Reviewed, UniProtKB/Swiss-Prot Q08926 (UIP4_YEAST)

Names and origin

Protein names

Recommended name:
    ULP1-interacting protein 4

Gene names

Name:	UIP4
Ordered Locus Names:	YPL186C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with ULP1. Ref.2
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion outer membrane. Nucleus envelope.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Mitochondrion Mitochondrion outer membrane Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Ref.2 Inferred from direct assay. Source: SGD extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial outer membrane Ref.3 Inferred from direct assay. Source: SGD nuclear envelope Ref.2 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P38756	1	EBI-2044051,EBI-24431
AGP1	P25376	1	EBI-2044051,EBI-2357
ALO1	P54783	1	EBI-2044051,EBI-2519
ERP1	Q05359	1	EBI-2044051,EBI-6581
ERV25	P54837	1	EBI-2044051,EBI-6642
FUN14	P18411	1	EBI-2044051,EBI-20609
OST1	P41543	1	EBI-2044051,EBI-12651
PEX11	Q12462	1	EBI-2044051,EBI-13198
PMP2	P40975	1	EBI-2044051,EBI-2043041
PMP3	P87284	1	EBI-2044051,EBI-13555
SPF1	P39986	1	EBI-2044051,EBI-3128
SWP1	Q02795	1	EBI-2044051,EBI-12666
YBL039W-B	P0C268	1	EBI-2044051,EBI-2044092

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	ULP1-interacting protein 4		PRO_0000270927
Amino acid modifications
	Modified residue	140	1	Phosphoserine Ref.4 Ref.5
	Modified residue	185	1	Phosphoserine Ref.4 Ref.5
	Modified residue	205	1	Phosphoserine Ref.4 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q08926-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C46486ABE0073A61	FASTA	304	34,222
	10 20 30 40 50 60 MVTIVFDHPA EDFPELKIAG EFTNWEGVPM KINTSSGKWE YKFDESSVTK HNDKDKVHFK 70 80 90 100 110 120 FIDQNGNWFA DDEYPKEVDE HSNENNVATL NNEEDGGSAG EEKDEGDKTA HNTNENGSEL 130 140 150 160 170 180 YYEGPETPTP SLKGNVTFPS PKTAISQDGS AFAKETTRKE RKYEHAPLNE VPVERDPKEE 190 200 210 220 230 240 NKELSPNFSQ EQTENKQDKG LDNLSEGNDN DNTRVNEDTD VTDTQESEHE INGSDTENTD 250 260 270 280 290 300 MSEQEEIQKI DKPADQNAKS IVKEGDANTE DYESVLKKLL GALGRFFGSW FSWLTTKMSS SEAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins." Takahashi Y., Mizoi J., Toh-e A., Kikuchi Y. J. Biochem. 128:723-725(2000) [PubMed: 11056382] [Abstract] Cited for: INTERACTION WITH ULP1.
[3]	"Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins." Zahedi R.P., Sickmann A., Boehm A.M., Winkler C., Zufall N., Schoenfisch B., Guiard B., Pfanner N., Meisinger C. Mol. Biol. Cell 17:1436-1450(2006) [PubMed: 16407407] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[4]	"Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C. Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed: 17761666] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-185 AND SER-205, MASS SPECTROMETRY.
[5]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-185 AND SER-205, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z73542 Genomic DNA. Translation: CAA97897.1.
PIR	S65198.
RefSeq	NP_015138.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q08926. 15 interactions.
STRING	Q08926.
Genome annotation databases
Ensembl	YPL186C; YPL186C; YPL186C; Saccharomyces cerevisiae. [Genome view]
GeneID	855916.
KEGG	sce:YPL186C.
NMPDR	fig|4932.3.peg.6267.
Organism-specific databases
CYGD	YPL186c.
SGD	S000006107. UIP4.
Phylogenomic databases
HOGENOM	Q08926.
OrthoDB	EOG97STX0
Gene expression databases
ArrayExpress	Q08926.
Genevestigator	Q08926.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	980631.

Entry information

Entry name

UIP4_YEAST

Accession

Primary (citable) accession number: Q08926

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)