Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Target of rapamycin complex 1 subunit TCO89

Gene

TCO89

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions.1 Publication

Miscellaneous

Present with 243 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • glycerol metabolic process Source: SGD
  • regulation of cell growth Source: SGD
  • response to salt stress Source: SGD
  • TOR signaling Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-34075-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Target of rapamycin complex 1 subunit TCO89
Short name:
TORC1 subunit TCO89
Alternative name(s):
89 kDa TOR complex 1 protein
Gene namesi
Name:TCO89
Ordered Locus Names:YPL180W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL180W.
SGDiS000006101. TCO89.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717861 – 799Target of rapamycin complex 1 subunit TCO89Add BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphothreonineCombined sources1
Modified residuei82PhosphothreonineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08921.
PRIDEiQ08921.

PTM databases

iPTMnetiQ08921.

Interactioni

Subunit structurei

The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36002. 191 interactors.
DIPiDIP-5347N.
IntActiQ08921. 21 interactors.
MINTiMINT-8285479.
STRINGi4932.YPL180W.

Structurei

3D structure databases

ProteinModelPortaliQ08921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TORC subunit TCO89 family.Curated

Phylogenomic databases

InParanoidiQ08921.
OMAiMILSQST.
OrthoDBiEOG092C3NMU.

Family and domain databases

InterProiView protein in InterPro
IPR018857. TORC1_cplx_su_TCO89.
PfamiView protein in Pfam
PF10452. TCO89. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHRGRTLKS DTDVTSLNAS TVSHQSKPFR QFSTRSRAKS NASFKGLRRV
60 70 80 90 100
LTHDGTLDND YFNKHNVSQK CKSSDALFRK RTISGLNMTA LTRVKSNQGK
110 120 130 140 150
RSASFHSPVH NTLLSPKNSS HSNTGTAGFG LKPRRSKSTQ SVLSLRDAQE
160 170 180 190 200
SKKSESTTDE EVECFSEDNI EDGKVNNDKV IAEHVMPEEK KNVQQLNQNE
210 220 230 240 250
LQSPDSIDEQ EEDKSGTDGK ENHRAVSLPL PHLSSNNYFG ESSHSIEHQK
260 270 280 290 300
DGETSPSSIE TKLNATSVIN EEGQSKVTKE ADIDDLSSHS QNLRASLVKA
310 320 330 340 350
GDNISEAPYD KEKKILDVGN TLAAHKSNQK PSHSDEQFDQ EDHIDAPRSN
360 370 380 390 400
SSRKSDSSFM SLRRQSSKQH KLLNEEEDLI KPDDISSAGT KDIEGHSLLE
410 420 430 440 450
NYAPNMILSQ STGVERRFEN SSSIQNSLGN EIHDSGEHMA SGDTFNELDD
460 470 480 490 500
GKLRKSKKNG GRSQLGQNIP NSQSTFPTIA NIGSKDNNVP QHNFSTSISS
510 520 530 540 550
LTNNLRRAAP ESFHGSRMNN IFHKKGNQNL LLRSNDLNKN SAAPASPLSN
560 570 580 590 600
EHITSSTNSG SDANRQSNSG AKFNSFAQFL KSDGIDAESR TQRKLWLQRE
610 620 630 640 650
NSIMDLSSQN DGSDSIFMAG NIDAKREFER ISHEYSNVKR FYNPLDEALL
660 670 680 690 700
RVQPIITGNA NNIRKKSHND AQSIAHSSSD TDHKDEDDLL FTNYDKKFDD
710 720 730 740 750
LYPHLASAKI QAVLSGIWKS ESYLFNKDVN PINKNRTTST NHSVGHTASQ
760 770 780 790
NARNLLRGPM GSSTTLHHQR VINSLQPTTR AVNRRMENVG YMHTQPQQR
Length:799
Mass (Da):88,845
Last modified:November 1, 1996 - v1
Checksum:i7243C08F4C74633D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73536 Genomic DNA. Translation: CAA97887.1.
BK006949 Genomic DNA. Translation: DAA11254.1.
PIRiS65192.
RefSeqiNP_015145.1. NM_001183994.1.

Genome annotation databases

EnsemblFungiiYPL180W; YPL180W; YPL180W.
GeneIDi855922.
KEGGisce:YPL180W.

Similar proteinsi

Entry informationi

Entry nameiTCO89_YEAST
AccessioniPrimary (citable) accession number: Q08921
Secondary accession number(s): D6W3I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names