Q08888 (SYR_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	BUsg_237

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 580	580	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000151540
Regions
	Motif	123 – 133	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q08888 [UniParc]. Last modified August 30, 2002. Version 2. Checksum: CFE972DC5DC43ED5	FASTA	580	68,043
	10 20 30 40 50 60 MNIKYLIKKD IEQALIKINS NYTYEVFIIS SKKIELGHYQ VDNLMKISSR LKIKPYKLFQ 70 80 90 100 110 120 KILILIEKKK IYKKIIFSHP GFINIFIKNE WLSEKLEIPF ISSRLGVKYI YPKKNIVIDY 130 140 150 160 170 180 SSPNIAKEMH VGHLRSTIIG DVTVRILEFL GQKVIRANHI GDWGTQFGIL IAYLEDKKLL 190 200 210 220 230 240 KKLKKNLLSL QDLDNIYCQS KKQYNSNELF SKKSREFVVK LQNGDQYCCA IWKKLVSITM 250 260 270 280 290 300 LENYKIYKKL NVTLEEKHTM GESFYNPMLP KIVEDLKKQK IAIEKNGAVI VFLDEFKNRM 310 320 330 340 350 360 GDSMGVIIRK KDKGFLYSTT DIACLKYRYQ NLHADRIIYY TDSRQYQHLL QSWTIAEKAN 370 380 390 400 410 420 YISKNLLLEH HMFGMMLSKN RRPFKTRDGN TIKLSNLLNE SINRATNLIQ KKQPNLCKKK 430 440 450 460 470 480 LIKLGEIIGI SAVKYSDLSK NRNTNYIFDW DKMLSFEGNT APYIQYAYTR IISILKKSNI 490 500 510 520 530 540 PLHKIKMKII LNEESEINLA IKILEFEEII LLIAKNGTPH IMCKYLYQLS TYFSHFYENC 550 560 570 580 SILFSEKIKI RKSRIKLSFL TAKTIKKGLN LLGIKTIKKM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.
[2]	"Buchnera aphidicola (a prokaryotic endosymbiont of aphids) contains a putative 16S rRNA operon unlinked to the 23S rRNA-encoding gene: sequence determination, and promoter and terminator analysis." Munson M.A., Baumann L., Baumann P. Gene 137:171-178(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-131.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67796.1. L18927 Genomic DNA. Translation: AAA17432.1.
PIR	I40591.
RefSeq	NP_660585.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q08888.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67796; AAM67796; BUsg_237.
GeneID	1005438.
KEGG	bas:BUsg237.
PATRIC	21247269. VBIBucAph100086_0248.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
KO	K01887.
OMA	QGAKCVF.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-298-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BUCAP

Accession

Primary (citable) accession number: Q08888

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	August 30, 2002
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program