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Q08887 (NDD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear division defective protein 1
Gene names
Name:NDD1
Ordered Locus Names:YOR372C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription activator involved in G2/M transcription through its association with FKH2. Ref.3 Ref.4 Ref.5 Ref.7 Ref.8 Ref.11 Ref.12

Subunit structure

Forms an activator complex with FKH2.

Subcellular location

Cytoplasm. Nucleus Ref.3 Ref.9.

Induction

During S phase of the cell cycle. Expression is cell cycle regulated by HCM1. Ref.3 Ref.12

Post-translational modification

Phosphorylation of Thr-319 by CDC28 is required for the interaction with FKH2 and recruitment to promoters.

Miscellaneous

Present with 779 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Nuclear division defective protein 1
PRO_0000268686

Regions

Compositional bias96 – 11318Gln-rich
Compositional bias493 – 54654Ser-rich

Amino acid modifications

Modified residue3191Phosphothreonine; by CDC28 Ref.8 Ref.13

Experimental info

Mutagenesis3191T → A: Growth delay. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q08887 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1CF99115F2B1F23D

FASTA55460,523
        10         20         30         40         50         60 
MDRDISYQQN YTSTGATATS SRQPSTDNNA DTNFLKVMSE FKYNFNSPLP TTTQFPTPYS 

        70         80         90        100        110        120 
SNQYQQTQDH FANTDAHNSS SNESSLVENS ILPHHQQIQQ QQQQQQQQQQ QQQALGSLVP 

       130        140        150        160        170        180 
PAVTRTDTSE TLDDINVQPS SVLQFGNSLP SEFLVASPEQ FKEFLLDSPS TNFNFFHKTP 

       190        200        210        220        230        240 
AKTPLRFVTD SNGAQQSTTE NPGQQQNVFS NVDLNNLLKS NGKTPSSSCT GAFSRTPLSK 

       250        260        270        280        290        300 
IDMNLMFNQP LPTSPSKRFS SLSLTPYGRK ILNDVGTPYA KALISSNSAL VDFQKARKDI 

       310        320        330        340        350        360 
TTNATSIGLE NANNILQRTP LRSNNKKLFI KTPQDTINST STLTKDNENK QDIYGSSPTT 

       370        380        390        400        410        420 
IQLNSSITKS ISKLDNSRIP LLASRSDNIL DSNVDDQLFD LGLTRLPLSP TPNCNSLHST 

       430        440        450        460        470        480 
TTGTSALQIP ELPKMGSFRS DTGINPISSS NTVSFKSKSG NNNSKGRIKK NGKKPSKFQI 

       490        500        510        520        530        540 
IVANIDQFNQ DTSSSSLSSS LNASSSAGNS NSNVTKKRAS KLKRSQSLLS DSGSKSQARK 

       550 
SCNSKSNGNL FNSQ 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae."
Loy C.J., Lydall D., Surana U.
Mol. Cell. Biol. 19:3312-3327(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[4]"Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters."
Koranda M., Schleiffer A., Endler L., Ammerer G.
Nature 406:94-98(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Serial regulation of transcriptional regulators in the yeast cell cycle."
Simon I., Barnett J., Hannett N., Harbison C.T., Rinaldi N.J., Volkert T.L., Wyrick J.J., Zeitlinger J., Gifford D.K., Jaakkola T.S., Young R.A.
Cell 106:697-708(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer."
Sun K., Coic E., Zhou Z., Durrens P., Haber J.E.
Genes Dev. 16:2085-2096(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: RECRUITMENT TO PROMOTER.
[7]"Cell cycle-regulated transcription through the FHA domain of Fkh2p and the coactivator Ndd1p."
Darieva Z., Pic-Taylor A., Boros J., Spanos A., Geymonat M., Reece R.J., Sedgwick S.G., Sharrocks A.D., Morgan B.A.
Curr. Biol. 13:1740-1745(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION.
[8]"Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation."
Reynolds D., Shi B.J., McLean C., Katsis F., Kemp B., Dalton S.
Genes Dev. 17:1789-1802(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FKH2, PHOSPHORYLATION AT THR-319, MUTAGENESIS OF THR-319.
[9]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[11]"Inferring yeast cell cycle regulators and interactions using transcription factor activities."
Yang Y.-L., Suen J., Brynildsen M.P., Galbraith S.J., Liao J.C.
BMC Genomics 6:90-90(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle."
Pramila T., Wu W., Miles S., Noble W.S., Breeden L.L.
Genes Dev. 20:2266-2278(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[13]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z75280 Genomic DNA. Translation: CAA99703.1.
BK006948 Genomic DNA. Translation: DAA11131.1.
PIRS67284.
RefSeqNP_015017.1. NM_001183792.1.

3D structure databases

ProteinModelPortalQ08887.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34755. 17 interactions.
DIPDIP-1806N.
IntActQ08887. 4 interactions.
MINTMINT-393428.
STRING4932.YOR372C.

Proteomic databases

PaxDbQ08887.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR372C; YOR372C; YOR372C.
GeneID854554.
KEGGsce:YOR372C.

Organism-specific databases

CYGDYOR372c.
SGDS000005899. NDD1.

Phylogenomic databases

eggNOGNOG39287.
HOGENOMHOG000066011.
OMAELPKMGS.
OrthoDBEOG78WM4C.

Enzyme and pathway databases

BioCycYEAST:G3O-33840-MONOMER.

Gene expression databases

GenevestigatorQ08887.

Family and domain databases

ProtoNetSearch...

Other

NextBio976979.

Entry information

Entry nameNDD1_YEAST
AccessionPrimary (citable) accession number: Q08887
Secondary accession number(s): D6W365
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD