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Protein

S-adenosylmethionine permease SAM3

Gene

SAM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • putrescine transmembrane transporter activity Source: SGD
  • S-adenosyl-L-methionine transmembrane transporter activity Source: SGD
  • spermidine transmembrane transporter activity Source: SGD

GO - Biological processi

  • putrescine transport Source: SGD
  • S-adenosyl-L-methionine transport Source: SGD
  • spermidine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34155-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.15. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine permease SAM3
Alternative name(s):
S-adenosylmethionine metabolism protein 3
Gene namesi
Name:SAM3
Ordered Locus Names:YPL274W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL274W.
SGDiS000006195. SAM3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8080CytoplasmicSequence analysisAdd
BLAST
Transmembranei81 – 10323HelicalSequence analysisAdd
BLAST
Topological domaini104 – 1096ExtracellularSequence analysis
Transmembranei110 – 12920HelicalSequence analysisAdd
BLAST
Topological domaini130 – 16233CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 1863ExtracellularSequence analysis
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Topological domaini208 – 21912CytoplasmicSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Topological domaini241 – 26626ExtracellularSequence analysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST
Topological domaini288 – 30215CytoplasmicSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Topological domaini324 – 36037ExtracellularSequence analysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Topological domaini382 – 40625CytoplasmicSequence analysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence analysisAdd
BLAST
Topological domaini428 – 4314ExtracellularSequence analysis
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST
Topological domaini453 – 47523CytoplasmicSequence analysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence analysisAdd
BLAST
Topological domaini497 – 50913ExtracellularSequence analysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence analysisAdd
BLAST
Topological domaini531 – 58757CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587S-adenosylmethionine permease SAM3PRO_0000054163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineCombined sources
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei44 – 441PhosphoserineCombined sources
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ08986.

PTM databases

iPTMnetiQ08986.
SwissPalmiQ08986.

Interactioni

Protein-protein interaction databases

BioGridi35939. 49 interactions.
DIPiDIP-8874N.
MINTiMINT-4505753.

Structurei

3D structure databases

ProteinModelPortaliQ08986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiQ08986.
KOiK16261.
OMAiCLSIPIM.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDILKRGNES DKFTKIETES TTIPNDSDRS GSLIRRMKDS FKQSNLHVIP
60 70 80 90 100
EDLENSEQTE QEKIQWKLAS QPYQKVLSQR HLTMIAIGGT LGTGLFIGLG
110 120 130 140 150
YSLASGPAAL LIGFLLVGTS MFCVVQSAAE LSCQFPVSGS YATHVSRFID
160 170 180 190 200
ESVGFTVATN YALAWLISFP SELIGCALTI SYWNQTVNPA VWVAIFYVFI
210 220 230 240 250
MVLNLFGVRG FAETEFALSI IKVIAIFIFI IIGIVLIAGG GPNSTGYIGA
260 270 280 290 300
KYWHDPGAFA KPVFKNLCNT FVSAAFSFGG SELVLLTSTE SKNISAISRA
310 320 330 340 350
AKGTFWRIAI FYITTVVIIG CLVPYNDPRL LSGSNSEDVS ASPFVIALSN
360 370 380 390 400
TGSMGAKVSN FMNVVILVAV VSVCNSCVYA SSRLIQALGA SGQLPSVCSY
410 420 430 440 450
MDRKGRPLVG IGISGAFGLL GFLVASKKED EVFTWLFALC SISSFFTWFC
460 470 480 490 500
ICMSQIRFRM ALKAQGRSND EIAYKSILGV YGGILGCVLN ALLIAGEIYV
510 520 530 540 550
SAAPVGSPSS AEAFFEYCLS IPIMIVVYFA HRFYRRDWKH FYIKRSEIDL
560 570 580
DTGCSVENLE LFKAQKEAEE QLIASKPFYY KIYRFWC
Length:587
Mass (Da):64,354
Last modified:November 1, 1996 - v1
Checksum:i6ADEA30F9763B92F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73629 Genomic DNA. Translation: CAA98010.1.
Z73630 Genomic DNA. Translation: CAA98011.1.
BK006949 Genomic DNA. Translation: DAA11162.1.
PIRiS65307.
RefSeqiNP_015049.1. NM_001184088.1.

Genome annotation databases

EnsemblFungiiYPL274W; YPL274W; YPL274W.
GeneIDi855854.
KEGGisce:YPL274W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73629 Genomic DNA. Translation: CAA98010.1.
Z73630 Genomic DNA. Translation: CAA98011.1.
BK006949 Genomic DNA. Translation: DAA11162.1.
PIRiS65307.
RefSeqiNP_015049.1. NM_001184088.1.

3D structure databases

ProteinModelPortaliQ08986.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35939. 49 interactions.
DIPiDIP-8874N.
MINTiMINT-4505753.

Protein family/group databases

TCDBi2.A.3.10.15. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ08986.
SwissPalmiQ08986.

Proteomic databases

MaxQBiQ08986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL274W; YPL274W; YPL274W.
GeneIDi855854.
KEGGisce:YPL274W.

Organism-specific databases

EuPathDBiFungiDB:YPL274W.
SGDiS000006195. SAM3.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiQ08986.
KOiK16261.
OMAiCLSIPIM.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-34155-MONOMER.

Miscellaneous databases

PROiQ08986.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAM3_YEAST
AccessioniPrimary (citable) accession number: Q08986
Secondary accession number(s): D6W396, Q7LGU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.