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Protein

Putative golgin subfamily A member 8F/8G

Gene

GOLGA8F

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative golgin subfamily A member 8F/8G
Gene namesi
Name:GOLGA8F
AND
Name:GOLGA8G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000153684.14.
HGNCiHGNC:32378. GOLGA8F.
HGNC:25328. GOLGA8G.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153684.

Polymorphism and mutation databases

DMDMi121939991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003149681 – 430Putative golgin subfamily A member 8F/8GAdd BLAST430

Proteomic databases

PaxDbiQ08AF8.
PeptideAtlasiQ08AF8.
PRIDEiQ08AF8.

PTM databases

iPTMnetiQ08AF8.

Expressioni

Gene expression databases

BgeeiENSG00000153684.
CleanExiHS_GOLGA8G.
ExpressionAtlasiQ08AF8. baseline.
GenevisibleiQ08AF8. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ08AF8. 22 interactors.
STRINGi9606.ENSP00000458130.

Structurei

3D structure databases

ProteinModelPortaliQ08AF8.
SMRiQ08AF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 217Sequence analysisAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi427 – 430Poly-Arg4

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
InParanoidiQ08AF8.
OrthoDBiEOG091G0DDT.
PhylomeDBiQ08AF8.

Family and domain databases

InterProiView protein in InterPro
IPR024858. Golgin_A.
PfamiView protein in Pfam
PF15070. GOLGA2L5. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08AF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWKLEQSMR EQALLKAQLT QLKESLKEVQ LERDEYAEHL KGERARWQQR
60 70 80 90 100
MRKMSQEVCS LKKEKKHDKY RVEKLERSLS KLKHQMAEPL PPEPPAVPSE
110 120 130 140 150
VELQHLRKEL ERVAGELQAQ VEYNQRISLL NEGQKERLRE QEERLQEQQE
160 170 180 190 200
RLPEQEERLQ QLAEPQNSFK ELNNENKSVL QLEQQVKELQ EKLGKERLEA
210 220 230 240 250
ASQQKQQLTA QLSLMALPGE GDGGGHLDSE GEEAPRPIPS IPQDLESREA
260 270 280 290 300
MSGFMDHLEE KADLSELVEK EELGFFQYYR ERCHQKVYHP ITKPGGSAKD
310 320 330 340 350
AAPGGGHHQA GPGQGGDEGE AAGAAGDGVA AGGDYKGHSK FLVTAQNPAH
360 370 380 390 400
EPSPGAPAPQ ELGAAHKHGD LCEVSLTDSV EPVQGEAREG SPHDNPTAQP
410 420 430
IVQDHQEHPG LGSNCCVPFF CWAWLPRRRR
Length:430
Mass (Da):48,405
Last modified:October 31, 2006 - v1
Checksum:iC758D5AF42EC4171
GO
Isoform 2 (identifier: Q08AF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-267: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,550
Checksum:i008A9E2F67385718
GO
Isoform 3 (identifier: Q08AF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-195: K → KVKET

Show »
Length:434
Mass (Da):48,863
Checksum:i1307A908C841659E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232E → K in BC066774 (PubMed:15489334).Curated1
Sequence conflicti391S → P in AAH99913 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035081121 – 267Missing in isoform 2. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_037944195K → KVKET in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309038 mRNA. Translation: ABD73922.1.
AC138749 Genomic DNA. No translation available.
BC066774 mRNA. No translation available.
BC099913 mRNA. Translation: AAH99913.1.
BC125193 mRNA. Translation: AAI25194.1.
BC125194 mRNA. Translation: AAI25195.1.
BC150302 mRNA. Translation: AAI50303.1.
AL833871 mRNA. Translation: CAD38728.1.
UniGeneiHs.169639.
Hs.510812.
Hs.592025.

Genome annotation databases

EnsembliENST00000329523; ENSP00000457934; ENSG00000183629.
ENST00000526619; ENSP00000456138; ENSG00000153684. [Q08AF8-1]
ENST00000612831; ENSP00000481013; ENSG00000277090.
UCSCiuc001zbp.4. human. [Q08AF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGOG8F_HUMAN
AccessioniPrimary (citable) accession number: Q08AF8
Secondary accession number(s): A4FTY1, Q1A5X9, Q8NDK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families