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Q088G0

- PUR9_SHEFN

UniProt

Q088G0 - PUR9_SHEFN

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-515-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Sfri_0493
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000018952Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318167.Sfri_0493.

Structurei

3D structure databases

ProteinModelPortaliQ088G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q088G0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNVRPIRRA LLSVSDKTGI LEFAQALHAQ GVELLSTGGT AKLLADNNIP
60 70 80 90 100
VMEVSDYTGH PEIMDGRVKT LHPKIHGGIL ARRGIDEIVM EQNAIKPIDL
110 120 130 140 150
VTVNLYPFAE TVAKPGCTLA DAVENIDIGG PTMVRSTAKN HKDTTIVVNA
160 170 180 190 200
KDYGRVIAEM QANNGSTTLE TRFDLAIAAF EHTAAYDGMI ANYFGTMVPA
210 220 230 240 250
HSNDECHDDS TFPRTFNSQF VKKQDLRYGE NSHQKAAFYV DTQIDEASVA
260 270 280 290 300
SAIQLQGKAL SYNNIADTDS ALECVKEFEG PACVIVKHAN PCGVALGANL
310 320 330 340 350
LEAYDRAFKT DPTSAFGGII AFNQELDAQT AQAIVDRQFV EVIIAPKVSQ
360 370 380 390 400
AARDIIAAKA NVRLLECGEW NTKTTTLDYK RVNGGLLIQD RDQGMVNLED
410 420 430 440 450
VKVVSKRQPT AEQLKDLMFC WKVAKFVKSN AIVYAKDGMT IGVGAGQMSR
460 470 480 490 500
VYSAKIAGIK AADEGLVVEN SVMASDAFFP FRDGIDAAAA AGISCIIQPG
510 520
GSIRDEEIIA AADEHGMAMV FTGMRHFRH
Length:529
Mass (Da):57,247
Last modified:October 31, 2006 - v1
Checksum:i7A8C35EDB35BF4E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI70355.1.
RefSeqiWP_011635982.1. NC_008345.1.
YP_749193.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI70355; ABI70355; Sfri_0493.
GeneIDi4278574.
KEGGisfr:Sfri_0493.
PATRICi23494767. VBISheFri14343_0509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI70355.1 .
RefSeqi WP_011635982.1. NC_008345.1.
YP_749193.1. NC_008345.1.

3D structure databases

ProteinModelPortali Q088G0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318167.Sfri_0493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI70355 ; ABI70355 ; Sfri_0493 .
GeneIDi 4278574.
KEGGi sfr:Sfri_0493.
PATRICi 23494767. VBISheFri14343_0509.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SFRI318167:GIXS-515-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiPUR9_SHEFN
AccessioniPrimary (citable) accession number: Q088G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3