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Protein

Protein RDR1

Gene

RDR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor of multidrug resistance genes, such as PDR5. Required for growth on non-fermentable carbon sources like lactate or glycerol.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 4627Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • response to xenobiotic stimulus Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33843-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RDR1
Alternative name(s):
Repressor of drug resistance protein 1
Gene namesi
Name:RDR1
Ordered Locus Names:YOR380W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR380W.
SGDiS000005907. RDR1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Protein RDR1PRO_0000114972Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi34761. 22 interactions.
DIPiDIP-3904N.
IntActiQ08904. 9 interactions.
MINTiMINT-508330.

Structurei

3D structure databases

ProteinModelPortaliQ08904.
SMRiQ08904. Positions 18-49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000159128.
InParanoidiQ08904.
OMAiAFPHILG.
OrthoDBiEOG092C18OZ.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGSTALP HKRQRVRKAC VPCRERKRKC NGKSPCEMCV AYGYVCHYID
60 70 80 90 100
GRVPSASPQV QQVGETSPDT ESRPFVLPGI HRNEQPQPIN TQNVTSQNIV
110 120 130 140 150
DPTKSRYTIQ HSAVAFPRCL GLELRSTNPP RLHSFAWHCG IRPEENPNSH
160 170 180 190 200
VLLSDLVTKE EYYRISKVYF SVVHPIFDVV NPEQLAKNVE KYWDGDVKTL
210 220 230 240 250
EYGAVIAGVI ALGSFFMGSL GHPREMDIVQ YAKGILDDPT FSRIPTVEQV
260 270 280 290 300
SAWVLRTIYL RATSRPHVAW LASCVTIHLS EAIGLHHEID REDIAISNNV
310 320 330 340 350
PPKRTTVVSE HTRRLFWCAW SINTILSYDY GRSSVTLNRI TCKPVKETDG
360 370 380 390 400
NFTAHLVALA HLIPQDSVNA NAAQLLQALA AVHESPNAHP FLSLTKGDIC
410 420 430 440 450
LSLYRRLRLL NHILDKNVVL QIIDIGNTAL SAAYALVKLD QAWWNVLSTS
460 470 480 490 500
FQYVCVLLAI DTPESLSHVA TAMKTLDNIT QILGTRIAFE AQKTAKLLLE
510 520 530 540
DSMKKKRQEI QQLEQATHQR SNLETTHLLD IDWDALLDPS DTLNFM
Length:546
Mass (Da):61,287
Last modified:November 1, 1996 - v1
Checksum:i208D4572E24244F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75288 Genomic DNA. Translation: CAA99712.1.
BK006948 Genomic DNA. Translation: DAA11138.1.
PIRiS67292.
RefSeqiNP_015025.3. NM_001183800.3.

Genome annotation databases

EnsemblFungiiYOR380W; YOR380W; YOR380W.
GeneIDi854562.
KEGGisce:YOR380W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75288 Genomic DNA. Translation: CAA99712.1.
BK006948 Genomic DNA. Translation: DAA11138.1.
PIRiS67292.
RefSeqiNP_015025.3. NM_001183800.3.

3D structure databases

ProteinModelPortaliQ08904.
SMRiQ08904. Positions 18-49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34761. 22 interactions.
DIPiDIP-3904N.
IntActiQ08904. 9 interactions.
MINTiMINT-508330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR380W; YOR380W; YOR380W.
GeneIDi854562.
KEGGisce:YOR380W.

Organism-specific databases

EuPathDBiFungiDB:YOR380W.
SGDiS000005907. RDR1.

Phylogenomic databases

HOGENOMiHOG000159128.
InParanoidiQ08904.
OMAiAFPHILG.
OrthoDBiEOG092C18OZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-33843-MONOMER.

Miscellaneous databases

PROiQ08904.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDR1_YEAST
AccessioniPrimary (citable) accession number: Q08904
Secondary accession number(s): D6W372
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.