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Protein

Zinc finger protein 844

Gene

ZNF844

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12525C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri141 – 16323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35822C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 844
Gene namesi
Name:ZNF844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25932. ZNF844.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410862.

Polymorphism and mutation databases

BioMutaiZNF844.
DMDMi121939996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Zinc finger protein 844PRO_0000349877Add
BLAST

Proteomic databases

MaxQBiQ08AG5.
PaxDbiQ08AG5.
PRIDEiQ08AG5.

PTM databases

PhosphoSiteiQ08AG5.

Expressioni

Gene expression databases

BgeeiQ08AG5.
CleanExiHS_ZNF844.
ExpressionAtlasiQ08AG5. baseline and differential.
GenevisibleiQ08AG5. HS.

Organism-specific databases

HPAiHPA046982.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10225757,EBI-10171697
KRTAP10-9P604113EBI-10225757,EBI-10172052
MDFIQ997503EBI-10225757,EBI-724076
MTUS2Q5JR593EBI-10225757,EBI-742948
NDEL1Q9GZM83EBI-10225757,EBI-928842

Protein-protein interaction databases

BioGridi129858. 5 interactions.
IntActiQ08AG5. 5 interactions.
STRINGi9606.ENSP00000392024.

Structurei

3D structure databases

ProteinModelPortaliQ08AG5.
SMRiQ08AG5. Positions 4-54, 80-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8683KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12525C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri141 – 16323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri169 – 19123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35822C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08AG5.
OMAiHEITHIG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ08AG5.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08AG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVAFEDVA VNFTQEEWSL LDPSQKNLYR EVMQETLRNL ASIGEKWKDQ
60 70 80 90 100
NIEDQYKNPR NNLRSLLGER VDENTEENHC GETSSQIPDD TLNKKTSPGV
110 120 130 140 150
KSCESSVCGE VFVGHSSLNR HIRADTAHKP SEYQEYGQEP YKCQQRKKAF
160 170 180 190 200
RCHPSFQMQE KAHTGEKLYD CKECGKTFIS HSSIQRHMIM HNGDGTYKCK
210 220 230 240 250
FCGKACPCLS IYLIHERVHT GEKPYKCKQC GKAFSYSTSL QIHERTHTGE
260 270 280 290 300
KPYECKECGK AFGSPNSLYE HRRTHTGEKP YECKQCGKAF RWFHSFQIHE
310 320 330 340 350
RTHSEEKAYE CTKCGKAFKC PSYLCRHEVT HSGKKPCECK QCGKALSYLN
360 370 380 390 400
FQRHMKMHTR MRPYKCKTVE KPLILPVRFE DMKELTLERN LMNASTVVKP
410 420 430 440 450
SIVPVPFTIM KGLTLERNPM NVSSVVKPSF LPLPFDIMKG LTLERNRMSV
460 470 480 490 500
SNVGKPSDLP HTFKCMEGLT LKRNPMNVSS VVKPSFFPLP FDIMKGLTLE
510 520 530 540 550
RNPMSVSNVG KPSHLPHTFK CMKGLTLESN CMNLNNVKKP LDLSETFKFM
560 570 580 590 600
KRHTLERNPI RNMEKHSTIS LPFKYMQQCT EDRMPMNVKS VTKHSYLPRS
610 620 630 640 650
FEYMQEHTLE RNPMNVRNAE KRSIIFLLCV YTKGCTLERN HINVRIVGKH
660
SVCLVPFVDI KGLTLE
Length:666
Mass (Da):76,934
Last modified:October 31, 2006 - v1
Checksum:iAB7CEEBC7A2083D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771T → A in CAI46141 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → M.
Corresponds to variant rs12611158 [ dbSNP | Ensembl ].
VAR_059941
Natural varianti146 – 1461R → H.
Corresponds to variant rs10422576 [ dbSNP | Ensembl ].
VAR_059942
Natural varianti226 – 2261K → E.
Corresponds to variant rs7259684 [ dbSNP | Ensembl ].
VAR_059943
Natural varianti276 – 2761T → A.
Corresponds to variant rs7259845 [ dbSNP | Ensembl ].
VAR_059944
Natural varianti308 – 3081A → P.
Corresponds to variant rs6511763 [ dbSNP | Ensembl ].
VAR_059945
Natural varianti329 – 3291V → A.
Corresponds to variant rs8102258 [ dbSNP | Ensembl ].
VAR_059946
Natural varianti584 – 5841M → L.
Corresponds to variant rs1438694 [ dbSNP | Ensembl ].
VAR_059947
Natural varianti642 – 6421I → M.
Corresponds to variant rs10426017 [ dbSNP | Ensembl ].
VAR_059948
Natural varianti658 – 6581V → I.
Corresponds to variant rs55703333 [ dbSNP | Ensembl ].
VAR_061980

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098117 mRNA. Translation: BAG53579.1.
AL832297 mRNA. Translation: CAI46141.1.
CH471106 Genomic DNA. Translation: EAW84257.1.
BC125186 mRNA. Translation: AAI25187.1.
CCDSiCCDS45985.1.
RefSeqiNP_001129973.1. NM_001136501.2.
UniGeneiHs.646391.

Genome annotation databases

EnsembliENST00000439326; ENSP00000392024; ENSG00000223547.
GeneIDi284391.
KEGGihsa:284391.
UCSCiuc002mtb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098117 mRNA. Translation: BAG53579.1.
AL832297 mRNA. Translation: CAI46141.1.
CH471106 Genomic DNA. Translation: EAW84257.1.
BC125186 mRNA. Translation: AAI25187.1.
CCDSiCCDS45985.1.
RefSeqiNP_001129973.1. NM_001136501.2.
UniGeneiHs.646391.

3D structure databases

ProteinModelPortaliQ08AG5.
SMRiQ08AG5. Positions 4-54, 80-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129858. 5 interactions.
IntActiQ08AG5. 5 interactions.
STRINGi9606.ENSP00000392024.

PTM databases

PhosphoSiteiQ08AG5.

Polymorphism and mutation databases

BioMutaiZNF844.
DMDMi121939996.

Proteomic databases

MaxQBiQ08AG5.
PaxDbiQ08AG5.
PRIDEiQ08AG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439326; ENSP00000392024; ENSG00000223547.
GeneIDi284391.
KEGGihsa:284391.
UCSCiuc002mtb.3. human.

Organism-specific databases

CTDi284391.
GeneCardsiZNF844.
HGNCiHGNC:25932. ZNF844.
HPAiHPA046982.
neXtProtiNX_Q08AG5.
PharmGKBiPA162410862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ08AG5.
OMAiHEITHIG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ08AG5.
TreeFamiTF338854.

Miscellaneous databases

GenomeRNAii284391.
NextBioi94822.
PROiQ08AG5.

Gene expression databases

BgeeiQ08AG5.
CleanExiHS_ZNF844.
ExpressionAtlasiQ08AG5. baseline and differential.
GenevisibleiQ08AG5. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZN844_HUMAN
AccessioniPrimary (citable) accession number: Q08AG5
Secondary accession number(s): Q5JPI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 31, 2006
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.