Reviewed, UniProtKB/Swiss-Prot Q08877 (DYN3_RAT)

Names and origin

Protein names

Recommended name:
    Dynamin-3
    EC=3.6.5.5
Alternative name(s):
    Dynamin, testicular
    T-dynamin

Gene names

Name:	Dnm3
Synonyms:	Dyn3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	869 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
Catalytic activity	GTP + H2O = GDP + phosphate.
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton. Note: Microtubule-associated. Isoform-specific localization. Ref.4 Isoform 2: Cytoplasmic vesicle. Ref.4 Isoform 8: Cytoplasm. Golgi apparatus. Ref.4
Tissue specificity	Isoform-specific expression in germ-cell-depleted testis (Sertoli cells), brain (peripheral sensory neurons), lung and heart. Ref.4 Ref.1
Developmental stage	Up-regulated expression throughout development. Ref.2
Sequence similarities	Belongs to the dynamin family. Contains 1 GED domain. Contains 1 PH domain.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm Cytoplasmic vesicle Cytoskeleton Golgi apparatus Microtubule
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase Motor protein
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	endocytosis Inferred from mutant phenotype. Source: UniProtKB filopodium assembly Inferred from direct assay. Source: UniProtKB sperm ejaculation Non-traceable author statement. Source: UniProtKB synapse assembly Inferred from direct assay. Source: UniProtKB
Cellular component	cytosol Non-traceable author statement. Source: UniProtKB dendritic spine Inferred from direct assay. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from direct assay. Source: UniProtKB postsynaptic density Inferred from direct assay. Source: UniProtKB
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from mutant phenotype. Source: UniProtKB motor activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q08877-1)

Also known as: bab; DynIIIbb;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Expressed in lung, brain, heart.

Isoform 2 (identifier: Q08877-2)

Also known as: baa; DynIIIba;

The sequence of this isoform differs from the canonical sequence as follows:
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart, testis. Localized to vesicular-like punctate spots, neither at the plasma membrane nor the Golgi area.

Isoform 3 (identifier: Q08877-3)

Also known as: bbb;

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → SFGSNKTEM

Note: Expressed in lung, brain, heart, testis.

Isoform 4 (identifier: Q08877-4)

Also known as: bba;

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → SFGSNKTEM
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart.

Isoform 5 (identifier: Q08877-5)

Also known as: bcb;

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → DQAENEDGAQENTF

Note: Expressed in lung.

Isoform 6 (identifier: Q08877-6)

Also known as: bca;

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → DQAENEDGAQENTF
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung.

Isoform 7 (identifier: Q08877-7)

Also known as: aab; DynIIIab;

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.

Note: Expressed in lung, brain, heart, testis.

Isoform 8 (identifier: Q08877-9)

Also known as: aaa; DynIIIaa;

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart, testis. Diffuse cytoplasmic distribution and some modest association with the Golgi apparatus.

Isoform 9 (identifier: Q08877-10)

Also known as: abb;

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → SFGSNKTEM

Note: Expressed in lung, brain, heart.

Isoform 10 (identifier: Q08877-11)

Also known as: aba;

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → SFGSNKTEM
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart.

Isoform 11 (identifier: Q08877-12)

Also known as: acb;

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → DQAENEDGAQENTF

Note: Expressed in lung.

Isoform 12 (identifier: Q08877-13)

Also known as: aca;

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → DQAENEDGAQENTF
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung.

Isoform 13 (identifier: Q08877-8)

Also known as: c;

The sequence of this isoform differs from the canonical sequence as follows:
     526-564: VIRKGWLTVS...SLSWYKDDEE → VRAKFCDSEG...CPHGRKLVLV
     565-869: Missing.

