Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial metal transporter 2

Gene

MMT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial metal transporter involved in mitochondrial iron accumulation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron storage, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-34113-MONOMER.

Protein family/group databases

TCDBi2.A.4.1.6. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial metal transporter 2
Gene namesi
Name:MMT2
Synonyms:MFT2
Ordered Locus Names:YPL224C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL224C.
SGDiS000006145. MMT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: SGD
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656MitochondrionSequence analysisAdd
BLAST
Chaini57 – 484428Mitochondrial metal transporter 2PRO_0000255968Add
BLAST

Proteomic databases

MaxQBiQ08970.

Interactioni

Protein-protein interaction databases

BioGridi35961. 19 interactions.
DIPiDIP-3963N.
MINTiMINT-571416.

Structurei

3D structure databases

ProteinModelPortaliQ08970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009685.
HOGENOMiHOG000174851.
InParanoidiQ08970.
OMAiSADTHTH.
OrthoDBiEOG76QFTX.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRISIDSIK QFGSFVPGYN NTSYHAAGRA IRTSSLYSTM ISANPRRCLH
60 70 80 90 100
SSKLLNKEGQ EEGYNEQLIS KMSSQNGSNS RQNESEGKKE GKASSVKSLL
110 120 130 140 150
QHTHSHSHTH MHDNPLLSLN VQQIKKNPGV RITWIGLASN VGMAVGKFVG
160 170 180 190 200
GITFHSQALL ADSVHALSDL VSDFLTLFSV QYASRKPTSE YPYGYGKVET
210 220 230 240 250
VGSLAVSTIL AMAGISIGWS SLCAIVGPVI PHAILESMAG LIGETHSHSQ
260 270 280 290 300
SLTQQATNVN AVWIAAGSIL VKEWVFQATK KVAIQTNSNV LMANAWHHRV
310 320 330 340 350
DSLTSLVALV AITSSYFFNI QSLDNLGGLV VSGLIIKTGG QGILSSLKEL
360 370 380 390 400
VDQSIPPTDP RYLEIESVIK DSIGSLKTDL DLKQSLHVRD LTILASGPNL
410 420 430 440 450
RATTTLEVPV LHSGQEVGIR FLENAISTIR EDLRMKVPNV GKVDVEFVDV
460 470 480
TSDSKGDLEH SHDTKSTNHT HTHSDSADTH THKH
Length:484
Mass (Da):52,434
Last modified:September 21, 2011 - v2
Checksum:iF9BD946F38D10B31
GO

Sequence cautioni

The sequence CAA97939.1 differs from that shown. Reason: Frameshift at position 442. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171P → T in CAA97939 (PubMed:9169875).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73580 Genomic DNA. Translation: CAA97939.1. Frameshift.
BK006949 Genomic DNA. Translation: DAA11212.2.
PIRiS65243.
RefSeqiNP_015100.2. NM_001184038.2.

Genome annotation databases

EnsemblFungiiYPL224C; YPL224C; YPL224C.
GeneIDi855877.
KEGGisce:YPL224C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73580 Genomic DNA. Translation: CAA97939.1. Frameshift.
BK006949 Genomic DNA. Translation: DAA11212.2.
PIRiS65243.
RefSeqiNP_015100.2. NM_001184038.2.

3D structure databases

ProteinModelPortaliQ08970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35961. 19 interactions.
DIPiDIP-3963N.
MINTiMINT-571416.

Protein family/group databases

TCDBi2.A.4.1.6. the cation diffusion facilitator (cdf) family.

Proteomic databases

MaxQBiQ08970.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL224C; YPL224C; YPL224C.
GeneIDi855877.
KEGGisce:YPL224C.

Organism-specific databases

EuPathDBiFungiDB:YPL224C.
SGDiS000006145. MMT2.

Phylogenomic databases

GeneTreeiENSGT00390000009685.
HOGENOMiHOG000174851.
InParanoidiQ08970.
OMAiSADTHTH.
OrthoDBiEOG76QFTX.

Enzyme and pathway databases

BioCyciYEAST:G3O-34113-MONOMER.

Miscellaneous databases

PROiQ08970.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 17 AND 442.
    Strain: ATCC 204508 / S288c.
  3. "Characterization of two homologous yeast genes that encode mitochondrial iron transporters."
    Li L., Kaplan J.
    J. Biol. Chem. 272:28485-28493(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiMMT2_YEAST
AccessioniPrimary (citable) accession number: Q08970
Secondary accession number(s): D6W3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 21, 2011
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.