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Protein

Flavin carrier protein 1

Gene

FLC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.1 Publication

GO - Molecular functioni

  • FAD transmembrane transporter activity Source: SGD

GO - Biological processi

  • FAD transport Source: SGD
  • fungal-type cell wall biogenesis Source: SGD
  • protein folding Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34110-MONOMER.

Protein family/group databases

TCDBi1.A.4.9.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flavin carrier protein 1
Alternative name(s):
Bypass of PAM1 protein 1
FAD transporter 1
Heme utilization factor 1
TRP-like ion channel protein FLC1
Gene namesi
Name:FLC1
Synonyms:BOP1, HUF1
Ordered Locus Names:YPL221W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL221W.
SGDiS000006142. FLC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 163LumenalSequence analysisAdd BLAST142
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 194CytoplasmicSequence analysis10
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 223LumenalSequence analysis8
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 249CytoplasmicSequence analysis5
Transmembranei250 – 272HelicalSequence analysisAdd BLAST23
Topological domaini273 – 317LumenalSequence analysisAdd BLAST45
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 372CytoplasmicSequence analysisAdd BLAST34
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 397LumenalSequence analysis4
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 461CytoplasmicSequence analysisAdd BLAST43
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 484LumenalSequence analysis2
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 516CytoplasmicSequence analysisAdd BLAST11
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 551LumenalSequence analysisAdd BLAST14
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21
Topological domaini573 – 793CytoplasmicSequence analysisAdd BLAST221

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000025226722 – 793Flavin carrier protein 1Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Modified residuei610PhosphoserineBy similarity1
Modified residuei626PhosphothreonineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ08967.
PRIDEiQ08967.

PTM databases

iPTMnetiQ08967.

Interactioni

Protein-protein interaction databases

BioGridi35964. 38 interactors.
DIPiDIP-3965N.
IntActiQ08967. 22 interactors.
MINTiMINT-523610.

Structurei

3D structure databases

ProteinModelPortaliQ08967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065299.
HOGENOMiHOG000168830.
InParanoidiQ08967.
OMAiFVAIIRY.
OrthoDBiEOG092C186V.

Family and domain databases

InterProiIPR010308. TRP-like_family.
IPR032800. TRP_N.
[Graphical view]
PfamiPF06011. TRP. 1 hit.
PF14558. TRP_N. 1 hit.
[Graphical view]
SMARTiSM01320. TRP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLVTLWCL ICTCLVLPVA AKKRTLTASS LVTCMENSQL SANSFDVSFS
60 70 80 90 100
PDDRSLHYDL DMTTQIDSYI YAYVDVYAYG FKIITENFDV CSMGWKQFCP
110 120 130 140 150
VHPGNIQIDS IEYIAQKYVK MIPGIAYQVP DIDAYVRLNI YNNVSENLAC
160 170 180 190 200
IQVFFSNGKT VSQIGVKWVT AVIAGIGLLT SAVLSTFGNS TAASHISANT
210 220 230 240 250
MSLFLYFQSV AVVAMQHVDS VPPIAAAWSE NLAWSMGLIR ITFMQKIFRW
260 270 280 290 300
YVEATGGSAS LYLTATTMSV LTQRGLDYLK NTSVYKRAEN VLYGNSNTLI
310 320 330 340 350
FRGIKRMGYR MKIENTAIVC TGFTFFVLCG YFLAGFIMAC KYSIELCIRC
360 370 380 390 400
GWMRSDRFYQ FRKNWRSVLK GSLLRYIYIG FTQLTILSFW EFTERDSAGV
410 420 430 440 450
IVIACLFIVL SCGLMAWAAY RTIFFASKSV EMYNNPAALL YGDEYVLNKY
460 470 480 490 500
GFFYTMFNAK HYWWNALLTT YILVKALFVG FAQASGKTQA LAIFIIDLAY
510 520 530 540 550
FVAIIRYKPY LDRPTNIVNI FICTVTLVNS FLFMFFSNLF NQKYAVSAIM
560 570 580 590 600
GWVFFIMNAA FSLLLLLMIL AFTTIILFSK NPDSRFKPAK DDRASFQKHA
610 620 630 640 650
IPHEGALNKS VANELMALGN VAKDHTENWE YELKSQEGKS EDNLFGVEYD
660 670 680 690 700
DEKTGTNSEN AESSSKETTR PTFSEKVLRS LSIKRNKSKL GSFKRSAPDK
710 720 730 740 750
ITQQEVSPDR ASSSPNSKSY PGVSHTRQES EANNGLINAY EDEQFSLMEP
760 770 780 790
SILEDAASST QMHAMPARDL SLSSVANAQD VTKKANILDP DYL
Length:793
Mass (Da):89,291
Last modified:November 1, 1996 - v1
Checksum:iFAB678C0038E2604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73577 Genomic DNA. Translation: CAA97936.1.
BK006949 Genomic DNA. Translation: DAA11215.1.
PIRiS65240.
RefSeqiNP_015103.1. NM_001184035.1.

Genome annotation databases

EnsemblFungiiYPL221W; YPL221W; YPL221W.
GeneIDi855880.
KEGGisce:YPL221W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73577 Genomic DNA. Translation: CAA97936.1.
BK006949 Genomic DNA. Translation: DAA11215.1.
PIRiS65240.
RefSeqiNP_015103.1. NM_001184035.1.

3D structure databases

ProteinModelPortaliQ08967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35964. 38 interactors.
DIPiDIP-3965N.
IntActiQ08967. 22 interactors.
MINTiMINT-523610.

Protein family/group databases

TCDBi1.A.4.9.1. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ08967.

Proteomic databases

MaxQBiQ08967.
PRIDEiQ08967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL221W; YPL221W; YPL221W.
GeneIDi855880.
KEGGisce:YPL221W.

Organism-specific databases

EuPathDBiFungiDB:YPL221W.
SGDiS000006142. FLC1.

Phylogenomic databases

GeneTreeiENSGT00530000065299.
HOGENOMiHOG000168830.
InParanoidiQ08967.
OMAiFVAIIRY.
OrthoDBiEOG092C186V.

Enzyme and pathway databases

BioCyciYEAST:G3O-34110-MONOMER.

Miscellaneous databases

PROiQ08967.

Family and domain databases

InterProiIPR010308. TRP-like_family.
IPR032800. TRP_N.
[Graphical view]
PfamiPF06011. TRP. 1 hit.
PF14558. TRP_N. 1 hit.
[Graphical view]
SMARTiSM01320. TRP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLC1_YEAST
AccessioniPrimary (citable) accession number: Q08967
Secondary accession number(s): D6W3E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.