Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iron-regulated transcriptional activator AFT2

Gene

AFT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.5 Publications

GO - Molecular functioni

GO - Biological processi

  • cardiolipin metabolic process Source: SGD
  • cellular iron ion homeostasis Source: SGD
  • cellular response to oxidative stress Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-34094-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated transcriptional activator AFT2
Alternative name(s):
Activator of iron transcription protein 2
Gene namesi
Name:AFT2
Ordered Locus Names:YPL202C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL202C.
SGDiS000006123. AFT2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275991 – 416Iron-regulated transcriptional activator AFT2Add BLAST416

Proteomic databases

MaxQBiQ08957.
PRIDEiQ08957.

Interactioni

Protein-protein interaction databases

BioGridi35982. 28 interactors.
MINTiMINT-596804.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi54 – 56Combined sources3
Helixi57 – 65Combined sources9
Helixi66 – 68Combined sources3
Beta strandi72 – 78Combined sources7
Beta strandi81 – 86Combined sources6
Beta strandi112 – 118Combined sources7
Turni119 – 122Combined sources4
Beta strandi123 – 129Combined sources7
Helixi139 – 142Combined sources4
Helixi146 – 157Combined sources12
Helixi161 – 175Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LMGX-ray2.20A/B/C/D38-193[»]
ProteinModelPortaliQ08957.
SMRiQ08957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000069471.
InParanoidiQ08957.
OrthoDBiEOG092C52YQ.

Family and domain databases

InterProiIPR014842. AFT.
[Graphical view]
PfamiPF08731. AFT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKSMKSII SVPISVSKTG KMKLTASPDN LASMMSKDQN KLIHLDPVPS
60 70 80 90 100
FEDRHEIKPW LQKIFYPQGI DIVIERSDSS KVTFKCRSVR SKVGLNPKSK
110 120 130 140 150
GSSSRSHACP FRIRAAYSVR LQKWNVVVMN NIHSHELRFD LITKTDDYKK
160 170 180 190 200
FKENLRQKND EKAIKTFDEL EYKASLNLPL VTPIISCDCG LTKEIEAFNN
210 220 230 240 250
IFLPLSNPPL TSKKNLLKTN KNSVSKIKSR QMDNSKPRPR LKTKLDADLH
260 270 280 290 300
DTGFLDNFKT RNSCVKIEKE DSLTNLNEID FTNMFCNDNF IQNYNQGLME
310 320 330 340 350
LLTEPTPGPS SSSCILPSTP TRPLSQSKMD IALSESTTSS PNFMETDAPY
360 370 380 390 400
GDEIIKVSKD TKSNAPTADT DIATNLGKER NENFGMLNYN YEALLHFNDE
410
HFNELNSIDP ALISKY
Length:416
Mass (Da):47,105
Last modified:November 1, 1996 - v1
Checksum:i0DAC56291EE56EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73558 Genomic DNA. Translation: CAA97916.1.
BK006949 Genomic DNA. Translation: DAA11233.1.
PIRiS65221.
RefSeqiNP_015122.1. NM_001184016.1.

Genome annotation databases

EnsemblFungiiYPL202C; YPL202C; YPL202C.
GeneIDi855899.
KEGGisce:YPL202C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73558 Genomic DNA. Translation: CAA97916.1.
BK006949 Genomic DNA. Translation: DAA11233.1.
PIRiS65221.
RefSeqiNP_015122.1. NM_001184016.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LMGX-ray2.20A/B/C/D38-193[»]
ProteinModelPortaliQ08957.
SMRiQ08957.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35982. 28 interactors.
MINTiMINT-596804.

Proteomic databases

MaxQBiQ08957.
PRIDEiQ08957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL202C; YPL202C; YPL202C.
GeneIDi855899.
KEGGisce:YPL202C.

Organism-specific databases

EuPathDBiFungiDB:YPL202C.
SGDiS000006123. AFT2.

Phylogenomic databases

GeneTreeiENSGT00530000069471.
InParanoidiQ08957.
OrthoDBiEOG092C52YQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-34094-MONOMER.

Miscellaneous databases

PROiQ08957.

Family and domain databases

InterProiIPR014842. AFT.
[Graphical view]
PfamiPF08731. AFT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAFT2_YEAST
AccessioniPrimary (citable) accession number: Q08957
Secondary accession number(s): D6W3G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transcription activation by RCS1 and AST2 depends on the mitochondrial iron-sulfur protein biosynthesis pathway.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.