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Protein

60S ribosome subunit biogenesis protein NIP7

Gene

NIP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.

GO - Molecular functioni

GO - Biological processi

  • assembly of large subunit precursor of preribosome Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • ribosomal large subunit biogenesis Source: SGD
  • ribosome assembly Source: InterPro

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-34102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7
Alternative name(s):
Nuclear import protein 7
Gene namesi
Name:NIP7
Ordered Locus Names:YPL211W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL211W.
SGDiS000006132. NIP7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosol Source: EnsemblPlants
  • nucleolus Source: UniProtKB-SubCell
  • nucleus Source: SGD
  • preribosome, large subunit precursor Source: SGD

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161 – 164IVAF → AVAA: Reduces RNA-binding ability in vitro. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187761 – 18160S ribosome subunit biogenesis protein NIP7Add BLAST181

Proteomic databases

MaxQBiQ08962.
PRIDEiQ08962.

PTM databases

iPTMnetiQ08962.

Interactioni

Subunit structurei

Interacts with NOP8 and RRP43. Interacts with pre-ribosome complex. May bind to RNA.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35974. 332 interactors.
DIPiDIP-1456N.
IntActiQ08962. 46 interactors.
MINTiMINT-400883.

Structurei

3D structure databases

ProteinModelPortaliQ08962.
SMRiQ08962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170PUAPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the NIP7 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
InParanoidiQ08962.
KOiK07565.
OMAiVVKAHVG.
OrthoDBiEOG09264PD5.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
PfamiView protein in Pfam
PF03657. UPF0113. 1 hit.
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLTEEETK VVFEKLAGYI GRNISFLVDN KELPHVFRLQ KDRVYYVPDH
60 70 80 90 100
VAKLATSVAR PNLMSLGICL GKFTKTGKFR LHITSLTVLA KHAKYKIWIK
110 120 130 140 150
PNGEMPFLYG NHVLKAHVGK MSDDIPEHAG VIVFAMNDVP LGFGVSAKST
160 170 180
SESRNMQPTG IVAFRQADIG EYLRDEDTLF T
Length:181
Mass (Da):20,381
Last modified:November 1, 1996 - v1
Checksum:i82EAE8E4B2FCC31A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73567 Genomic DNA. Translation: CAA97926.1.
AY558059 Genomic DNA. Translation: AAS56385.1.
BK006949 Genomic DNA. Translation: DAA11225.1.
PIRiS65230.
RefSeqiNP_015113.1. NM_001184025.1.

Genome annotation databases

EnsemblFungiiYPL211W; YPL211W; YPL211W.
GeneIDi855890.
KEGGisce:YPL211W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73567 Genomic DNA. Translation: CAA97926.1.
AY558059 Genomic DNA. Translation: AAS56385.1.
BK006949 Genomic DNA. Translation: DAA11225.1.
PIRiS65230.
RefSeqiNP_015113.1. NM_001184025.1.

3D structure databases

ProteinModelPortaliQ08962.
SMRiQ08962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35974. 332 interactors.
DIPiDIP-1456N.
IntActiQ08962. 46 interactors.
MINTiMINT-400883.

PTM databases

iPTMnetiQ08962.

Proteomic databases

MaxQBiQ08962.
PRIDEiQ08962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL211W; YPL211W; YPL211W.
GeneIDi855890.
KEGGisce:YPL211W.

Organism-specific databases

EuPathDBiFungiDB:YPL211W.
SGDiS000006132. NIP7.

Phylogenomic databases

GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
InParanoidiQ08962.
KOiK07565.
OMAiVVKAHVG.
OrthoDBiEOG09264PD5.

Enzyme and pathway databases

BioCyciYEAST:G3O-34102-MONOMER.

Miscellaneous databases

PROiQ08962.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
PfamiView protein in Pfam
PF03657. UPF0113. 1 hit.
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIP7_YEAST
AccessioniPrimary (citable) accession number: Q08962
Secondary accession number(s): D6W3F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5170 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.