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Protein

Zinc finger protein 844

Gene

ZNF844

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 125C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri141 – 163C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 844
Gene namesi
Name:ZNF844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000223547.9
HGNCiHGNC:25932 ZNF844
neXtProtiNX_Q08AG5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000223547
PharmGKBiPA162410862

Polymorphism and mutation databases

BioMutaiZNF844
DMDMi121939996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003498771 – 666Zinc finger protein 844Add BLAST666

Proteomic databases

MaxQBiQ08AG5
PaxDbiQ08AG5
PeptideAtlasiQ08AG5
PRIDEiQ08AG5
ProteomicsDBi58668

PTM databases

iPTMnetiQ08AG5
PhosphoSitePlusiQ08AG5

Expressioni

Gene expression databases

BgeeiENSG00000223547
CleanExiHS_ZNF844
ExpressionAtlasiQ08AG5 baseline and differential
GenevisibleiQ08AG5 HS

Organism-specific databases

HPAiHPA046982

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129858, 5 interactors
IntActiQ08AG5, 10 interactors
STRINGi9606.ENSP00000392024

Structurei

3D structure databases

ProteinModelPortaliQ08AG5
SMRiQ08AG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 125C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri141 – 163C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ08AG5
OMAiGPMNVRN
OrthoDBiEOG091G02KC
PhylomeDBiQ08AG5
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

Q08AG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVAFEDVA VNFTQEEWSL LDPSQKNLYR EVMQETLRNL ASIGEKWKDQ
60 70 80 90 100
NIEDQYKNPR NNLRSLLGER VDENTEENHC GETSSQIPDD TLNKKTSPGV
110 120 130 140 150
KSCESSVCGE VFVGHSSLNR HIRADTAHKP SEYQEYGQEP YKCQQRKKAF
160 170 180 190 200
RCHPSFQMQE KAHTGEKLYD CKECGKTFIS HSSIQRHMIM HNGDGTYKCK
210 220 230 240 250
FCGKACPCLS IYLIHERVHT GEKPYKCKQC GKAFSYSTSL QIHERTHTGE
260 270 280 290 300
KPYECKECGK AFGSPNSLYE HRRTHTGEKP YECKQCGKAF RWFHSFQIHE
310 320 330 340 350
RTHSEEKAYE CTKCGKAFKC PSYLCRHEVT HSGKKPCECK QCGKALSYLN
360 370 380 390 400
FQRHMKMHTR MRPYKCKTVE KPLILPVRFE DMKELTLERN LMNASTVVKP
410 420 430 440 450
SIVPVPFTIM KGLTLERNPM NVSSVVKPSF LPLPFDIMKG LTLERNRMSV
460 470 480 490 500
SNVGKPSDLP HTFKCMEGLT LKRNPMNVSS VVKPSFFPLP FDIMKGLTLE
510 520 530 540 550
RNPMSVSNVG KPSHLPHTFK CMKGLTLESN CMNLNNVKKP LDLSETFKFM
560 570 580 590 600
KRHTLERNPI RNMEKHSTIS LPFKYMQQCT EDRMPMNVKS VTKHSYLPRS
610 620 630 640 650
FEYMQEHTLE RNPMNVRNAE KRSIIFLLCV YTKGCTLERN HINVRIVGKH
660
SVCLVPFVDI KGLTLE
Length:666
Mass (Da):76,934
Last modified:October 31, 2006 - v1
Checksum:iAB7CEEBC7A2083D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177T → A in CAI46141 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059941113V → M. Corresponds to variant dbSNP:rs12611158Ensembl.1
Natural variantiVAR_059942146R → H. Corresponds to variant dbSNP:rs10422576Ensembl.1
Natural variantiVAR_059943226K → E. Corresponds to variant dbSNP:rs7259684Ensembl.1
Natural variantiVAR_059944276T → A. Corresponds to variant dbSNP:rs7259845Ensembl.1
Natural variantiVAR_059945308A → P. Corresponds to variant dbSNP:rs6511763Ensembl.1
Natural variantiVAR_059946329V → A. Corresponds to variant dbSNP:rs8102258Ensembl.1
Natural variantiVAR_059947584M → L. Corresponds to variant dbSNP:rs1438694Ensembl.1
Natural variantiVAR_059948642I → M. Corresponds to variant dbSNP:rs10426017Ensembl.1
Natural variantiVAR_061980658V → I. Corresponds to variant dbSNP:rs55703333Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098117 mRNA Translation: BAG53579.1
AL832297 mRNA Translation: CAI46141.1
CH471106 Genomic DNA Translation: EAW84257.1
BC125186 mRNA Translation: AAI25187.1
CCDSiCCDS45985.1
RefSeqiNP_001129973.1, NM_001136501.2
UniGeneiHs.646391

Genome annotation databases

EnsembliENST00000439326; ENSP00000392024; ENSG00000223547
GeneIDi284391
KEGGihsa:284391
UCSCiuc002mtb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN844_HUMAN
AccessioniPrimary (citable) accession number: Q08AG5
Secondary accession number(s): Q5JPI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2006
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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