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Protein

Drug resistance protein YOR378W

Gene

YOR378W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-dependent export permease involved in drug resistance through pumping them out of the cell.By similarity

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: SGD

GO - Biological processi

  • ammonium transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33842-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.52. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Drug resistance protein YOR378W
Gene namesi
Ordered Locus Names:YOR378W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR378W.
SGDiS000005905. YOR378W.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878ExtracellularSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Topological domaini100 – 11112CytoplasmicSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Topological domaini133 – 1408ExtracellularSequence analysis
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 17110CytoplasmicSequence analysis
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Topological domaini193 – 20210ExtracellularSequence analysis
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 24118CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST
Topological domaini263 – 2708ExtracellularSequence analysis
Transmembranei271 – 29121HelicalSequence analysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Topological domaini332 – 34615ExtracellularSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Topological domaini368 – 3747CytoplasmicSequence analysis
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Topological domaini396 – 4038ExtracellularSequence analysis
Transmembranei404 – 42421HelicalSequence analysisAdd
BLAST
Topological domaini425 – 43511CytoplasmicSequence analysisAdd
BLAST
Transmembranei436 – 45621HelicalSequence analysisAdd
BLAST
Topological domaini457 – 47923ExtracellularSequence analysisAdd
BLAST
Transmembranei480 – 50021HelicalSequence analysisAdd
BLAST
Topological domaini501 – 51515CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Drug resistance protein YOR378WPRO_0000244476Add
BLAST

Expressioni

Inductioni

By neocarzinostatin and during G2 phase of cell cycle.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi34760. 10 interactions.
DIPiDIP-4051N.
MINTiMINT-557411.

Structurei

3D structure databases

ProteinModelPortaliQ08902.
SMRiQ08902. Positions 181-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000001190.
HOGENOMiHOG000174951.
InParanoidiQ08902.
OMAiWRIEARI.
OrthoDBiEOG092C0YLE.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSSSVTQK NLDTNAEALK KEDKVLSEFD IQDERPKSLL WESAFVGVLC
60 70 80 90 100
SAQLMTQAGL GQSLAPLHII GNSFGTTNAG QLSWFASAYS LTVGTFILIA
110 120 130 140 150
GRLGDIFGHK KFFVLGFFWY ALWSLLAGFS VYSNQIFFDC CRAFQGMGPA
160 170 180 190 200
FLLPNAIAIL GRTYKPGRRK NMVFSLFGAS APGGFFLGAV FSSMLGQLAW
210 220 230 240 250
WPWAYWIMGI ACFVLAVAGY FVIPHTPMPS RDASSFKLLE RIDFAGSVTG
260 270 280 290 300
VVGLILFNFA WNQGPVVGWQ TPYTYALLIV GTFFLVIFAY IESRAAFPLL
310 320 330 340 350
PFAALSSDTA FVLSCIAAGW ASFGIWIFYT WQFMEDSRGQ TPLLSSAQFS
360 370 380 390 400
PVAISGFCAA VTTGFLLSHT PPSTVMLFAM TAFTVGTILI ATAPVHQTYW
410 420 430 440 450
AQTFVSIIVM PWGMDMSFPA ATIMLSDSMP HEHQGLAASL VNTVVNYSIS
460 470 480 490 500
IGLGIAGTIE SRVNDGGAKP LKGYRCSWYM GIGLSGLGIF VAATYAWSTF
510
MKSKKRISEK QHFIE
Length:515
Mass (Da):56,110
Last modified:November 1, 1996 - v1
Checksum:i2A74E99CDCC433C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75286 Genomic DNA. Translation: CAA99709.1.
BK006948 Genomic DNA. Translation: DAA11137.1.
PIRiS67290.
RefSeqiNP_015023.1. NM_001183798.1.

Genome annotation databases

EnsemblFungiiYOR378W; YOR378W; YOR378W.
GeneIDi854560.
KEGGisce:YOR378W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75286 Genomic DNA. Translation: CAA99709.1.
BK006948 Genomic DNA. Translation: DAA11137.1.
PIRiS67290.
RefSeqiNP_015023.1. NM_001183798.1.

3D structure databases

ProteinModelPortaliQ08902.
SMRiQ08902. Positions 181-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34760. 10 interactions.
DIPiDIP-4051N.
MINTiMINT-557411.

Protein family/group databases

TCDBi2.A.1.3.52. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR378W; YOR378W; YOR378W.
GeneIDi854560.
KEGGisce:YOR378W.

Organism-specific databases

EuPathDBiFungiDB:YOR378W.
SGDiS000005905. YOR378W.

Phylogenomic databases

GeneTreeiENSGT00390000001190.
HOGENOMiHOG000174951.
InParanoidiQ08902.
OMAiWRIEARI.
OrthoDBiEOG092C0YLE.

Enzyme and pathway databases

BioCyciYEAST:G3O-33842-MONOMER.

Miscellaneous databases

PROiQ08902.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYO378_YEAST
AccessioniPrimary (citable) accession number: Q08902
Secondary accession number(s): D6W371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.