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Protein

Putative sodium-coupled neutral amino acid transporter 11

Gene

SLC38A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Ion transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

TCDBi2.A.18.6.18. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 11
Alternative name(s):
Solute carrier family 38 member 11
Gene namesi
Name:SLC38A11
Synonyms:AVT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169507.9.
HGNCiHGNC:26836. SLC38A11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei241 – 263HelicalSequence analysisAdd BLAST23
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi151258.
OpenTargetsiENSG00000169507.
PharmGKBiPA162403771.

Polymorphism and mutation databases

BioMutaiSLC38A11.
DMDMi121940010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260591 – 406Putative sodium-coupled neutral amino acid transporter 11Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ08AI6.
PRIDEiQ08AI6.

PTM databases

iPTMnetiQ08AI6.
PhosphoSitePlusiQ08AI6.

Expressioni

Gene expression databases

BgeeiENSG00000169507.
CleanExiHS_SLC38A11.
ExpressionAtlasiQ08AI6. baseline and differential.
GenevisibleiQ08AI6. HS.

Organism-specific databases

HPAiHPA043432.

Interactioni

Protein-protein interaction databases

IntActiQ08AI6. 1 interactor.
STRINGi9606.ENSP00000386272.

Structurei

3D structure databases

ProteinModelPortaliQ08AI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000188354.
HOVERGENiHBG106990.
InParanoidiQ08AI6.
KOiK14997.
PhylomeDBiQ08AI6.
TreeFamiTF328787.

Family and domain databases

InterProiView protein in InterPro
IPR013057. AA_transpt_TM.
PfamiView protein in Pfam
PF01490. Aa_trans. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08AI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQAGFPLGI LLLFWVSYVT DFSLVLLIKG GALSGTDTYQ SLVNKTFGFP
60 70 80 90 100
GYLLLSVLQF LYPFIAMISY NIIAGDTLSK VFQRIPGVDP ENVFIGRHFI
110 120 130 140 150
IGLSTVTFTL PLSLYRNIAK LGKVSLISTG LTTLILGIVM ARAISLGPHI
160 170 180 190 200
PKTEDAWVFA KPNAIQAVGV MSFAFICHHN SFLVYSSLEE PTVAKWSRLI
210 220 230 240 250
HMSIVISVFI CIFFATCGYL TFTGFTQGDL FENYCRNDDL VTFGRFCYGV
260 270 280 290 300
TVILTYPMEC FVTREVIANV FFGGNLSSVF HIVVTVMVIT VATLVSLLID
310 320 330 340 350
CLGIVLELNG VLCATPLIFI IPSACYLKLS EEPRTHSDKI MSCVMLPIGA
360 370 380 390 400
VVMVFGFVMA ITNTQDCTHG QEMFYCFPDN FSLTNTSESH VQQTTQLSTL

NISIFQ
Length:406
Mass (Da):44,825
Last modified:October 31, 2006 - v1
Checksum:i1053D3DAAEDC8296
GO
Isoform 2 (identifier: Q08AI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-87: Missing.

Show »
Length:384
Mass (Da):42,448
Checksum:i2DD27F07E1AEB059
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039981194A → T. Corresponds to variant dbSNP:rs4564790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03252966 – 87Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097141 mRNA. Translation: BAC04962.1.
AK293998 mRNA. Translation: BAG57360.1.
AC019197 Genomic DNA. Translation: AAY14946.1.
CH471058 Genomic DNA. Translation: EAX11337.1.
BC125157 mRNA. Translation: AAI25158.1.
CCDSiCCDS2224.1. [Q08AI6-2]
CCDS56142.1. [Q08AI6-1]
RefSeqiNP_001186077.1. NM_001199148.1. [Q08AI6-1]
NP_775783.1. NM_173512.2. [Q08AI6-2]
UniGeneiHs.658702.

Genome annotation databases

EnsembliENST00000303735; ENSP00000306178; ENSG00000169507. [Q08AI6-2]
ENST00000409149; ENSP00000386272; ENSG00000169507. [Q08AI6-1]
ENST00000409662; ENSP00000386774; ENSG00000169507. [Q08AI6-1]
GeneIDi151258.
KEGGihsa:151258.
UCSCiuc002ucu.3. human. [Q08AI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS38AB_HUMAN
AccessioniPrimary (citable) accession number: Q08AI6
Secondary accession number(s): B4DF99, Q8N887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 31, 2006
Last modified: September 27, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families