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Protein

Zinc finger protein 844

Gene

ZNF844

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 125C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri141 – 163C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32071-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 844
Gene namesi
Name:ZNF844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25932. ZNF844.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000223547.
PharmGKBiPA162410862.

Polymorphism and mutation databases

BioMutaiZNF844.
DMDMi121939996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003498771 – 666Zinc finger protein 844Add BLAST666

Proteomic databases

EPDiQ08AG5.
MaxQBiQ08AG5.
PaxDbiQ08AG5.
PeptideAtlasiQ08AG5.
PRIDEiQ08AG5.

PTM databases

iPTMnetiQ08AG5.
PhosphoSitePlusiQ08AG5.

Expressioni

Gene expression databases

BgeeiENSG00000223547.
CleanExiHS_ZNF844.
ExpressionAtlasiQ08AG5. baseline and differential.
GenevisibleiQ08AG5. HS.

Organism-specific databases

HPAiHPA046982.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10225757,EBI-10171697
KRTAP10-9P604113EBI-10225757,EBI-10172052
MDFIQ997505EBI-10225757,EBI-724076
MTUS2Q5JR593EBI-10225757,EBI-742948
NDEL1Q9GZM85EBI-10225757,EBI-928842

Protein-protein interaction databases

BioGridi129858. 5 interactors.
IntActiQ08AG5. 9 interactors.
STRINGi9606.ENSP00000392024.

Structurei

3D structure databases

ProteinModelPortaliQ08AG5.
SMRiQ08AG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 125C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri141 – 163C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08AG5.
OMAiHEITHIG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ08AG5.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08AG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVAFEDVA VNFTQEEWSL LDPSQKNLYR EVMQETLRNL ASIGEKWKDQ
60 70 80 90 100
NIEDQYKNPR NNLRSLLGER VDENTEENHC GETSSQIPDD TLNKKTSPGV
110 120 130 140 150
KSCESSVCGE VFVGHSSLNR HIRADTAHKP SEYQEYGQEP YKCQQRKKAF
160 170 180 190 200
RCHPSFQMQE KAHTGEKLYD CKECGKTFIS HSSIQRHMIM HNGDGTYKCK
210 220 230 240 250
FCGKACPCLS IYLIHERVHT GEKPYKCKQC GKAFSYSTSL QIHERTHTGE
260 270 280 290 300
KPYECKECGK AFGSPNSLYE HRRTHTGEKP YECKQCGKAF RWFHSFQIHE
310 320 330 340 350
RTHSEEKAYE CTKCGKAFKC PSYLCRHEVT HSGKKPCECK QCGKALSYLN
360 370 380 390 400
FQRHMKMHTR MRPYKCKTVE KPLILPVRFE DMKELTLERN LMNASTVVKP
410 420 430 440 450
SIVPVPFTIM KGLTLERNPM NVSSVVKPSF LPLPFDIMKG LTLERNRMSV
460 470 480 490 500
SNVGKPSDLP HTFKCMEGLT LKRNPMNVSS VVKPSFFPLP FDIMKGLTLE
510 520 530 540 550
RNPMSVSNVG KPSHLPHTFK CMKGLTLESN CMNLNNVKKP LDLSETFKFM
560 570 580 590 600
KRHTLERNPI RNMEKHSTIS LPFKYMQQCT EDRMPMNVKS VTKHSYLPRS
610 620 630 640 650
FEYMQEHTLE RNPMNVRNAE KRSIIFLLCV YTKGCTLERN HINVRIVGKH
660
SVCLVPFVDI KGLTLE
Length:666
Mass (Da):76,934
Last modified:October 31, 2006 - v1
Checksum:iAB7CEEBC7A2083D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177T → A in CAI46141 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059941113V → M.Corresponds to variant rs12611158dbSNPEnsembl.1
Natural variantiVAR_059942146R → H.Corresponds to variant rs10422576dbSNPEnsembl.1
Natural variantiVAR_059943226K → E.Corresponds to variant rs7259684dbSNPEnsembl.1
Natural variantiVAR_059944276T → A.Corresponds to variant rs7259845dbSNPEnsembl.1
Natural variantiVAR_059945308A → P.Corresponds to variant rs6511763dbSNPEnsembl.1
Natural variantiVAR_059946329V → A.Corresponds to variant rs8102258dbSNPEnsembl.1
Natural variantiVAR_059947584M → L.Corresponds to variant rs1438694dbSNPEnsembl.1
Natural variantiVAR_059948642I → M.Corresponds to variant rs10426017dbSNPEnsembl.1
Natural variantiVAR_061980658V → I.Corresponds to variant rs55703333dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098117 mRNA. Translation: BAG53579.1.
AL832297 mRNA. Translation: CAI46141.1.
CH471106 Genomic DNA. Translation: EAW84257.1.
BC125186 mRNA. Translation: AAI25187.1.
CCDSiCCDS45985.1.
RefSeqiNP_001129973.1. NM_001136501.2.
UniGeneiHs.646391.

Genome annotation databases

EnsembliENST00000439326; ENSP00000392024; ENSG00000223547.
GeneIDi284391.
KEGGihsa:284391.
UCSCiuc002mtb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098117 mRNA. Translation: BAG53579.1.
AL832297 mRNA. Translation: CAI46141.1.
CH471106 Genomic DNA. Translation: EAW84257.1.
BC125186 mRNA. Translation: AAI25187.1.
CCDSiCCDS45985.1.
RefSeqiNP_001129973.1. NM_001136501.2.
UniGeneiHs.646391.

3D structure databases

ProteinModelPortaliQ08AG5.
SMRiQ08AG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129858. 5 interactors.
IntActiQ08AG5. 9 interactors.
STRINGi9606.ENSP00000392024.

PTM databases

iPTMnetiQ08AG5.
PhosphoSitePlusiQ08AG5.

Polymorphism and mutation databases

BioMutaiZNF844.
DMDMi121939996.

Proteomic databases

EPDiQ08AG5.
MaxQBiQ08AG5.
PaxDbiQ08AG5.
PeptideAtlasiQ08AG5.
PRIDEiQ08AG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439326; ENSP00000392024; ENSG00000223547.
GeneIDi284391.
KEGGihsa:284391.
UCSCiuc002mtb.3. human.

Organism-specific databases

CTDi284391.
GeneCardsiZNF844.
HGNCiHGNC:25932. ZNF844.
HPAiHPA046982.
neXtProtiNX_Q08AG5.
OpenTargetsiENSG00000223547.
PharmGKBiPA162410862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08AG5.
OMAiHEITHIG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ08AG5.
TreeFamiTF338854.

Enzyme and pathway databases

BioCyciZFISH:G66-32071-MONOMER.

Miscellaneous databases

GenomeRNAii284391.
PROiQ08AG5.

Gene expression databases

BgeeiENSG00000223547.
CleanExiHS_ZNF844.
ExpressionAtlasiQ08AG5. baseline and differential.
GenevisibleiQ08AG5. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN844_HUMAN
AccessioniPrimary (citable) accession number: Q08AG5
Secondary accession number(s): Q5JPI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.