Q08A51 (DNAA_SHEFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	Sfri_0001

Organism

Shewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]

Taxonomic identifier

318167 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048719
Regions
	Nucleotide binding	166 – 173	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q08A51 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: EC5413F955678BD6	FASTA	461	52,166
	10 20 30 40 50 60 MAVSLWQQCI GRLQDELSAQ QFSMWIRPLQ AEMDGDTLVL YAPNRFVLDW VRDKYINIIN 70 80 90 100 110 120 QFFTEQMGSN APKLRFDIGS RPSARPVAPA PVAAKPVNRQ TKAQVGTTSF NTQAEPIINP 130 140 150 160 170 180 NHRSNINPTY QFDNFVEGKS NQLGKAAALQ VSENPGGAYN PLFLYGGTGL GKTHLLHAVG 190 200 210 220 230 240 NGIIKNNPNA KVVYMHSERF VQDMVKALQN NAIEEFKRYY RSVDALFIDD IQFFANKDRS 250 260 270 280 290 300 QEEFFHTFNA LLEGNHQIIL TSDRYPKEID GVEDRLKSRF GWGLTVAIEP PELETRVAIL 310 320 330 340 350 360 MRKAQESGIN LPDEVAFFIA KRLRSNVREL EGALNRVIAN ANFTGRPITI DFVREALRDL 370 380 390 400 410 420 LALQEKLVTI DNIQKTVAEY YKIKMADMLS KRRSRSVARP RQVAMALSKE LTNQSLPEIG 430 440 450 460 DAFGGRDHTT VLHACRKIAQ LREESHDIKE DYANLIRTLS S

References

[1]

"Complete sequence of Shewanella frigidimarina NCIMB 400." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H., Newman D., Tiedje J.M. , Zhou J., Romine M.F., Culley D.E., Serres M., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCIMB 400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000447 Genomic DNA. Translation: ABI69864.1.
RefSeq	YP_748702.1. NC_008345.1.
3D structure databases
ProteinModelPortal	Q08A51.
SMR	Q08A51. Positions 2-85, 368-461.
ModBase	Search...
Protein-protein interaction databases
STRING	Q08A51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4277684.
GenomeReviews	Gene locus Sfri_0001 in contig CP000447_GR.
KEGG	sfr:Sfri_0001.
NMPDR	fig|318167.10.peg.1.
PATRIC	23493709. VBISheFri14343_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	DEVAFLI.
PhylomeDB	Q08A51.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_SHEFN

Accession

Primary (citable) accession number: Q08A51

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program