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Protein

Mitotic-spindle organizing protein 1

Gene

MZT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for gamma-tubulin complex recruitment to the centrosome.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic-spindle organizing protein 1
Alternative name(s):
Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1
Gene namesi
Name:MZT1
Synonyms:C13orf37, MOZART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000204899.5
HGNCiHGNC:33830 MZT1
MIMi613448 gene
neXtProtiNX_Q08AG7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204899
PharmGKBiPA165505227

Polymorphism and mutation databases

BioMutaiMZT1
DMDMi189037059

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003370152 – 82Mitotic-spindle organizing protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ08AG7
MaxQBiQ08AG7
PaxDbiQ08AG7
PeptideAtlasiQ08AG7
PRIDEiQ08AG7
TopDownProteomicsiQ08AG7

PTM databases

iPTMnetiQ08AG7
PhosphoSitePlusiQ08AG7

Expressioni

Gene expression databases

BgeeiENSG00000204899
CleanExiHS_C13orf37
GenevisibleiQ08AG7 HS

Organism-specific databases

HPAiHPA063299
HPA066715

Interactioni

Subunit structurei

Part of the gamma-tubulin complex. Interacts with TUBG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TUBG1P232583EBI-2637198,EBI-302589

GO - Molecular functioni

Protein-protein interaction databases

BioGridi136335, 40 interactors
IntActiQ08AG7, 41 interactors
STRINGi9606.ENSP00000367049

Structurei

3D structure databases

ProteinModelPortaliQ08AG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 16Poly-Ala10

Sequence similaritiesi

Belongs to the MOZART1 family.Curated

Phylogenomic databases

eggNOGiENOG410J18H Eukaryota
ENOG410XVXZ LUCA
GeneTreeiENSGT00390000005954
HOGENOMiHOG000217071
HOVERGENiHBG107722
InParanoidiQ08AG7
KOiK18633
OMAiATENMTS
OrthoDBiEOG091G17EG
PhylomeDBiQ08AG7
TreeFamiTF328444

Family and domain databases

InterProiView protein in InterPro
IPR022214 MZT1
PANTHERiPTHR28520 PTHR28520, 1 hit
PfamiView protein in Pfam
PF12554 MOZART1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08AG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGAGAA AAAAAANLNA VRETMDVLLE ISRILNTGLD METLSICVRL
60 70 80
CEQGINPEAL SSVIKELRKA TEALKAAENM TS
Length:82
Mass (Da):8,479
Last modified:May 20, 2008 - v2
Checksum:iEA48466A00CF23C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0435625S → G1 PublicationCorresponds to variant dbSNP:rs1465896Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356754 Genomic DNA No translation available.
AL138695 Genomic DNA No translation available.
BC125183 mRNA Translation: AAI25184.1
CCDSiCCDS31990.1
RefSeqiNP_001065243.1, NM_001071775.2
UniGeneiHs.28465

Genome annotation databases

EnsembliENST00000377818; ENSP00000367049; ENSG00000204899
GeneIDi440145
KEGGihsa:440145
UCSCiuc001viu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMZT1_HUMAN
AccessioniPrimary (citable) accession number: Q08AG7
Secondary accession number(s): Q5W0P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health