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Q089K8

- ASSY_SHEFN

UniProt

Q089K8 - ASSY_SHEFN

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Protein
Argininosuccinate synthase
Gene
argG, Sfri_0194
Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei96 – 961Citrulline By similarity
Binding sitei101 – 1011Citrulline By similarity
Binding sitei126 – 1261ATP; via amide nitrogen By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei132 – 1321Aspartate By similarity
Binding sitei132 – 1321Citrulline By similarity
Binding sitei133 – 1331Aspartate By similarity
Binding sitei136 – 1361Citrulline By similarity
Binding sitei185 – 1851Citrulline By similarity
Binding sitei194 – 1941Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity
Binding sitei282 – 2821Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-210-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Sfri_0194
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthaseUniRule annotation
PRO_0000263970Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_0194.

Structurei

3D structure databases

ProteinModelPortaliQ089K8.
SMRiQ089K8. Positions 12-407.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q089K8-1 [UniParc]FASTAAdd to Basket

« Hide

MSNAVKKTGV KKVVLAYSGG LDTSAIIPWL KETYDDCEII AFCADVGQGE    50
EELVGLTEKA LASGASECHI VDLKEEFVAD YIYPTIATGA IYEGTYLLGT 100
SMARPIIAKA QVEVARKVGA DAVCHGCTGK GNDQVRFEGC FAALAPDLKV 150
IAPWREWEMR SREDLLAYLA ERDIKTSASA TKIYSRDANA WHISHEGGEL 200
EDPWNEPSKG VWTLTVAPED APNEPEYVSL AVKHGRVTHV NDEALSPYAA 250
LMKLNDIAGK HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAGLRAIEEL 300
VLDKTSRTWR EQIAGQMSHL VYDGRWFTPL CKSLIAASES LAESVNGDVV 350
IKLYKGQATA VKKRSPNSLY SESFATFGED DVYDQKHAEG FIRLYSLASR 400
IRALNTK 407
Length:407
Mass (Da):44,566
Last modified:October 31, 2006 - v1
Checksum:iC6746BFC717F4912
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI70057.1.
RefSeqiWP_011635684.1. NC_008345.1.
YP_748895.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI70057; ABI70057; Sfri_0194.
GeneIDi4278120.
KEGGisfr:Sfri_0194.
PATRICi23494145. VBISheFri14343_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI70057.1 .
RefSeqi WP_011635684.1. NC_008345.1.
YP_748895.1. NC_008345.1.

3D structure databases

ProteinModelPortali Q089K8.
SMRi Q089K8. Positions 12-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318167.Sfri_0194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI70057 ; ABI70057 ; Sfri_0194 .
GeneIDi 4278120.
KEGGi sfr:Sfri_0194.
PATRICi 23494145. VBISheFri14343_0203.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SFRI318167:GIXS-210-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiASSY_SHEFN
AccessioniPrimary (citable) accession number: Q089K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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