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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (Sfri_1275)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-277-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:Sfri_0261
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000684 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Glycerol-3-phosphate acyltransferasePRO_1000049457Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318167.Sfri_0261.

Structurei

3D structure databases

ProteinModelPortaliQ089E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi308 – 3136HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q089E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPDSIFLR ALRWIQKWMV QTIVVPHDPF DDLNIDPTKP LVYLMKTESI
60 70 80 90 100
SDIAALSEIT EGFGLPSPYE PLQLDGLTVP RVVCLEGRKP LFGKRESGDK
110 120 130 140 150
FLNYFTSLLS LHSESPELDI QLVPVCLYWG RTPGKEEDSM KAAVFERENP
160 170 180 190 200
TWLRKWLMIL FLGRHNFVQF SNALSLRHMA DEHGTDKRIA HKLTRVARVH
210 220 230 240 250
FRRQRKVMTG PQLPNRQALF ASLLKSESIK KAIEEESANK KVTVEKARET
260 270 280 290 300
AIEYLDEIAA DYSDSLVRIA ERFLTWLWNK LYSGINIKGA EQVRQLHHDG
310 320 330 340 350
HEIVYVPCHR SHMDYLLLSY ILYYQGMVPP HIAAGINLNF WPAGPMFRRG
360 370 380 390 400
GAFFIRRSFN GNKLYTAVFR EYLDQLFAKG YAVEYFTEGG RSRTGRLLAP
410 420 430 440 450
KTGMLAMTIN SVLRGIERPV TLVPVYLGYD HVMEVATYHK ELSGKKKKKE
460 470 480 490 500
SVWQVFGAIR KLGNFGQGYV NFGEPINLQQ FLNQQAPEWR DELAKDPDQK
510 520 530 540 550
PSWFTPSVNL LANRVMTNIN GAAAASSVTL TSLVLLASEQ NALERSQLER
560 570 580 590 600
QLDLYLALLK TVPYTEYASV AEGNGKSIVD HCLSLNKFVS TKDLIGEIIS
610 620 630 640 650
VDEKIAITMS YYRNNIIHLM ALPSLIASCL VHYDVCDRQR IHAIVMDFYP
660 670 680 690 700
LLKAELFMSI DDVPKHVDCI LDFMVEQGLL TGSDQFEITP RHITQVLLLA
710 720 730 740 750
ETISETLQRY AIIFNLLAIK PDLERSELER DSHLLAQRLG ALHGITAPEF
760 770 780 790 800
YDKKLYNTLS VKLKELGYLC SDEHRAEVIR IRDNANKLLS SLVRQTIVDS

VEAEHGQ
Length:807
Mass (Da):91,990
Last modified:October 31, 2006 - v1
Checksum:iF3AAA95E1FBB6CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI70124.1.
RefSeqiWP_011635751.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI70124; ABI70124; Sfri_0261.
KEGGisfr:Sfri_0261.
PATRICi23494285. VBISheFri14343_0273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI70124.1.
RefSeqiWP_011635751.1. NC_008345.1.

3D structure databases

ProteinModelPortaliQ089E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318167.Sfri_0261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI70124; ABI70124; Sfri_0261.
KEGGisfr:Sfri_0261.
PATRICi23494285. VBISheFri14343_0273.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciSFRI318167:GIXS-277-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_SHEFN
AccessioniPrimary (citable) accession number: Q089E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.