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Protein

APC/C-CDH1 modulator 1

Gene

ACM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.1 Publication

GO - Molecular functioni

  • ubiquitin-protein transferase inhibitor activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
APC/C-CDH1 modulator 1
Gene namesi
Name:ACM1
Ordered Locus Names:YPL267W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL267W.
SGDiS000006188. ACM1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209APC/C-CDH1 modulator 1PRO_0000268174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481PhosphoserineCombined sources
Modified residuei161 – 1611PhosphothreonineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiQ08981.

Expressioni

Inductioni

Expressed very quickly after G1 release, just prior to initiation of DNA replication.1 Publication

Interactioni

Subunit structurei

Interacts with CDH1, BMH1 and BMH2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDH1P531978EBI-2345174,EBI-23684

Protein-protein interaction databases

BioGridi35946. 22 interactions.
DIPiDIP-8871N.
IntActiQ08981. 6 interactions.
MINTiMINT-6490640.

Structurei

Secondary structure

1
209
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi68 – 8417Combined sources
Helixi95 – 1006Combined sources
Helixi103 – 1064Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BH6X-ray2.90I/J/K/L/M/N/O/P59-128[»]
ProteinModelPortaliQ08981.
SMRiQ08981. Positions 60-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000033782.
InParanoidiQ08981.
OMAiHETHVND.
OrthoDBiEOG092C5CYT.

Sequencei

Sequence statusi: Complete.

Q08981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPSKKRTI LSSKNINQKP RAVVKGNELR SPSKRRSQID TDYALRRSPI
60 70 80 90 100
KTIQISKAAQ FMLYEETAEE RNIAVHRHNE IYNNNNSVSN ENNPSQVKEN
110 120 130 140 150
LSPAKICPYE RAFLREGGRI ALKDLSVDEF KGYIQDPLTD ETIPLTLPLG
160 170 180 190 200
DKKISLPSFI TPPRNSKISI FFTSKHQGQN PETKISRSTD DVSEKKVVRK

LSFHVYEDE
Length:209
Mass (Da):23,870
Last modified:November 1, 1996 - v1
Checksum:i0646D4E3AD41758C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73623 Genomic DNA. Translation: CAA98002.1.
AY558139 Genomic DNA. Translation: AAS56465.1.
BK006949 Genomic DNA. Translation: DAA11169.1.
PIRiS65300.
RefSeqiNP_015056.1. NM_001184081.1.

Genome annotation databases

EnsemblFungiiYPL267W; YPL267W; YPL267W.
GeneIDi855861.
KEGGisce:YPL267W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73623 Genomic DNA. Translation: CAA98002.1.
AY558139 Genomic DNA. Translation: AAS56465.1.
BK006949 Genomic DNA. Translation: DAA11169.1.
PIRiS65300.
RefSeqiNP_015056.1. NM_001184081.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BH6X-ray2.90I/J/K/L/M/N/O/P59-128[»]
ProteinModelPortaliQ08981.
SMRiQ08981. Positions 60-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35946. 22 interactions.
DIPiDIP-8871N.
IntActiQ08981. 6 interactions.
MINTiMINT-6490640.

PTM databases

iPTMnetiQ08981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL267W; YPL267W; YPL267W.
GeneIDi855861.
KEGGisce:YPL267W.

Organism-specific databases

EuPathDBiFungiDB:YPL267W.
SGDiS000006188. ACM1.

Phylogenomic databases

HOGENOMiHOG000033782.
InParanoidiQ08981.
OMAiHETHVND.
OrthoDBiEOG092C5CYT.

Enzyme and pathway databases

BioCyciYEAST:G3O-34150-MONOMER.

Miscellaneous databases

PROiQ08981.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiACM1_YEAST
AccessioniPrimary (citable) accession number: Q08981
Secondary accession number(s): D6W3A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 688 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.