Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08890

- IDS_MOUSE

UniProt

Q08890 - IDS_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Iduronate 2-sulfatase

Gene

Ids

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.1 Publication

Catalytic activityi

Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471CalciumBy similarity
Metal bindingi48 – 481CalciumBy similarity
Metal bindingi86 – 861Calcium; via 3-oxoalanineBy similarity
Metal bindingi336 – 3361CalciumBy similarity
Metal bindingi337 – 3371CalciumBy similarity

GO - Molecular functioni

  1. iduronate-2-sulfatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. sulfuric ester hydrolase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198967. HS-GAG degradation.
REACT_198981. CS/DS degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Iduronate 2-sulfatase (EC:3.1.6.13)
Alternative name(s):
Alpha-L-iduronate sulfate sulfatase
Gene namesi
Name:Ids
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:96417. Ids.

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 356By similarityPRO_0000033431
Chaini36 – 552517Iduronate 2-sulfatasePRO_0000033432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 8613-oxoalanine (Cys)By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ08890.
PaxDbiQ08890.
PRIDEiQ08890.

PTM databases

PhosphoSiteiQ08890.

Expressioni

Tissue specificityi

Found to be expressed in alpha and beta pancreatic cells.1 Publication

Inductioni

By glucose, in a dose dependent manner.1 Publication

Gene expression databases

BgeeiQ08890.
CleanExiMM_IDS.
ExpressionAtlasiQ08890. baseline and differential.
GenevestigatoriQ08890.

Structurei

3D structure databases

ProteinModelPortaliQ08890.
SMRiQ08890. Positions 40-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3119.
GeneTreeiENSGT00730000110906.
HOVERGENiHBG006120.
InParanoidiQ08890.
KOiK01136.
OMAiDHNMYND.
OrthoDBiEOG7PK8ZR.
TreeFamiTF323156.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 2 hits.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08890-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPPPPPPIW RQLSFSLLLG SFCIALESAA QGNSATDALN ILLIIVDDLR
60 70 80 90 100
PSLGCYGDKL VRSPNIDQLA SHSVLFQNAF AQQAVCAPSR VSFLTGRRPD
110 120 130 140 150
TTRLYDFNSY WRVHSGNFST IPQYFKENGY VTMSVGKVFH PGISSNHSDD
160 170 180 190 200
YPYSWSFPPY HPSSEKYENT KTCKGQDGKL HANLLCPVDV ADVPEGTLPD
210 220 230 240 250
KQSTEEAIRL LEKMKTSASP FFLAVGYHKP HIPFRYPKEF QKLYPLENIT
260 270 280 290 300
LAPDPHVPDS LPPVAYNPWM DIREREDVQA LNISVPYGPI PEDFQRKIRQ
310 320 330 340 350
SYFASVSYLD TQVGHVLSAL DDLRLAHNTI IAFTSDHGWA LGEHGEWAKY
360 370 380 390 400
SNFDVATRVP LMLYVPGRTA PLPAAGQKLF PYRDPFDPAS DWMDAGRHTE
410 420 430 440 450
DLVELVSLFP TLAGLAGLPV PPRCPIPSFH VELCREGQNL QKHLQLHDLE
460 470 480 490 500
EEPDLFGNPR ELIAYSQYPR PADFPQWNSD KPSLNDIKVM GYSIRTVDYR
510 520 530 540 550
YTVWVGFDPS EFLANFSDIH AGELYFVDSD PLQDHNVYND SQHGGLLHSL

RP
Length:552
Mass (Da):62,186
Last modified:July 27, 2011 - v3
Checksum:i3E3D819A823AFDE5
GO

Sequence cautioni

The sequence AAA37880.1 differs from that shown. Reason: Frameshift at positions 420, 458, 488, 493 and 497.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411I → V in BAE38612. (PubMed:16141072)Curated
Sequence conflicti218 – 2181A → G in AAA37880. (PubMed:8325651)Curated
Sequence conflicti483 – 4831S → T in AAA37880. (PubMed:8325651)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK166178 mRNA. Translation: BAE38612.1.
BX294168 Genomic DNA. Translation: CAM20128.1.
L07921 mRNA. Translation: AAA37880.1. Frameshift.
BN000750 mRNA. Translation: CAI84996.1.
CCDSiCCDS40996.1.
PIRiA47153.
RefSeqiNP_034628.2. NM_010498.3.
UniGeneiMm.233083.

Genome annotation databases

EnsembliENSMUST00000101509; ENSMUSP00000099046; ENSMUSG00000035847.
GeneIDi15931.
KEGGimmu:15931.
UCSCiuc012hjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK166178 mRNA. Translation: BAE38612.1 .
BX294168 Genomic DNA. Translation: CAM20128.1 .
L07921 mRNA. Translation: AAA37880.1 . Frameshift.
BN000750 mRNA. Translation: CAI84996.1 .
CCDSi CCDS40996.1.
PIRi A47153.
RefSeqi NP_034628.2. NM_010498.3.
UniGenei Mm.233083.

3D structure databases

ProteinModelPortali Q08890.
SMRi Q08890. Positions 40-413.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q08890.

Proteomic databases

MaxQBi Q08890.
PaxDbi Q08890.
PRIDEi Q08890.

Protocols and materials databases

DNASUi 15931.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101509 ; ENSMUSP00000099046 ; ENSMUSG00000035847 .
GeneIDi 15931.
KEGGi mmu:15931.
UCSCi uc012hjl.1. mouse.

Organism-specific databases

CTDi 3423.
MGIi MGI:96417. Ids.

Phylogenomic databases

eggNOGi COG3119.
GeneTreei ENSGT00730000110906.
HOVERGENi HBG006120.
InParanoidi Q08890.
KOi K01136.
OMAi DHNMYND.
OrthoDBi EOG7PK8ZR.
TreeFami TF323156.

Enzyme and pathway databases

Reactomei REACT_198967. HS-GAG degradation.
REACT_198981. CS/DS degradation.

Miscellaneous databases

ChiTaRSi IDS. mouse.
NextBioi 288652.
PROi Q08890.
SOURCEi Search...

Gene expression databases

Bgeei Q08890.
CleanExi MM_IDS.
ExpressionAtlasi Q08890. baseline and differential.
Genevestigatori Q08890.

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view ]
Pfami PF00884. Sulfatase. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 2 hits.
PROSITEi PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Cloning and characterization of the cDNA for the murine iduronate sulfatase gene."
    Daniele A., Faust C.J., Herman G.E., di Natale P., Ballabio A.
    Genomics 16:755-757(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-552.
    Tissue: Thymus.
  4. "Identification of iduronate-2-sulfatase in mouse pancreatic islets."
    Coronado-Pons I., Novials A., Casas S., Clark A., Gomis R.
    Am. J. Physiol. 287:E983-E990(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  5. "Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."
    Sardiello M., Annunziata I., Roma G., Ballabio A.
    Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiIDS_MOUSE
AccessioniPrimary (citable) accession number: Q08890
Secondary accession number(s): Q32KI7, Q3TM30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3