Q08968 (FMP40_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0061 protein FMP40

Gene names

Name:	FMP40
Ordered Locus Names:	YPL222W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	688 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Ref.3 Ref.5.
Induction	Expression is regulated by zinc levels. Ref.6
Miscellaneous	Present with 2430 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the UPF0061 (SELO) family.

Ontologies

Keywords
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay Ref.3Ref.5. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRP40	P33203	2	EBI-29375,EBI-701

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 688	688	UPF0061 protein FMP40		PRO_0000121401

Sequences

	Sequence		Length	Mass (Da)
	Q08968 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7C56CD503ED24B1E	FASTA	688	78,313
	10 20 30 40 50 60 MGEKRTIIKA LKNSAASHFI KKLTADTSLS SIQEAINVVQ QYNATDPVRL KLFHTPRMVS 70 80 90 100 110 120 QGAHFAFCLP TKKPHYKPLL LSQNALDEFN LVQDQDLEKI LSGEKVYYSD SIFPYSTVYS 130 140 150 160 170 180 GFQFGSFAAQ LGDGRVVNLF DLKDKCSGQW QTFQLKGAGM TPFSRFADGK AVLRSSIREF 190 200 210 220 230 240 IMSEALHSIG IPSTRAMQLT LLPGTKAQRR NQEPCAVVCR FAPSWIRLGN FNLFRWRHDL 250 260 270 280 290 300 KGLIQLSDYC IEELFAGGTQ FEGKPDFNIF KRDFFPDTET KIDEQVEKDE TEVSTMTGDN 310 320 330 340 350 360 ISTLSKYDEF FRHVVSLNAN TVAHWQAYGF ANGVLNTDNT SIMGLTIDYG PFAFLDKFEP 370 380 390 400 410 420 SFTPNHDDTA KRYSFANQPS IIWWNLQQFA KDLACLLGPE ARDLELLLKG ELNSVDDALE 430 440 450 460 470 480 KTMIERVQKL VELSANEYKY VFTTRYAQIM SQRLGVDLDL EKCMSSTNLK DIEHAAEKAK 490 500 510 520 530 540 EFCDVIVEPL LDILQATKVD YNNFFIHLQN YKGPFFIKDK SDTATLFGAF DEEYLGMFFN 550 560 570 580 590 600 SKQLQQMAET EEAFAAGEKV FDANGELRLL NEKLQEIRNW TQDYLTLVPP TETAARASLA 610 620 630 640 650 660 KKANPLFVPR SWVLEEVVDD LMYSQRDGLQ DPSSELDTSA LKKLYLMSVN PYDRTKWDVT 670 680 LRPELETKWA DLSHQDDAKF MMQASCSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
[6]	"Acetaldehyde addition throughout the growth phase alleviates the phenotypic effect of zinc deficiency in Saccharomyces cerevisiae." Cheraiti N., Sauvage F.-X., Salmon J.-M. Appl. Microbiol. Biotechnol. 77:1093-1109(2008) [PubMed: 17938904] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73578 Genomic DNA. Translation: CAA97937.1. BK006949 Genomic DNA. Translation: DAA11214.1.
PIR	S65241.
RefSeq	NP_015102.1. NM_001184036.1.
3D structure databases
ProteinModelPortal	Q08968.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2001N.
IntAct	Q08968. 6 interactions.
MINT	MINT-393256.
STRING	Q08968.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPL222W; YPL222W; YPL222W.
GeneID	855879.
KEGG	sce:YPL222W.
NMPDR	fig|4932.3.peg.6229.
Organism-specific databases
CYGD	YPL222w.
SGD	S000006143. FMP40.
Phylogenomic databases
eggNOG	fuNOG06676.
GeneTree	EFGT00050000005006.
HOGENOM	HBG683993.
OMA	NAECVAY.
OrthoDB	EOG4H49C9.
Gene expression databases
ArrayExpress	Q08968.
Genevestigator	Q08968.
GermOnline	YPL222W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003846. UPF0061. [Graphical view]
PANTHER	PTHR12153. PTHR12153. 1 hit.
Pfam	PF02696. UPF0061. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	980529.

Entry information

Entry name

FMP40_YEAST

Accession

Primary (citable) accession number: Q08968
Secondary accession number(s): D6W3E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program