Note: Expressed in lung, brain, heart, testis.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 869	869	Dynamin-3		PRO_0000206574
Regions
	Domain	525 – 631	107	PH
	Domain	659 – 750	92	GED
	Nucleotide binding	38 – 45	8	GTP By similarity
	Nucleotide binding	136 – 140	5	GTP By similarity
	Nucleotide binding	205 – 208	4	GTP By similarity
	Compositional bias	753 – 862	110	Pro-rich
Amino acid modifications
	Modified residue	604	1	N6-acetyllysine By similarity
	Modified residue	769	1	Phosphoserine Ref.3
	Modified residue	773	1	Phosphoserine Ref.3
	Modified residue	853	1	Phosphoserine Ref.3
Natural variations
	Alternative sequence	516 – 525	10	Missing in isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12.		VSP_034038
	Alternative sequence	526 – 564	39	VIRKG…KDDEE → VRAKFCDSEGLADRQQHWHH ERRLEGLLVCPHGRKLVLV in isoform 13.		VSP_034039
	Alternative sequence	565 – 869	305	Missing in isoform 13.		VSP_034040
	Alternative sequence	636 – 640	5	SFTEN → SFGSNKTEM in isoform 3, isoform 4, isoform 9 and isoform 10.		VSP_034041
	Alternative sequence	636 – 640	5	SFTEN → DQAENEDGAQENTF in isoform 5, isoform 6, isoform 11 and isoform 12.		VSP_034042
	Alternative sequence	847 – 869	23	SRRPP…SSLLD → RFGAVKEEAVEP in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12.		VSP_034043

