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Protein

Formate dehydrogenase 1

Gene

FDH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721By similarity
Binding sitei296 – 2961NADBy similarity
Active sitei325 – 3251Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 1772NADBy similarity
Nucleotide bindingi270 – 2723NADBy similarity
Nucleotide bindingi325 – 3284NADBy similarity

GO - Molecular functioni

  1. formate dehydrogenase (NAD+) activity Source: SGD
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. formate catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciYEAST:YOR388C-MONOMER.
BRENDAi1.2.1.2. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase 1 (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase 1
Gene namesi
Name:FDH1
Ordered Locus Names:YOR388C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

CYGDiYOR388c.
SGDiS000005915. FDH1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Formate dehydrogenase 1PRO_0000223647Add
BLAST

Proteomic databases

PaxDbiQ08911.

Expressioni

Inductioni

Induced by formate.1 Publication

Gene expression databases

ExpressionAtlasiQ08911. differential.
GenevestigatoriQ08911.

Interactioni

Protein-protein interaction databases

BioGridi34769. 35 interactions.
DIPiDIP-5327N.
IntActiQ08911. 4 interactions.
MINTiMINT-530466.
STRINGi4932.YOR388C.

Structurei

3D structure databases

ProteinModelPortaliQ08911.
SMRiQ08911. Positions 4-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
InParanoidiQ08911.
KOiK00122.
OMAiENYFAGK.
OrthoDBiEOG769ZV3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGKVLLVL YEGGKHAEEQ EKLLGCIENE LGIRNFIEEQ GYELVTTIDK
60 70 80 90 100
DPEPTSTVDR ELKDAEIVIT TPFFPAYISR NRIAEAPNLK LCVTAGVGSD
110 120 130 140 150
HVDLEAANER KITVTEVTGS NVVSVAEHVM ATILVLIRNY NGGHQQAING
160 170 180 190 200
EWDIAGVAKN EYDLEDKIIS TVGAGRIGYR VLERLVAFNP KKLLYYDYQE
210 220 230 240 250
LPAEAINRLN EASKLFNGRG DIVQRVEKLE DMVAQSDVVT INCPLHKDSR
260 270 280 290 300
GLFNKKLISH MKDGAYLVNT ARGAICVAED VAEAVKSGKL AGYGGDVWDK
310 320 330 340 350
QPAPKDHPWR TMDNKDHVGN AMTVHISGTS LDAQKRYAQG VKNILNSYFS
360 370
KKFDYRPQDI IVQNGSYATR AYGQKK
Length:376
Mass (Da):41,714
Last modified:October 31, 1996 - v1
Checksum:i67ECDA6F9DDC2A02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75296 Genomic DNA. Translation: CAA99720.1.
BK006948 Genomic DNA. Translation: DAA11147.1.
PIRiS67300.
RefSeqiNP_015033.1. NM_001183808.1.

Genome annotation databases

EnsemblFungiiYOR388C; YOR388C; YOR388C.
GeneIDi854570.
KEGGisce:YOR388C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75296 Genomic DNA. Translation: CAA99720.1.
BK006948 Genomic DNA. Translation: DAA11147.1.
PIRiS67300.
RefSeqiNP_015033.1. NM_001183808.1.

3D structure databases

ProteinModelPortaliQ08911.
SMRiQ08911. Positions 4-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34769. 35 interactions.
DIPiDIP-5327N.
IntActiQ08911. 4 interactions.
MINTiMINT-530466.
STRINGi4932.YOR388C.

Proteomic databases

PaxDbiQ08911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR388C; YOR388C; YOR388C.
GeneIDi854570.
KEGGisce:YOR388C.

Organism-specific databases

CYGDiYOR388c.
SGDiS000005915. FDH1.

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
InParanoidiQ08911.
KOiK00122.
OMAiENYFAGK.
OrthoDBiEOG769ZV3.

Enzyme and pathway databases

BioCyciYEAST:YOR388C-MONOMER.
BRENDAi1.2.1.2. 984.

Miscellaneous databases

NextBioi977021.

Gene expression databases

ExpressionAtlasiQ08911. differential.
GenevestigatoriQ08911.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Expression cassettes for formaldehyde and fluoroacetate resistance, two dominant markers in Saccharomyces cerevisiae."
    van den Berg M.A., Steensma H.Y.
    Yeast 13:551-559(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae."
    Overkamp K.M., Koetter P., van der Hoek R., Schoondermark-Stolk S., Luttik M.A.H., van Dijken J.P., Pronk J.T.
    Yeast 19:509-520(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiFDH1_YEAST
AccessioniPrimary (citable) accession number: Q08911
Secondary accession number(s): D6W381
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2006
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.