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Protein

Putative golgin subfamily A member 8F/8G

Gene

GOLGA8F

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein uncertaini

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33776-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative golgin subfamily A member 8F/8G
Gene namesi
Name:GOLGA8F
AND
Name:GOLGA8G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:32378. GOLGA8F.
HGNC:25328. GOLGA8G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153684.

Polymorphism and mutation databases

DMDMi121939991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003149681 – 430Putative golgin subfamily A member 8F/8GAdd BLAST430

Proteomic databases

PaxDbiQ08AF8.
PeptideAtlasiQ08AF8.
PRIDEiQ08AF8.

PTM databases

iPTMnetiQ08AF8.

Expressioni

Gene expression databases

BgeeiENSG00000153684.
CleanExiHS_GOLGA8G.
ExpressionAtlasiQ08AF8. differential.
GenevisibleiQ08AF8. HS.

Organism-specific databases

HPAiCAB000012.
CAB075722.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF4P188483EBI-10181260,EBI-492498
ATF4Q96AQ33EBI-10181260,EBI-740263
BAATQ140323EBI-10181260,EBI-8994378
BEX3Q009943EBI-10181260,EBI-741753
BEX5Q5H9J73EBI-10181260,EBI-10243741
CDC5LQ994593EBI-10181260,EBI-374880
GOSR2O146535EBI-10181260,EBI-4401517
HDDC3Q8N4P33EBI-10181260,EBI-750003
KCTD6Q8NC693EBI-10181260,EBI-2511344
MEOX2A4D1273EBI-10181260,EBI-10172134
MRFAP1Q9Y6053EBI-10181260,EBI-995714
PDE4DQ084993EBI-10181260,EBI-1642831
PDE4DIPQ5VU433EBI-10181260,EBI-1105124
SPAG5Q96R063EBI-10181260,EBI-413317
SSX2IPQ9Y2D83EBI-10181260,EBI-2212028
STX11O755583EBI-10181260,EBI-714135
TCF4P158843EBI-10181260,EBI-533224
USHBP1Q8N6Y03EBI-10181260,EBI-739895

Protein-protein interaction databases

IntActiQ08AF8. 20 interactors.
STRINGi9606.ENSP00000458130.

Structurei

3D structure databases

ProteinModelPortaliQ08AF8.
SMRiQ08AF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 217Sequence analysisAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi427 – 430Poly-Arg4

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
InParanoidiQ08AF8.
OrthoDBiEOG091G0DDT.
PhylomeDBiQ08AF8.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PfamiPF15070. GOLGA2L5. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08AF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWKLEQSMR EQALLKAQLT QLKESLKEVQ LERDEYAEHL KGERARWQQR
60 70 80 90 100
MRKMSQEVCS LKKEKKHDKY RVEKLERSLS KLKHQMAEPL PPEPPAVPSE
110 120 130 140 150
VELQHLRKEL ERVAGELQAQ VEYNQRISLL NEGQKERLRE QEERLQEQQE
160 170 180 190 200
RLPEQEERLQ QLAEPQNSFK ELNNENKSVL QLEQQVKELQ EKLGKERLEA
210 220 230 240 250
ASQQKQQLTA QLSLMALPGE GDGGGHLDSE GEEAPRPIPS IPQDLESREA
260 270 280 290 300
MSGFMDHLEE KADLSELVEK EELGFFQYYR ERCHQKVYHP ITKPGGSAKD
310 320 330 340 350
AAPGGGHHQA GPGQGGDEGE AAGAAGDGVA AGGDYKGHSK FLVTAQNPAH
360 370 380 390 400
EPSPGAPAPQ ELGAAHKHGD LCEVSLTDSV EPVQGEAREG SPHDNPTAQP
410 420 430
IVQDHQEHPG LGSNCCVPFF CWAWLPRRRR
Length:430
Mass (Da):48,405
Last modified:October 31, 2006 - v1
Checksum:iC758D5AF42EC4171
GO
Isoform 2 (identifier: Q08AF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-267: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,550
Checksum:i008A9E2F67385718
GO
Isoform 3 (identifier: Q08AF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-195: K → KVKET

Show »
Length:434
Mass (Da):48,863
Checksum:i1307A908C841659E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232E → K in BC066774 (PubMed:15489334).Curated1
Sequence conflicti391S → P in AAH99913 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035081121 – 267Missing in isoform 2. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_037944195K → KVKET in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309038 mRNA. Translation: ABD73922.1.
AC138749 Genomic DNA. No translation available.
BC066774 mRNA. No translation available.
BC099913 mRNA. Translation: AAH99913.1.
BC125193 mRNA. Translation: AAI25194.1.
BC125194 mRNA. Translation: AAI25195.1.
BC150302 mRNA. Translation: AAI50303.1.
AL833871 mRNA. Translation: CAD38728.1.
UniGeneiHs.169639.
Hs.510812.
Hs.592025.

Genome annotation databases

EnsembliENST00000329523; ENSP00000457934; ENSG00000183629.
ENST00000526619; ENSP00000456138; ENSG00000153684. [Q08AF8-1]
ENST00000612831; ENSP00000481013; ENSG00000277090.
UCSCiuc001zbp.4. human. [Q08AF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309038 mRNA. Translation: ABD73922.1.
AC138749 Genomic DNA. No translation available.
BC066774 mRNA. No translation available.
BC099913 mRNA. Translation: AAH99913.1.
BC125193 mRNA. Translation: AAI25194.1.
BC125194 mRNA. Translation: AAI25195.1.
BC150302 mRNA. Translation: AAI50303.1.
AL833871 mRNA. Translation: CAD38728.1.
UniGeneiHs.169639.
Hs.510812.
Hs.592025.

3D structure databases

ProteinModelPortaliQ08AF8.
SMRiQ08AF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ08AF8. 20 interactors.
STRINGi9606.ENSP00000458130.

PTM databases

iPTMnetiQ08AF8.

Polymorphism and mutation databases

DMDMi121939991.

Proteomic databases

PaxDbiQ08AF8.
PeptideAtlasiQ08AF8.
PRIDEiQ08AF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329523; ENSP00000457934; ENSG00000183629.
ENST00000526619; ENSP00000456138; ENSG00000153684. [Q08AF8-1]
ENST00000612831; ENSP00000481013; ENSG00000277090.
UCSCiuc001zbp.4. human. [Q08AF8-1]

Organism-specific databases

GeneCardsiGOLGA8F.
GOLGA8G.
HGNCiHGNC:32378. GOLGA8F.
HGNC:25328. GOLGA8G.
HPAiCAB000012.
CAB075722.
neXtProtiNX_Q08AF8.
OpenTargetsiENSG00000153684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
InParanoidiQ08AF8.
OrthoDBiEOG091G0DDT.
PhylomeDBiQ08AF8.

Enzyme and pathway databases

BioCyciZFISH:G66-33776-MONOMER.

Gene expression databases

BgeeiENSG00000153684.
CleanExiHS_GOLGA8G.
ExpressionAtlasiQ08AF8. differential.
GenevisibleiQ08AF8. HS.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PfamiPF15070. GOLGA2L5. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOG8F_HUMAN
AccessioniPrimary (citable) accession number: Q08AF8
Secondary accession number(s): A4FTY1, Q1A5X9, Q8NDK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.