Reviewed,
UniProtKB/Swiss-Prot Q08911 (FDH1_YEAST)
Last modified
January 19, 2010.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Formate dehydrogenase 1 EC=1.2.1.2 Alternative name(s): NAD-dependent formate dehydrogenase 1 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Formate + NAD+ = CO2 + NADH. |
| Subcellular location | |
| Induction | Induced by formate. Ref.3 |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | NADH regeneration Ref.3 Traceable author statement. Source: SGD formate catabolic process Ref.3Inferred from genetic interaction. Source: SGD oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Ref.3 Inferred from direct assay. Source: SGD |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: InterPro formate dehydrogenase activity Ref.3Inferred from genetic interaction. Source: SGD oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 376 | 376 | Formate dehydrogenase 1 | PRO_0000223647 | |||||
Regions | |||||||||
| Nucleotide binding | 176 – 177 | 2 | NAD By similarity | ||||||
| Nucleotide binding | 270 – 272 | 3 | NAD By similarity | ||||||
| Nucleotide binding | 325 – 328 | 4 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 272 | 1 | By similarity | ||||||
| Active site | 325 | 1 | Proton donor By similarity | ||||||
| Binding site | 296 | 1 | NAD By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z75296 Genomic DNA. Translation: CAA99720.1. |
| PIR | S67300. |
| RefSeq | NP_015033.1. |
3D structure databases | |
| SMR | Q08911. Positions 4-367. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-5327N. |
| IntAct | Q08911. 5 interactions. |
| STRING | Q08911. |
Genome annotation databases | |
| Ensembl | YOR388C; YOR388C; YOR388C; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 854570. |
| KEGG | sce:YOR388C. |
| NMPDR | fig|4932.3.peg.6154. |
Organism-specific databases | |
| CYGD | YOR388c. |
| SGD | S000005915. FDH1. |
Phylogenomic databases | |
| eggNOG | fuNOG06903. |
| HOGENOM | HBG328050. |
| OMA | KLEDMVA. |
| OrthoDB | EOG9JDJQ8. |
| PhylomeDB | Q08911. |
Enzyme and pathway databases | |
| BRENDA | 1.2.1.2. 250. |
Gene expression databases | |
| Genevestigator | Q08911. |
| GermOnline | YOR388C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. False negative. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 977021. |
Entry information
| Entry name | FDH1_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q08911 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |

Clusters with


