Q08AG7 (MZT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitotic-spindle organizing protein 1

Alternative name(s):
Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1

Gene names

Name:	MZT1
Synonyms:	C13orf37, MOZART1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	82 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for gamma-tubulin complex recruitment to the centrosome. Ref.3
Subunit structure	Part of the gamma-tubulin complex. Interacts with TUBG1. Ref.3
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle Ref.3.
Sequence similarities	Belongs to the MOZART1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gamma-tubulin complex localization Inferred from mutant phenotype Ref.3. Source: UniProtKB
Cellular component	centrosome Inferred from direct assay Ref.3. Source: UniProtKB gamma-tubulin ring complex Inferred from direct assay Ref.3. Source: UniProtKB spindle Inferred from direct assay Ref.3. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.3. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TUBG1	P23258	2	EBI-2637198,EBI-302589

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 82	82	Mitotic-spindle organizing protein 1		PRO_0000337015
Regions
	Compositional bias	7 – 16	10	Poly-Ala
Natural variations
	Natural variant	5	1	S → G. Ref.2 Corresponds to variant rs1465896 [ dbSNP | Ensembl ].		VAR_043562

Sequences

	Sequence		Length	Mass (Da)
	Q08AG7 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: EA48466A00CF23C7	FASTA	82	8,479
	10 20 30 40 50 60 MASSSGAGAA AAAAAANLNA VRETMDVLLE ISRILNTGLD METLSICVRL CEQGINPEAL 70 80 SSVIKELRKA TEALKAAENM TS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-5.
[3]	"Systematic analysis of human protein complexes identifies chromosome segregation proteins." Hutchins J.R., Toyoda Y., Hegemann B., Poser I., Heriche J.K., Sykora M.M., Augsburg M., Hudecz O., Buschhorn B.A., Bulkescher J., Conrad C., Comartin D., Schleiffer A., Sarov M., Pozniakovsky A., Slabicki M.M., Schloissnig S., Steinmacher I. , Leuschner M., Ssykor A., Lawo S., Pelletier L., Stark H., Nasmyth K., Ellenberg J., Durbin R., Buchholz F., Mechtler K., Hyman A.A., Peters J.M. Science 328:593-599(2010) [PubMed: 20360068] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TUBG1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL356754, AL138695 Genomic DNA. Translation: CAH70226.1. AL138695, AL356754 Genomic DNA. Translation: CAH72711.1. BC125183 mRNA. Translation: AAI25184.1.
IPI	IPI00456981.
RefSeq	NP_001065243.1. NM_001071775.2.
UniGene	Hs.28465.
3D structure databases
ProteinModelPortal	Q08AG7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q08AG7. 6 interactions.
STRING	Q08AG7.
Polymorphism databases
DMDM	189037059.
Proteomic databases
PRIDE	Q08AG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377818; ENSP00000367049; ENSG00000204899.
GeneID	440145.
KEGG	hsa:440145.
UCSC	uc001viu.2. human.
Organism-specific databases
CTD	440145.
GeneCards	GC13M073283.
HGNC	HGNC:33830. MZT1.
MIM	613448. gene.
neXtProt	NX_Q08AG7.
PharmGKB	PA162378094. PA165505227.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21427.
GeneTree	ENSGT00390000005954.
HOGENOM	HBG628508.
HOVERGEN	HBG107722.
InParanoid	Q08AG7.
OMA	FEISRIL.
OrthoDB	EOG4CG09Z.
PhylomeDB	Q08AG7.
Gene expression databases
ArrayExpress	Q08AG7.
Bgee	Q08AG7.
CleanEx	HS_C13orf37.
Genevestigator	Q08AG7.
Family and domain databases
InterPro	IPR022214. DUF3743. [Graphical view]
Pfam	PF12554. MOZART1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	108990.
SOURCE	Search...

Entry information

Entry name

MZT1_HUMAN

Accession

Primary (citable) accession number: Q08AG7
Secondary accession number(s): Q5W0P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.