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Protein

Schlafen family member 5

Gene

SLFN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in hematopoietic cell differentiation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi578 – 5858ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 5
Gene namesi
Name:SLFN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28286. SLFN5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596357.

Polymorphism and mutation databases

BioMutaiSLFN5.
DMDMi121939987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 891891Schlafen family member 5PRO_0000282982Add
BLAST

Proteomic databases

EPDiQ08AF3.
MaxQBiQ08AF3.
PaxDbiQ08AF3.
PeptideAtlasiQ08AF3.
PRIDEiQ08AF3.

PTM databases

iPTMnetiQ08AF3.
PhosphoSiteiQ08AF3.
SwissPalmiQ08AF3.

Expressioni

Gene expression databases

BgeeiQ08AF3.
CleanExiHS_SLFN5.
ExpressionAtlasiQ08AF3. baseline and differential.
GenevisibleiQ08AF3. HS.

Organism-specific databases

HPAiHPA017760.

Interactioni

Protein-protein interaction databases

BioGridi127815. 5 interactions.
IntActiQ08AF3. 5 interactions.
STRINGi9606.ENSP00000299977.

Structurei

3D structure databases

ProteinModelPortaliQ08AF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family.Curated

Phylogenomic databases

eggNOGiENOG410IJEW. Eukaryota.
ENOG410Z5MV. LUCA.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000049135.
HOVERGENiHBG056880.
InParanoidiQ08AF3.
OMAiTLCSNLY.
OrthoDBiEOG712TVN.
PhylomeDBiQ08AF3.
TreeFamiTF337168.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR018647. DUF2075.
IPR027417. P-loop_NTPase.
IPR029684. Schlafen.
IPR007421. Schlafen_AAA_dom.
IPR029671. Slfn5.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF26. PTHR12155:SF26. 1 hit.
PfamiPF04326. AlbA_2. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08AF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLRIDVDTN FPECVVDAGK VTLGTQQRQE MDPRLREKQN EIILRAVCAL
60 70 80 90 100
LNSGGGIIKA EIENKGYNYE RHGVGLDVPP IFRSHLDKMQ KENHFLIFVK
110 120 130 140 150
SWNTEAGVPL ATLCSNLYHR ERTSTDVMDS QEALAFLKCR TQTPTNINVS
160 170 180 190 200
NSLGPQAAQG SVQYEGNINV SAAALFDRKR LQYLEKLNLP ESTHVEFVMF
210 220 230 240 250
STDVSHCVKD RLPKCVSAFA NTEGGYVFFG VHDETCQVIG CEKEKIDLTS
260 270 280 290 300
LRASIDGCIK KLPVHHFCTQ RPEIKYVLNF LEVHDKGALR GYVCAIKVEK
310 320 330 340 350
FCCAVFAKVP SSWQVKDNRV RQLPTREWTA WMMEADPDLS RCPEMVLQLS
360 370 380 390 400
LSSATPRSKP VCIHKNSECL KEQQKRYFPV FSDRVVYTPE SLYKELFSQH
410 420 430 440 450
KGLRDLINTE MRPFSQGILI FSQSWAVDLG LQEKQGVICD ALLISQNNTP
460 470 480 490 500
ILYTIFSKWD AGCKGYSMIV AYSLKQKLVN KGGYTGRLCI TPLVCVLNSD
510 520 530 540 550
RKAQSVYSSY LQIYPESYNF MTPQHMEALL QSLVIVLLGF KSFLSEELGS
560 570 580 590 600
EVLNLLTNKQ YELLSKNLRK TRELFVHGLP GSGKTILALR IMEKIRNVFH
610 620 630 640 650
CEPANILYIC ENQPLKKLVS FSKKNICQPV TRKTFMKNNF EHIQHIIIDD
660 670 680 690 700
AQNFRTEDGD WYGKAKFITQ TARDGPGVLW IFLDYFQTYH LSCSGLPPPS
710 720 730 740 750
DQYPREEINR VVRNAGPIAN YLQQVMQEAR QNPPPNLPPG SLVMLYEPKW
760 770 780 790 800
AQGVPGNLEI IEDLNLEEIL IYVANKCRFL LRNGYSPKDI AVLFTKASEV
810 820 830 840 850
EKYKDRLLTA MRKRKLSQLH EESDLLLQIG DASDVLTDHI VLDSVCRFSG
860 870 880 890
LERNIVFGIN PGVAPPAGAY NLLLCLASRA KRHLYILKAS V
Length:891
Mass (Da):101,055
Last modified:October 31, 2006 - v1
Checksum:i52F2AC3259251AB5
GO
Isoform 2 (identifier: Q08AF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: D → G
     339-891: Missing.

