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Protein

Putative sodium-coupled neutral amino acid transporter 11

Gene

SLC38A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.18. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 11
Alternative name(s):
Solute carrier family 38 member 11
Gene namesi
Name:SLC38A11
Synonyms:AVT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26836. SLC38A11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST
Transmembranei241 – 26323HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403771.

Polymorphism and mutation databases

BioMutaiSLC38A11.
DMDMi121940010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Putative sodium-coupled neutral amino acid transporter 11PRO_0000326059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ08AI6.
PRIDEiQ08AI6.

PTM databases

PhosphoSiteiQ08AI6.

Expressioni

Gene expression databases

BgeeiQ08AI6.
CleanExiHS_SLC38A11.
ExpressionAtlasiQ08AI6. baseline and differential.
GenevisibleiQ08AI6. HS.

Organism-specific databases

HPAiHPA043432.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386272.

Structurei

3D structure databases

ProteinModelPortaliQ08AI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000188354.
HOVERGENiHBG106990.
InParanoidiQ08AI6.
KOiK14997.
OrthoDBiEOG7SBNNK.
PhylomeDBiQ08AI6.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08AI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQAGFPLGI LLLFWVSYVT DFSLVLLIKG GALSGTDTYQ SLVNKTFGFP
60 70 80 90 100
GYLLLSVLQF LYPFIAMISY NIIAGDTLSK VFQRIPGVDP ENVFIGRHFI
110 120 130 140 150
IGLSTVTFTL PLSLYRNIAK LGKVSLISTG LTTLILGIVM ARAISLGPHI
160 170 180 190 200
PKTEDAWVFA KPNAIQAVGV MSFAFICHHN SFLVYSSLEE PTVAKWSRLI
210 220 230 240 250
HMSIVISVFI CIFFATCGYL TFTGFTQGDL FENYCRNDDL VTFGRFCYGV
260 270 280 290 300
TVILTYPMEC FVTREVIANV FFGGNLSSVF HIVVTVMVIT VATLVSLLID
310 320 330 340 350
CLGIVLELNG VLCATPLIFI IPSACYLKLS EEPRTHSDKI MSCVMLPIGA
360 370 380 390 400
VVMVFGFVMA ITNTQDCTHG QEMFYCFPDN FSLTNTSESH VQQTTQLSTL

NISIFQ
Length:406
Mass (Da):44,825
Last modified:October 31, 2006 - v1
Checksum:i1053D3DAAEDC8296
GO
Isoform 2 (identifier: Q08AI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-87: Missing.

Show »
Length:384
Mass (Da):42,448
Checksum:i2DD27F07E1AEB059
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941A → T.
Corresponds to variant rs4564790 [ dbSNP | Ensembl ].
VAR_039981

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 8722Missing in isoform 2. 1 PublicationVSP_032529Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097141 mRNA. Translation: BAC04962.1.
AK293998 mRNA. Translation: BAG57360.1.
AC019197 Genomic DNA. Translation: AAY14946.1.
CH471058 Genomic DNA. Translation: EAX11337.1.
BC125157 mRNA. Translation: AAI25158.1.
CCDSiCCDS2224.1. [Q08AI6-2]
CCDS56142.1. [Q08AI6-1]
RefSeqiNP_001186077.1. NM_001199148.1. [Q08AI6-1]
NP_775783.1. NM_173512.2. [Q08AI6-2]
UniGeneiHs.658702.

Genome annotation databases

EnsembliENST00000303735; ENSP00000306178; ENSG00000169507. [Q08AI6-2]
ENST00000409149; ENSP00000386272; ENSG00000169507. [Q08AI6-1]
ENST00000409662; ENSP00000386774; ENSG00000169507. [Q08AI6-1]
GeneIDi151258.
KEGGihsa:151258.
UCSCiuc002ucu.3. human. [Q08AI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097141 mRNA. Translation: BAC04962.1.
AK293998 mRNA. Translation: BAG57360.1.
AC019197 Genomic DNA. Translation: AAY14946.1.
CH471058 Genomic DNA. Translation: EAX11337.1.
BC125157 mRNA. Translation: AAI25158.1.
CCDSiCCDS2224.1. [Q08AI6-2]
CCDS56142.1. [Q08AI6-1]
RefSeqiNP_001186077.1. NM_001199148.1. [Q08AI6-1]
NP_775783.1. NM_173512.2. [Q08AI6-2]
UniGeneiHs.658702.

3D structure databases

ProteinModelPortaliQ08AI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386272.

Protein family/group databases

TCDBi2.A.18.6.18. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteiQ08AI6.

Polymorphism and mutation databases

BioMutaiSLC38A11.
DMDMi121940010.

Proteomic databases

PaxDbiQ08AI6.
PRIDEiQ08AI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303735; ENSP00000306178; ENSG00000169507. [Q08AI6-2]
ENST00000409149; ENSP00000386272; ENSG00000169507. [Q08AI6-1]
ENST00000409662; ENSP00000386774; ENSG00000169507. [Q08AI6-1]
GeneIDi151258.
KEGGihsa:151258.
UCSCiuc002ucu.3. human. [Q08AI6-1]

Organism-specific databases

CTDi151258.
GeneCardsiSLC38A11.
HGNCiHGNC:26836. SLC38A11.
HPAiHPA043432.
MIMi616526. gene.
neXtProtiNX_Q08AI6.
PharmGKBiPA162403771.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000188354.
HOVERGENiHBG106990.
InParanoidiQ08AI6.
KOiK14997.
OrthoDBiEOG7SBNNK.
PhylomeDBiQ08AI6.
TreeFamiTF328787.

Miscellaneous databases

ChiTaRSiSLC38A11. human.
GenomeRNAii151258.
NextBioi86653.
PROiQ08AI6.
SOURCEiSearch...

Gene expression databases

BgeeiQ08AI6.
CleanExiHS_SLC38A11.
ExpressionAtlasiQ08AI6. baseline and differential.
GenevisibleiQ08AI6. HS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Spleen.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiS38AB_HUMAN
AccessioniPrimary (citable) accession number: Q08AI6
Secondary accession number(s): B4DF99, Q8N887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 31, 2006
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.