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Protein

Drug resistance protein YOR378W

Gene

YOR378W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-dependent export permease involved in drug resistance through pumping them out of the cell.By similarity

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: SGD

GO - Biological processi

  • ammonium transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33842-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.52. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Drug resistance protein YOR378W
Gene namesi
Ordered Locus Names:YOR378W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR378W.
SGDiS000005905. YOR378W.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78ExtracellularSequence analysisAdd BLAST78
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 111CytoplasmicSequence analysisAdd BLAST12
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 140ExtracellularSequence analysis8
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 171CytoplasmicSequence analysis10
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 202ExtracellularSequence analysis10
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 241CytoplasmicSequence analysisAdd BLAST18
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 270ExtracellularSequence analysis8
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 346ExtracellularSequence analysisAdd BLAST15
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 374CytoplasmicSequence analysis7
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 403ExtracellularSequence analysis8
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 435CytoplasmicSequence analysisAdd BLAST11
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21
Topological domaini457 – 479ExtracellularSequence analysisAdd BLAST23
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 515CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444761 – 515Drug resistance protein YOR378WAdd BLAST515

Proteomic databases

PRIDEiQ08902.

Expressioni

Inductioni

By neocarzinostatin and during G2 phase of cell cycle.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi34760. 10 interactors.
DIPiDIP-4051N.
MINTiMINT-557411.

Structurei

3D structure databases

ProteinModelPortaliQ08902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000001190.
HOGENOMiHOG000174951.
InParanoidiQ08902.
OMAiWRIEARI.
OrthoDBiEOG092C0YLE.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSSSVTQK NLDTNAEALK KEDKVLSEFD IQDERPKSLL WESAFVGVLC
60 70 80 90 100
SAQLMTQAGL GQSLAPLHII GNSFGTTNAG QLSWFASAYS LTVGTFILIA
110 120 130 140 150
GRLGDIFGHK KFFVLGFFWY ALWSLLAGFS VYSNQIFFDC CRAFQGMGPA
160 170 180 190 200
FLLPNAIAIL GRTYKPGRRK NMVFSLFGAS APGGFFLGAV FSSMLGQLAW
210 220 230 240 250
WPWAYWIMGI ACFVLAVAGY FVIPHTPMPS RDASSFKLLE RIDFAGSVTG
260 270 280 290 300
VVGLILFNFA WNQGPVVGWQ TPYTYALLIV GTFFLVIFAY IESRAAFPLL
310 320 330 340 350
PFAALSSDTA FVLSCIAAGW ASFGIWIFYT WQFMEDSRGQ TPLLSSAQFS
360 370 380 390 400
PVAISGFCAA VTTGFLLSHT PPSTVMLFAM TAFTVGTILI ATAPVHQTYW
410 420 430 440 450
AQTFVSIIVM PWGMDMSFPA ATIMLSDSMP HEHQGLAASL VNTVVNYSIS
460 470 480 490 500
IGLGIAGTIE SRVNDGGAKP LKGYRCSWYM GIGLSGLGIF VAATYAWSTF
510
MKSKKRISEK QHFIE
Length:515
Mass (Da):56,110
Last modified:November 1, 1996 - v1
Checksum:i2A74E99CDCC433C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75286 Genomic DNA. Translation: CAA99709.1.
BK006948 Genomic DNA. Translation: DAA11137.1.
PIRiS67290.
RefSeqiNP_015023.1. NM_001183798.1.

Genome annotation databases

EnsemblFungiiYOR378W; YOR378W; YOR378W.
GeneIDi854560.
KEGGisce:YOR378W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75286 Genomic DNA. Translation: CAA99709.1.
BK006948 Genomic DNA. Translation: DAA11137.1.
PIRiS67290.
RefSeqiNP_015023.1. NM_001183798.1.

3D structure databases

ProteinModelPortaliQ08902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34760. 10 interactors.
DIPiDIP-4051N.
MINTiMINT-557411.

Protein family/group databases

TCDBi2.A.1.3.52. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiQ08902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR378W; YOR378W; YOR378W.
GeneIDi854560.
KEGGisce:YOR378W.

Organism-specific databases

EuPathDBiFungiDB:YOR378W.
SGDiS000005905. YOR378W.

Phylogenomic databases

GeneTreeiENSGT00390000001190.
HOGENOMiHOG000174951.
InParanoidiQ08902.
OMAiWRIEARI.
OrthoDBiEOG092C0YLE.

Enzyme and pathway databases

BioCyciYEAST:G3O-33842-MONOMER.

Miscellaneous databases

PROiQ08902.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYO378_YEAST
AccessioniPrimary (citable) accession number: Q08902
Secondary accession number(s): D6W371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.