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Q08887

- NDD1_YEAST

UniProt

Q08887 - NDD1_YEAST

Protein

Nuclear division defective protein 1

Gene

NDD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription activator involved in G2/M transcription through its association with FKH2.7 Publications

    GO - Molecular functioni

    1. transcription coactivator activity Source: SGD

    GO - Biological processi

    1. positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33840-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear division defective protein 1
    Gene namesi
    Name:NDD1
    Ordered Locus Names:YOR372C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR372c.
    SGDiS000005899. NDD1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi319 – 3191T → A: Growth delay. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Nuclear division defective protein 1PRO_0000268686Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei319 – 3191Phosphothreonine; by CDC283 Publications

    Post-translational modificationi

    Phosphorylation of Thr-319 by CDC28 is required for the interaction with FKH2 and recruitment to promoters.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ08887.
    PaxDbiQ08887.

    Expressioni

    Inductioni

    During S phase of the cell cycle. Expression is cell cycle regulated by HCM1.2 Publications

    Gene expression databases

    GenevestigatoriQ08887.

    Interactioni

    Subunit structurei

    Forms an activator complex with FKH2.

    Protein-protein interaction databases

    BioGridi34755. 18 interactions.
    DIPiDIP-1806N.
    IntActiQ08887. 4 interactions.
    MINTiMINT-393428.
    STRINGi4932.YOR372C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08887.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi96 – 11318Gln-richAdd
    BLAST
    Compositional biasi493 – 54654Ser-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG39287.
    HOGENOMiHOG000066011.
    OMAiELPKMGS.
    OrthoDBiEOG78WM4C.

    Sequencei

    Sequence statusi: Complete.

    Q08887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRDISYQQN YTSTGATATS SRQPSTDNNA DTNFLKVMSE FKYNFNSPLP    50
    TTTQFPTPYS SNQYQQTQDH FANTDAHNSS SNESSLVENS ILPHHQQIQQ 100
    QQQQQQQQQQ QQQALGSLVP PAVTRTDTSE TLDDINVQPS SVLQFGNSLP 150
    SEFLVASPEQ FKEFLLDSPS TNFNFFHKTP AKTPLRFVTD SNGAQQSTTE 200
    NPGQQQNVFS NVDLNNLLKS NGKTPSSSCT GAFSRTPLSK IDMNLMFNQP 250
    LPTSPSKRFS SLSLTPYGRK ILNDVGTPYA KALISSNSAL VDFQKARKDI 300
    TTNATSIGLE NANNILQRTP LRSNNKKLFI KTPQDTINST STLTKDNENK 350
    QDIYGSSPTT IQLNSSITKS ISKLDNSRIP LLASRSDNIL DSNVDDQLFD 400
    LGLTRLPLSP TPNCNSLHST TTGTSALQIP ELPKMGSFRS DTGINPISSS 450
    NTVSFKSKSG NNNSKGRIKK NGKKPSKFQI IVANIDQFNQ DTSSSSLSSS 500
    LNASSSAGNS NSNVTKKRAS KLKRSQSLLS DSGSKSQARK SCNSKSNGNL 550
    FNSQ 554
    Length:554
    Mass (Da):60,523
    Last modified:November 1, 1996 - v1
    Checksum:i1CF99115F2B1F23D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75280 Genomic DNA. Translation: CAA99703.1.
    BK006948 Genomic DNA. Translation: DAA11131.1.
    PIRiS67284.
    RefSeqiNP_015017.1. NM_001183792.1.

    Genome annotation databases

    EnsemblFungiiYOR372C; YOR372C; YOR372C.
    GeneIDi854554.
    KEGGisce:YOR372C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75280 Genomic DNA. Translation: CAA99703.1 .
    BK006948 Genomic DNA. Translation: DAA11131.1 .
    PIRi S67284.
    RefSeqi NP_015017.1. NM_001183792.1.

    3D structure databases

    ProteinModelPortali Q08887.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34755. 18 interactions.
    DIPi DIP-1806N.
    IntActi Q08887. 4 interactions.
    MINTi MINT-393428.
    STRINGi 4932.YOR372C.

    Proteomic databases

    MaxQBi Q08887.
    PaxDbi Q08887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR372C ; YOR372C ; YOR372C .
    GeneIDi 854554.
    KEGGi sce:YOR372C.

    Organism-specific databases

    CYGDi YOR372c.
    SGDi S000005899. NDD1.

    Phylogenomic databases

    eggNOGi NOG39287.
    HOGENOMi HOG000066011.
    OMAi ELPKMGS.
    OrthoDBi EOG78WM4C.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33840-MONOMER.

    Miscellaneous databases

    NextBioi 976979.

    Gene expression databases

    Genevestigatori Q08887.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae."
      Loy C.J., Lydall D., Surana U.
      Mol. Cell. Biol. 19:3312-3327(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    4. "Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters."
      Koranda M., Schleiffer A., Endler L., Ammerer G.
      Nature 406:94-98(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: FUNCTION.
    6. "Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer."
      Sun K., Coic E., Zhou Z., Durrens P., Haber J.E.
      Genes Dev. 16:2085-2096(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECRUITMENT TO PROMOTER.
    7. "Cell cycle-regulated transcription through the FHA domain of Fkh2p and the coactivator Ndd1p."
      Darieva Z., Pic-Taylor A., Boros J., Spanos A., Geymonat M., Reece R.J., Sedgwick S.G., Sharrocks A.D., Morgan B.A.
      Curr. Biol. 13:1740-1745(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    8. "Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation."
      Reynolds D., Shi B.J., McLean C., Katsis F., Kemp B., Dalton S.
      Genes Dev. 17:1789-1802(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FKH2, PHOSPHORYLATION AT THR-319, MUTAGENESIS OF THR-319.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    11. "Inferring yeast cell cycle regulators and interactions using transcription factor activities."
      Yang Y.-L., Suen J., Brynildsen M.P., Galbraith S.J., Liao J.C.
      BMC Genomics 6:90-90(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle."
      Pramila T., Wu W., Miles S., Noble W.S., Breeden L.L.
      Genes Dev. 20:2266-2278(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    13. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNDD1_YEAST
    AccessioniPrimary (citable) accession number: Q08887
    Secondary accession number(s): D6W365
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 779 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3