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Protein

Mitotic-spindle organizing protein 1

Gene

MZT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for gamma-tubulin complex recruitment to the centrosome.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32813-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic-spindle organizing protein 1
Alternative name(s):
Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1
Gene namesi
Name:MZT1
Synonyms:C13orf37, MOZART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:33830. MZT1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • equatorial microtubule organizing center Source: GO_Central
  • gamma-tubulin ring complex Source: UniProtKB
  • interphase microtubule organizing center Source: GO_Central
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204899.
PharmGKBiPA165505227.

Polymorphism and mutation databases

BioMutaiMZT1.
DMDMi189037059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003370152 – 82Mitotic-spindle organizing protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ08AG7.
MaxQBiQ08AG7.
PaxDbiQ08AG7.
PeptideAtlasiQ08AG7.
PRIDEiQ08AG7.
TopDownProteomicsiQ08AG7.

PTM databases

iPTMnetiQ08AG7.
PhosphoSitePlusiQ08AG7.

Expressioni

Gene expression databases

BgeeiENSG00000204899.
CleanExiHS_C13orf37.
GenevisibleiQ08AG7. HS.

Organism-specific databases

HPAiHPA063299.
HPA066715.

Interactioni

Subunit structurei

Part of the gamma-tubulin complex. Interacts with TUBG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TUBG1P232583EBI-2637198,EBI-302589

GO - Molecular functioni

Protein-protein interaction databases

BioGridi136335. 40 interactors.
IntActiQ08AG7. 40 interactors.
STRINGi9606.ENSP00000367049.

Structurei

3D structure databases

ProteinModelPortaliQ08AG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 16Poly-Ala10

Sequence similaritiesi

Belongs to the MOZART1 family.Curated

Phylogenomic databases

eggNOGiENOG410J18H. Eukaryota.
ENOG410XVXZ. LUCA.
GeneTreeiENSGT00390000005954.
HOGENOMiHOG000217071.
HOVERGENiHBG107722.
InParanoidiQ08AG7.
KOiK18633.
OMAiTETLTIC.
OrthoDBiEOG091G17EG.
PhylomeDBiQ08AG7.
TreeFamiTF328444.

Family and domain databases

InterProiIPR022214. MZT1.
[Graphical view]
PANTHERiPTHR28520. PTHR28520. 1 hit.
PfamiPF12554. MOZART1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08AG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGAGAA AAAAAANLNA VRETMDVLLE ISRILNTGLD METLSICVRL
60 70 80
CEQGINPEAL SSVIKELRKA TEALKAAENM TS
Length:82
Mass (Da):8,479
Last modified:May 20, 2008 - v2
Checksum:iEA48466A00CF23C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0435625S → G.1 PublicationCorresponds to variant rs1465896dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356754, AL138695 Genomic DNA. Translation: CAH70226.1.
AL138695, AL356754 Genomic DNA. Translation: CAH72711.1.
BC125183 mRNA. Translation: AAI25184.1.
CCDSiCCDS31990.1.
RefSeqiNP_001065243.1. NM_001071775.2.
UniGeneiHs.28465.

Genome annotation databases

EnsembliENST00000377818; ENSP00000367049; ENSG00000204899.
GeneIDi440145.
KEGGihsa:440145.
UCSCiuc001viu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356754, AL138695 Genomic DNA. Translation: CAH70226.1.
AL138695, AL356754 Genomic DNA. Translation: CAH72711.1.
BC125183 mRNA. Translation: AAI25184.1.
CCDSiCCDS31990.1.
RefSeqiNP_001065243.1. NM_001071775.2.
UniGeneiHs.28465.

3D structure databases

ProteinModelPortaliQ08AG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136335. 40 interactors.
IntActiQ08AG7. 40 interactors.
STRINGi9606.ENSP00000367049.

PTM databases

iPTMnetiQ08AG7.
PhosphoSitePlusiQ08AG7.

Polymorphism and mutation databases

BioMutaiMZT1.
DMDMi189037059.

Proteomic databases

EPDiQ08AG7.
MaxQBiQ08AG7.
PaxDbiQ08AG7.
PeptideAtlasiQ08AG7.
PRIDEiQ08AG7.
TopDownProteomicsiQ08AG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377818; ENSP00000367049; ENSG00000204899.
GeneIDi440145.
KEGGihsa:440145.
UCSCiuc001viu.3. human.

Organism-specific databases

CTDi440145.
GeneCardsiMZT1.
HGNCiHGNC:33830. MZT1.
HPAiHPA063299.
HPA066715.
MIMi613448. gene.
neXtProtiNX_Q08AG7.
OpenTargetsiENSG00000204899.
PharmGKBiPA165505227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J18H. Eukaryota.
ENOG410XVXZ. LUCA.
GeneTreeiENSGT00390000005954.
HOGENOMiHOG000217071.
HOVERGENiHBG107722.
InParanoidiQ08AG7.
KOiK18633.
OMAiTETLTIC.
OrthoDBiEOG091G17EG.
PhylomeDBiQ08AG7.
TreeFamiTF328444.

Enzyme and pathway databases

BioCyciZFISH:G66-32813-MONOMER.

Miscellaneous databases

GenomeRNAii440145.
PROiQ08AG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204899.
CleanExiHS_C13orf37.
GenevisibleiQ08AG7. HS.

Family and domain databases

InterProiIPR022214. MZT1.
[Graphical view]
PANTHERiPTHR28520. PTHR28520. 1 hit.
PfamiPF12554. MOZART1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMZT1_HUMAN
AccessioniPrimary (citable) accession number: Q08AG7
Secondary accession number(s): Q5W0P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.