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Protein

Mitochondrial metal transporter 2

Gene

MMT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial metal transporter involved in mitochondrial iron accumulation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD

Keywordsi

Biological processIon transport, Iron storage, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciYEAST:G3O-34113-MONOMER

Protein family/group databases

TCDBi2.A.4.1.6 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial metal transporter 2
Gene namesi
Name:MMT2
Synonyms:MFT2
Ordered Locus Names:YPL224C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YPL224C
SGDiS000006145 MMT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 56MitochondrionSequence analysisAdd BLAST56
ChainiPRO_000025596857 – 484Mitochondrial metal transporter 2Add BLAST428

Proteomic databases

MaxQBiQ08970
PaxDbiQ08970
PRIDEiQ08970

Interactioni

Protein-protein interaction databases

BioGridi35961, 101 interactors
DIPiDIP-3963N
MINTiQ08970
STRINGi4932.YPL224C

Structurei

3D structure databases

ProteinModelPortaliQ08970
SMRiQ08970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009685
HOGENOMiHOG000174851
InParanoidiQ08970
OMAiGVYFHSQ
OrthoDBiEOG092C3QRH

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRISIDSIK QFGSFVPGYN NTSYHAAGRA IRTSSLYSTM ISANPRRCLH
60 70 80 90 100
SSKLLNKEGQ EEGYNEQLIS KMSSQNGSNS RQNESEGKKE GKASSVKSLL
110 120 130 140 150
QHTHSHSHTH MHDNPLLSLN VQQIKKNPGV RITWIGLASN VGMAVGKFVG
160 170 180 190 200
GITFHSQALL ADSVHALSDL VSDFLTLFSV QYASRKPTSE YPYGYGKVET
210 220 230 240 250
VGSLAVSTIL AMAGISIGWS SLCAIVGPVI PHAILESMAG LIGETHSHSQ
260 270 280 290 300
SLTQQATNVN AVWIAAGSIL VKEWVFQATK KVAIQTNSNV LMANAWHHRV
310 320 330 340 350
DSLTSLVALV AITSSYFFNI QSLDNLGGLV VSGLIIKTGG QGILSSLKEL
360 370 380 390 400
VDQSIPPTDP RYLEIESVIK DSIGSLKTDL DLKQSLHVRD LTILASGPNL
410 420 430 440 450
RATTTLEVPV LHSGQEVGIR FLENAISTIR EDLRMKVPNV GKVDVEFVDV
460 470 480
TSDSKGDLEH SHDTKSTNHT HTHSDSADTH THKH
Length:484
Mass (Da):52,434
Last modified:September 21, 2011 - v2
Checksum:iF9BD946F38D10B31
GO

Sequence cautioni

The sequence CAA97939 differs from that shown. Reason: Frameshift at position 442.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17P → T in CAA97939 (PubMed:9169875).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73580 Genomic DNA Translation: CAA97939.1 Frameshift.
BK006949 Genomic DNA Translation: DAA11212.2
PIRiS65243
RefSeqiNP_015100.2, NM_001184038.2

Genome annotation databases

EnsemblFungiiYPL224C; YPL224C; YPL224C
GeneIDi855877
KEGGisce:YPL224C

Similar proteinsi

Entry informationi

Entry nameiMMT2_YEAST
AccessioniPrimary (citable) accession number: Q08970
Secondary accession number(s): D6W3E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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