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Protein

Regulator of Ty1 transposition protein 10

Gene

RTT10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of Ty1 transposition. Plays also a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Required together with TRM7 for the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)).3 Publications

Miscellaneous

Present with 3450 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • endocytic recycling Source: SGD
  • tRNA processing Source: UniProtKB-KW

Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-34077-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of Ty1 transposition protein 10
Alternative name(s):
Endosomal recycling protein 2
tRNA (guanosine(34)-2'-O)-methyltransferase non-catalytic subunit TRM734
Gene namesi
Name:RTT10
Synonyms:ERE2, TRM734
Ordered Locus Names:YPL183C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL183C.
SGDiS000006104. RTT10.

Subcellular locationi

  • Cytoplasm
  • Endosome

  • Note: Recruited to endosomes in cells in which increased recycling of internalized plasma membrane proteins occurs.

GO - Cellular componenti

  • cytoplasm Source: SGD
  • endosome Source: SGD

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Disruption phenotypei

Increases Ty1 mobility 31-fold.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343661 – 1013Regulator of Ty1 transposition protein 10Add BLAST1013

Proteomic databases

MaxQBiQ08924.
PRIDEiQ08924.

PTM databases

iPTMnetiQ08924.

Interactioni

Subunit structurei

Interacts with RRT2. Interacts with TRM7; for 2'-O-methylation of position 34 in substrate tRNAs.2 Publications

Protein-protein interaction databases

BioGridi36000. 173 interactors.
IntActiQ08924. 1 interactor.
MINTiMINT-2492169.
STRINGi4932.YPL183C.

Structurei

3D structure databases

ProteinModelPortaliQ08924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 41WD 1Add BLAST37
Repeati45 – 84WD 2Add BLAST40
Repeati132 – 174WD 3Add BLAST43
Repeati177 – 216WD 4Add BLAST40
Repeati219 – 258WD 5Add BLAST40
Repeati269 – 308WD 6Add BLAST40
Repeati465 – 504WD 7Add BLAST40
Repeati586 – 625WD 8Add BLAST40
Repeati652 – 702WD 9Add BLAST51
Repeati709 – 747WD 10Add BLAST39
Repeati761 – 804WD 11Add BLAST44
Repeati811 – 852WD 12Add BLAST42
Repeati880 – 928WD 13Add BLAST49
Repeati934 – 973WD 14Add BLAST40
Repeati975 – 1013WD 15Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat WDR6 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00420000029923.
InParanoidiQ08924.
OMAiMHLSSHR.
OrthoDBiEOG092C17MN.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 9 hits.
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLSHYGPA LCVKFYNDYV LAGYGPFIHV YDYHSATLIN KCRLFHYNKV
60 70 80 90 100
HGLSLSSEGK ILAYGARSVT IVELEDVLKK ESLVDFERIN SDWITGATFS
110 120 130 140 150
FDNLQIYLLT CYNKVLICDL NCEVLFRKSL GGERSILYSG IIKVFGPDKV
160 170 180 190 200
YVNAGTVMGG VIIWDLFSET KIHNLLGHEG SIFYVNLSNN GRYVASCSDD
210 220 230 240 250
RSIRLWDLET GKQLSVGWSH TARIWNLMFF DNDSKLISVS EDCTCRVWNI
260 270 280 290 300
IESRENVAEL SISNVYEVHL IKSIWGVDVK DDEMIAVTSG NDGRLKLIDL
310 320 330 340 350
LQLKRHGDEE TSFSLDDIAK QCGDIFEKNE SIKGFQWFSF GVIAITSLGK
360 370 380 390 400
ILKYSDVTKQ WKLLLTNEKF NSYPITNGIQ TQNIAVFSNN KSDILLIKFS
410 420 430 440 450
KDSADIIETE EFHLDELSKT NNCLVTEYDD DSFLLTLQSP NPREKFVCLE
460 470 480 490 500
ISLQNLKIKS KHCFNKPENF SSSCLTSFRN HILVGSRFST LVIYNLLDES
510 520 530 540 550
EEPFIIRRLS PGDTTTSIEF VEDKDNSAVF SVTNRDGYYV FIELTKNSLE
560 570 580 590 600
EGPYRLSYKV LHSNKMMKGF LEGAFFNSKG EYITYGFKSS LFYLYNETNC
610 620 630 640 650
YELASEVCGG SHRLWNLAKI TDGHVLMYIK ASRFHLRKIY NSIVPETLEN
660 670 680 690 700
GVHGREIRDI SICPVSNTNT NDNFKDGHIF CTASEDTTIK LGYFNNRTGK
710 720 730 740 750
VQNFWTQRKH VSGLQRCQFI NHKLMISSSA REELFLWELN DKYNKRPYMT
760 770 780 790 800
IRQALPVSTN NSDLRIMDFD VKFISQSGDF LLVTVYSDST IKIWHYRENQ
810 820 830 840 850
NKFDLIMQGR YKTCCLFNVV FIALKEELLV VISPTDGHLV VYNITEYVPF
860 870 880 890 900
SVDPISGDLV DHKLDATISN LPAPVAQLPV HQSGVKSLDY VANATRTSAT
910 920 930 940 950
ILTGGDDNGL GLSNLKLDDS NKVTLKTSDF IAAAASSTIT SGMLINGGKE
960 970 980 990 1000
VITTSVDQVI RAWEITAGKL SLVDKKRTTV ADTGSLEIIS NDEDADSEKT
1010
LLIGGVGLSI WKK
Length:1,013
Mass (Da):114,461
Last modified:November 1, 1996 - v1
Checksum:i06E192AE4A0EE35F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73539 Genomic DNA. Translation: CAA97892.1.
BK006949 Genomic DNA. Translation: DAA11252.1.
PIRiS65195.
RefSeqiNP_015142.1. NM_001183997.1.

Genome annotation databases

EnsemblFungiiYPL183C; YPL183C; YPL183C.
GeneIDi855919.
KEGGisce:YPL183C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiWDR6_YEAST
AccessioniPrimary (citable) accession number: Q08924
Secondary accession number(s): D6W3I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names