ID   Q088L2_SHEFN            Unreviewed;       819 AA.
AC   Q088L2;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE   AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN   OrderedLocusNames=Sfri_0441 {ECO:0000313|EMBL:ABI70303.1};
OS   Shewanella frigidimarina (strain NCIMB 400).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318167 {ECO:0000313|EMBL:ABI70303.1, ECO:0000313|Proteomes:UP000000684};
RN   [1] {ECO:0000313|EMBL:ABI70303.1, ECO:0000313|Proteomes:UP000000684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCIMB 400 {ECO:0000313|EMBL:ABI70303.1,
RC   ECO:0000313|Proteomes:UP000000684};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H.,
RA   Newman D., Tiedje J.M., Zhou J., Romine M.F., Culley D.E., Serres M.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.;
RT   "Complete sequence of Shewanella frigidimarina NCIMB 400.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; CP000447; ABI70303.1; -; Genomic_DNA.
DR   RefSeq; WP_011635930.1; NC_008345.1.
DR   AlphaFoldDB; Q088L2; -.
DR   STRING; 318167.Sfri_0441; -.
DR   KEGG; sfr:Sfri_0441; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000000684; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000684}.
FT   DOMAIN          10..203
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   819 AA;  94125 MW;  C963A2AD85189F9A CRC64;
     MTDKTAYYQK DLAEKLNGIR LARVLNVLPE SQLHLFHLIP FLIHHNQINV PGIIDPDTPC
     GIHGFTLSDA IVSACDALSL SIPEMIQPSD CVFEGIYAMG STASFGQNPQ SDVDIWLVYN
     SKLTDDQLKL IEYKNKLISD WFAGFEFEVN FYLVHPMQFR ECSAFDNCQP VGLEHSGSSQ
     HWLLLEEFYR SHIRLAGKVV AWWPDANSQN TEFDASLLYL GDINSLPAAE YFGASLWQLY
     KGLNKPHKAL LKVLLLETYA SEYPSTTLIT QQIWQYCEQQ DFSVDNDAYL LLYQRIETYL
     IAQGDDNRLE IVRRCFYLKS GVTLSCLSPN SAADWRVEKI QNLVKQWAWS HELVATLDNS
     PYWHAGQLKW FNQQLSELLL VSYKNLLQFA SKQTLSERMR VEELGLLARK LHTYFSEDTH
     LLQPLNRLWS LSTAEKSLTI FHCRQASRFY LYRQAYLDKD PSQAVDNDPA HEFDDHSIHE
     ADNICNLVAW SVLNGLATAD TQWFQVGRGK RRTDKLSYLT RKLIPIMHNV PTVYKRDLCE
     PWCYQKIVLI TNMDRDPTTQ LSEQELILEH VNANILSFGQ TKISMVSSVA IVCLNSWGEW
     QSHRFNGKTA LLEAISFIIL GLKRSNEQVD LSIISCSAKL KQPIFNQLKT LLLRCYGLMK
     KVNQTNTLMH PITIGEQHYS MHFNSLGMMY RKVDLITGTG NFNSSVLPYA DLAEDPYLNS
     PSVIQKFIVM GAKQYFLRER HQTLDVFIAD DNNQLEHLQY QHTSINDFVA KESHLYVFDE
     QKQRSPVFNM PQFFQLVDIE GKLTVIPFGL SVDEMGSAF
//