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Q08887

- NDD1_YEAST

UniProt

Q08887 - NDD1_YEAST

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Protein

Nuclear division defective protein 1

Gene

NDD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription activator involved in G2/M transcription through its association with FKH2.7 Publications

GO - Molecular functioni

  1. transcription coactivator activity Source: SGD

GO - Biological processi

  1. positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear division defective protein 1
Gene namesi
Name:NDD1
Ordered Locus Names:YOR372C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR372c.
SGDiS000005899. NDD1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi319 – 3191T → A: Growth delay. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Nuclear division defective protein 1PRO_0000268686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191Phosphothreonine; by CDC282 Publications

Post-translational modificationi

Phosphorylation of Thr-319 by CDC28 is required for the interaction with FKH2 and recruitment to promoters.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08887.
PaxDbiQ08887.

Expressioni

Inductioni

During S phase of the cell cycle. Expression is cell cycle regulated by HCM1.2 Publications

Gene expression databases

GenevestigatoriQ08887.

Interactioni

Subunit structurei

Forms an activator complex with FKH2.

Protein-protein interaction databases

BioGridi34755. 19 interactions.
DIPiDIP-1806N.
IntActiQ08887. 4 interactions.
MINTiMINT-393428.
STRINGi4932.YOR372C.

Structurei

3D structure databases

ProteinModelPortaliQ08887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 11318Gln-richAdd
BLAST
Compositional biasi493 – 54654Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG39287.
HOGENOMiHOG000066011.
InParanoidiQ08887.
OMAiELPKMGS.
OrthoDBiEOG78WM4C.

Sequencei

Sequence statusi: Complete.

Q08887-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRDISYQQN YTSTGATATS SRQPSTDNNA DTNFLKVMSE FKYNFNSPLP
60 70 80 90 100
TTTQFPTPYS SNQYQQTQDH FANTDAHNSS SNESSLVENS ILPHHQQIQQ
110 120 130 140 150
QQQQQQQQQQ QQQALGSLVP PAVTRTDTSE TLDDINVQPS SVLQFGNSLP
160 170 180 190 200
SEFLVASPEQ FKEFLLDSPS TNFNFFHKTP AKTPLRFVTD SNGAQQSTTE
210 220 230 240 250
NPGQQQNVFS NVDLNNLLKS NGKTPSSSCT GAFSRTPLSK IDMNLMFNQP
260 270 280 290 300
LPTSPSKRFS SLSLTPYGRK ILNDVGTPYA KALISSNSAL VDFQKARKDI
310 320 330 340 350
TTNATSIGLE NANNILQRTP LRSNNKKLFI KTPQDTINST STLTKDNENK
360 370 380 390 400
QDIYGSSPTT IQLNSSITKS ISKLDNSRIP LLASRSDNIL DSNVDDQLFD
410 420 430 440 450
LGLTRLPLSP TPNCNSLHST TTGTSALQIP ELPKMGSFRS DTGINPISSS
460 470 480 490 500
NTVSFKSKSG NNNSKGRIKK NGKKPSKFQI IVANIDQFNQ DTSSSSLSSS
510 520 530 540 550
LNASSSAGNS NSNVTKKRAS KLKRSQSLLS DSGSKSQARK SCNSKSNGNL

FNSQ
Length:554
Mass (Da):60,523
Last modified:November 1, 1996 - v1
Checksum:i1CF99115F2B1F23D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75280 Genomic DNA. Translation: CAA99703.1.
BK006948 Genomic DNA. Translation: DAA11131.1.
PIRiS67284.
RefSeqiNP_015017.1. NM_001183792.1.

Genome annotation databases

EnsemblFungiiYOR372C; YOR372C; YOR372C.
GeneIDi854554.
KEGGisce:YOR372C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75280 Genomic DNA. Translation: CAA99703.1 .
BK006948 Genomic DNA. Translation: DAA11131.1 .
PIRi S67284.
RefSeqi NP_015017.1. NM_001183792.1.

3D structure databases

ProteinModelPortali Q08887.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34755. 19 interactions.
DIPi DIP-1806N.
IntActi Q08887. 4 interactions.
MINTi MINT-393428.
STRINGi 4932.YOR372C.

Proteomic databases

MaxQBi Q08887.
PaxDbi Q08887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR372C ; YOR372C ; YOR372C .
GeneIDi 854554.
KEGGi sce:YOR372C.

Organism-specific databases

CYGDi YOR372c.
SGDi S000005899. NDD1.

Phylogenomic databases

eggNOGi NOG39287.
HOGENOMi HOG000066011.
InParanoidi Q08887.
OMAi ELPKMGS.
OrthoDBi EOG78WM4C.

Enzyme and pathway databases

BioCyci YEAST:G3O-33840-MONOMER.

Miscellaneous databases

NextBioi 976979.

Gene expression databases

Genevestigatori Q08887.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae."
    Loy C.J., Lydall D., Surana U.
    Mol. Cell. Biol. 19:3312-3327(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  4. "Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters."
    Koranda M., Schleiffer A., Endler L., Ammerer G.
    Nature 406:94-98(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: FUNCTION.
  6. "Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer."
    Sun K., Coic E., Zhou Z., Durrens P., Haber J.E.
    Genes Dev. 16:2085-2096(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECRUITMENT TO PROMOTER.
  7. "Cell cycle-regulated transcription through the FHA domain of Fkh2p and the coactivator Ndd1p."
    Darieva Z., Pic-Taylor A., Boros J., Spanos A., Geymonat M., Reece R.J., Sedgwick S.G., Sharrocks A.D., Morgan B.A.
    Curr. Biol. 13:1740-1745(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  8. "Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation."
    Reynolds D., Shi B.J., McLean C., Katsis F., Kemp B., Dalton S.
    Genes Dev. 17:1789-1802(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FKH2, PHOSPHORYLATION AT THR-319, MUTAGENESIS OF THR-319.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  11. "Inferring yeast cell cycle regulators and interactions using transcription factor activities."
    Yang Y.-L., Suen J., Brynildsen M.P., Galbraith S.J., Liao J.C.
    BMC Genomics 6:90-90(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle."
    Pramila T., Wu W., Miles S., Noble W.S., Breeden L.L.
    Genes Dev. 20:2266-2278(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  13. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDD1_YEAST
AccessioniPrimary (citable) accession number: Q08887
Secondary accession number(s): D6W365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 779 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3