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Q08911

- FDH1_YEAST

UniProt

Q08911 - FDH1_YEAST

Protein

Formate dehydrogenase 1

Gene

FDH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei272 – 2721By similarity
    Binding sitei296 – 2961NADBy similarity
    Active sitei325 – 3251Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi176 – 1772NADBy similarity
    Nucleotide bindingi270 – 2723NADBy similarity
    Nucleotide bindingi325 – 3284NADBy similarity

    GO - Molecular functioni

    1. formate dehydrogenase (NAD+) activity Source: SGD
    2. NAD binding Source: InterPro
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. formate catabolic process Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciYEAST:YOR388C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase 1 (EC:1.2.1.2)
    Alternative name(s):
    NAD-dependent formate dehydrogenase 1
    Gene namesi
    Name:FDH1
    Ordered Locus Names:YOR388C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR388c.
    SGDiS000005915. FDH1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Formate dehydrogenase 1PRO_0000223647Add
    BLAST

    Proteomic databases

    PaxDbiQ08911.

    Expressioni

    Inductioni

    Induced by formate.1 Publication

    Gene expression databases

    GenevestigatoriQ08911.

    Interactioni

    Protein-protein interaction databases

    BioGridi34769. 35 interactions.
    DIPiDIP-5327N.
    IntActiQ08911. 4 interactions.
    MINTiMINT-530466.
    STRINGi4932.YOR388C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08911.
    SMRiQ08911. Positions 4-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1052.
    HOGENOMiHOG000136703.
    KOiK00122.
    OMAiTEHMIND.
    OrthoDBiEOG769ZV3.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08911-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKGKVLLVL YEGGKHAEEQ EKLLGCIENE LGIRNFIEEQ GYELVTTIDK    50
    DPEPTSTVDR ELKDAEIVIT TPFFPAYISR NRIAEAPNLK LCVTAGVGSD 100
    HVDLEAANER KITVTEVTGS NVVSVAEHVM ATILVLIRNY NGGHQQAING 150
    EWDIAGVAKN EYDLEDKIIS TVGAGRIGYR VLERLVAFNP KKLLYYDYQE 200
    LPAEAINRLN EASKLFNGRG DIVQRVEKLE DMVAQSDVVT INCPLHKDSR 250
    GLFNKKLISH MKDGAYLVNT ARGAICVAED VAEAVKSGKL AGYGGDVWDK 300
    QPAPKDHPWR TMDNKDHVGN AMTVHISGTS LDAQKRYAQG VKNILNSYFS 350
    KKFDYRPQDI IVQNGSYATR AYGQKK 376
    Length:376
    Mass (Da):41,714
    Last modified:November 1, 1996 - v1
    Checksum:i67ECDA6F9DDC2A02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75296 Genomic DNA. Translation: CAA99720.1.
    BK006948 Genomic DNA. Translation: DAA11147.1.
    PIRiS67300.
    RefSeqiNP_015033.1. NM_001183808.1.

    Genome annotation databases

    EnsemblFungiiYOR388C; YOR388C; YOR388C.
    GeneIDi854570.
    KEGGisce:YOR388C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75296 Genomic DNA. Translation: CAA99720.1 .
    BK006948 Genomic DNA. Translation: DAA11147.1 .
    PIRi S67300.
    RefSeqi NP_015033.1. NM_001183808.1.

    3D structure databases

    ProteinModelPortali Q08911.
    SMRi Q08911. Positions 4-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34769. 35 interactions.
    DIPi DIP-5327N.
    IntActi Q08911. 4 interactions.
    MINTi MINT-530466.
    STRINGi 4932.YOR388C.

    Proteomic databases

    PaxDbi Q08911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR388C ; YOR388C ; YOR388C .
    GeneIDi 854570.
    KEGGi sce:YOR388C.

    Organism-specific databases

    CYGDi YOR388c.
    SGDi S000005915. FDH1.

    Phylogenomic databases

    eggNOGi COG1052.
    HOGENOMi HOG000136703.
    KOi K00122.
    OMAi TEHMIND.
    OrthoDBi EOG769ZV3.

    Enzyme and pathway databases

    BioCyci YEAST:YOR388C-MONOMER.

    Miscellaneous databases

    NextBioi 977021.

    Gene expression databases

    Genevestigatori Q08911.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Expression cassettes for formaldehyde and fluoroacetate resistance, two dominant markers in Saccharomyces cerevisiae."
      van den Berg M.A., Steensma H.Y.
      Yeast 13:551-559(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae."
      Overkamp K.M., Koetter P., van der Hoek R., Schoondermark-Stolk S., Luttik M.A.H., van Dijken J.P., Pronk J.T.
      Yeast 19:509-520(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.

    Entry informationi

    Entry nameiFDH1_YEAST
    AccessioniPrimary (citable) accession number: Q08911
    Secondary accession number(s): D6W381
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3