.
SOURCE	Search...

Entry information

Entry name

VAC14_HUMAN

Accession

Primary (citable) accession number: Q08AM6
Secondary accession number(s): B3KPJ5 , Q13174, Q6IA12, Q7L4Y1, Q9BW96, Q9H6V6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 31, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)