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):38,103
Checksum:iF321EDDA06C592FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831Y → H in AAI25202 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti754 – 7541V → L.
Corresponds to variant rs16970806 [ dbSNP | Ensembl ].
VAR_053876
Natural varianti787 – 7871P → L.1 Publication
Corresponds to variant rs11651240 [ dbSNP | Ensembl ].
VAR_031445
Natural varianti797 – 7971A → V.
Corresponds to variant rs2291189 [ dbSNP | Ensembl ].
VAR_031446

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 3381D → G in isoform 2. 1 PublicationVSP_024271
Alternative sequencei339 – 891553Missing in isoform 2. 1 PublicationVSP_024272Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021238 mRNA. Translation: AAH21238.1.
BC125200 mRNA. Translation: AAI25201.1.
BC125201 mRNA. Translation: AAI25202.1.
AK054668 mRNA. Translation: BAB70788.1.
CCDSiCCDS32619.1. [Q08AF3-1]
RefSeqiNP_659412.3. NM_144975.3. [Q08AF3-1]
UniGeneiHs.709347.

Genome annotation databases

EnsembliENST00000299977; ENSP00000299977; ENSG00000166750. [Q08AF3-1]
ENST00000592325; ENSP00000466984; ENSG00000166750. [Q08AF3-2]
GeneIDi162394.
KEGGihsa:162394.
UCSCiuc002hje.4. human. [Q08AF3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021238 mRNA. Translation: AAH21238.1.
BC125200 mRNA. Translation: AAI25201.1.
BC125201 mRNA. Translation: AAI25202.1.
AK054668 mRNA. Translation: BAB70788.1.
CCDSiCCDS32619.1. [Q08AF3-1]
RefSeqiNP_659412.3. NM_144975.3. [Q08AF3-1]
UniGeneiHs.709347.

3D structure databases

ProteinModelPortaliQ08AF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127815. 5 interactions.
IntActiQ08AF3. 5 interactions.
STRINGi9606.ENSP00000299977.

PTM databases

iPTMnetiQ08AF3.
PhosphoSiteiQ08AF3.
SwissPalmiQ08AF3.

Polymorphism and mutation databases

BioMutaiSLFN5.
DMDMi121939987.

Proteomic databases

EPDiQ08AF3.
MaxQBiQ08AF3.
PaxDbiQ08AF3.
PeptideAtlasiQ08AF3.
PRIDEiQ08AF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299977; ENSP00000299977; ENSG00000166750. [Q08AF3-1]
ENST00000592325; ENSP00000466984; ENSG00000166750. [Q08AF3-2]
GeneIDi162394.
KEGGihsa:162394.
UCSCiuc002hje.4. human. [Q08AF3-1]

Organism-specific databases

CTDi162394.
GeneCardsiSLFN5.
HGNCiHGNC:28286. SLFN5.
HPAiHPA017760.
MIMi614952. gene.
neXtProtiNX_Q08AF3.
PharmGKBiPA144596357.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJEW. Eukaryota.
ENOG410Z5MV. LUCA.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000049135.
HOVERGENiHBG056880.
InParanoidiQ08AF3.
OMAiTLCSNLY.
OrthoDBiEOG712TVN.
PhylomeDBiQ08AF3.
TreeFamiTF337168.

Miscellaneous databases

GenomeRNAii162394.
NextBioi88161.
PROiQ08AF3.
SOURCEiSearch...

Gene expression databases

BgeeiQ08AF3.
CleanExiHS_SLFN5.
ExpressionAtlasiQ08AF3. baseline and differential.
GenevisibleiQ08AF3. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR018647. DUF2075.
IPR027417. P-loop_NTPase.
IPR029684. Schlafen.
IPR007421. Schlafen_AAA_dom.
IPR029671. Slfn5.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF26. PTHR12155:SF26. 1 hit.
PfamiPF04326. AlbA_2. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-782 (ISOFORM 1), VARIANT LEU-787.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSLFN5_HUMAN
AccessioniPrimary (citable) accession number: Q08AF3
Secondary accession number(s): Q08AF2, Q8WU54, Q96A82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 31, 2006
Last modified: April 13, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.