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (bab) (DynIIIbb) [UniParc]. Last modified June 10, 2008. Version 2. Checksum: 00B41E41E5425BAD	FASTA	869	97,914
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM 550 560 570 580 590 600 KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 610 620 630 640 650 660 NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKSFTEN DENGQAENFS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESVE 730 740 750 760 770 780 QAQRRDEMLR MYQALKEALA IIGDINTVTV STPAPPPVDD SWLQHSRRSP PPSPTTQRRL 790 800 810 820 830 840 TLSAPLPRPA SSRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPNSSDSYGA PPQVPSRPTR 850 860 APPSVPSRRP PPSPTRPTII RPLESSLLD
	Isoform 2 (baa) (DynIIIba). Checksum: A54B96E1388DD0CA	FASTA	858	96,660
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM 550 560 570 580 590 600 KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 610 620 630 640 650 660 NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKSFTEN DENGQAENFS MDPQLERQVE 670 680 690 700 710 720 TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESVE 730 740 750 760 770 780 QAQRRDEMLR MYQALKEALA IIGDINTVTV STPAPPPVDD SWLQHSRRSP PPSPTTQRRL 790 800 810 820 830 840 TLSAPLPRPA SSRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPNSSDSYGA PPQVPSRPTR 850 APPSVPRFGA VKEEAVEP
	Isoform 3 (bbb). Checksum: B57DCEFF9E6696DA	FASTA	873	98,318
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM 550 560 570 580 590 600 KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 610 620 630 640 650 660 NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKSFGSN KTEMDENGQA ENFSMDPQLE 670 680 690 700 710 720 RQVETIRNLV DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY SSEDQNTLME 730 740 750 760 770 780 ESVEQAQRRD EMLRMYQALK EALAIIGDIN TVTVSTPAPP PVDDSWLQHS RRSPPPSPTT 790 800 810 820 830 840 QRRLTLSAPL PRPASSRGPA PAIPSPGPHS GAPPVPFRPG PLPPFPNSSD SYGAPPQVPS 850 860 870 RPTRAPPSVP SRRPPPSPTR PTIIRPLESS LLD
	Isoform 4 (bba). Checksum: 3AED72E98B90062E	FASTA	862	97,063
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM 550 560 570 580 590 600 KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 610 620 630 640 650 660 NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKSFGSN KTEMDENGQA ENFSMDPQLE 670 680 690 700 710 720 RQVETIRNLV DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY SSEDQNTLME 730 740 750 760 770 780 ESVEQAQRRD EMLRMYQALK EALAIIGDIN TVTVSTPAPP PVDDSWLQHS RRSPPPSPTT 790 800 810 820 830 840 QRRLTLSAPL PRPASSRGPA PAIPSPGPHS GAPPVPFRPG PLPPFPNSSD SYGAPPQVPS 850 860 RPTRAPPSVP RFGAVKEEAV EP
	Isoform 5 (bcb). Checksum: FD1BCCBFB42A2FD8	FASTA	878	98,885
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM 550 560 570 580 590 600 KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 610 620 630 640 650 660 NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKDQAEN EDGAQENTFD ENGQAENFSM 670 680 690 700 710 720 DPQLERQVET IRNLVDSYMS IINKCIRDLI PKTIMHLMIN NVKDFINSEL LAQLYSSEDQ 730 740 750 760 770 780 NTLMEESVEQ AQRRDEMLRM YQALKEALAI IGDINTVTVS TPAPPPVDDS WLQHSRRSPP 790 800 810 820 830 840 PSPTTQRRLT LSAPLPRPAS SRGPAPAIPS PGPHSGAPPV PFRPGPLPPF PNSSDSYGAP 850 860 870 PQVPSRPTRA PPSVPSRRPP PSPTRPTIIR PLESSLLD
	Isoform 6 (bca). Checksum: B1B5E94CDD159795	FASTA	867	97,631
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM 550 560 570 580 590 600 KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 610 620 630 640 650 660 NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKDQAEN EDGAQENTFD ENGQAENFSM 670 680 690 700 710 720 DPQLERQVET IRNLVDSYMS IINKCIRDLI PKTIMHLMIN NVKDFINSEL LAQLYSSEDQ 730 740 750 760 770 780 NTLMEESVEQ AQRRDEMLRM YQALKEALAI IGDINTVTVS TPAPPPVDDS WLQHSRRSPP 790 800 810 820 830 840 PSPTTQRRLT LSAPLPRPAS SRGPAPAIPS PGPHSGAPPV PFRPGPLPPF PNSSDSYGAP 850 860 PQVPSRPTRA PPSVPRFGAV KEEAVEP
	Isoform 7 (aab) (DynIIIab). Checksum: 43526CBCC8DCA610	FASTA	859	96,850
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV 550 560 570 580 590 600 LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRSLE 610 620 630 640 650 660 LACDSQEDVD SWKASLLRAG VYPDKSFTEN DENGQAENFS MDPQLERQVE TIRNLVDSYM 670 680 690 700 710 720 SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESVE QAQRRDEMLR 730 740 750 760 770 780 MYQALKEALA IIGDINTVTV STPAPPPVDD SWLQHSRRSP PPSPTTQRRL TLSAPLPRPA 790 800 810 820 830 840 SSRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPNSSDSYGA PPQVPSRPTR APPSVPSRRP 850 PPSPTRPTII RPLESSLLD
	Isoform 8 (aaa) (DynIIIaa). Checksum: 802E365FCFC685F6	FASTA	848	95,596
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV 550 560 570 580 590 600 LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRSLE 610 620 630 640 650 660 LACDSQEDVD SWKASLLRAG VYPDKSFTEN DENGQAENFS MDPQLERQVE TIRNLVDSYM 670 680 690 700 710 720 SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESVE QAQRRDEMLR 730 740 750 760 770 780 MYQALKEALA IIGDINTVTV STPAPPPVDD SWLQHSRRSP PPSPTTQRRL TLSAPLPRPA 790 800 810 820 830 840 SSRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPNSSDSYGA PPQVPSRPTR APPSVPRFGA VKEEAVEP
	Isoform 9 (abb). Checksum: 89467DF02D80E427	FASTA	863	97,254
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV 550 560 570 580 590 600 LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRSLE 610 620 630 640 650 660 LACDSQEDVD SWKASLLRAG VYPDKSFGSN KTEMDENGQA ENFSMDPQLE RQVETIRNLV 670 680 690 700 710 720 DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY SSEDQNTLME ESVEQAQRRD 730 740 750 760 770 780 EMLRMYQALK EALAIIGDIN TVTVSTPAPP PVDDSWLQHS RRSPPPSPTT QRRLTLSAPL 790 800 810 820 830 840 PRPASSRGPA PAIPSPGPHS GAPPVPFRPG PLPPFPNSSD SYGAPPQVPS RPTRAPPSVP 850 860 SRRPPPSPTR PTIIRPLESS LLD
	Isoform 10 (aba). Checksum: A79E52BFEEF5A690	FASTA	852	95,999
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV 550 560 570 580 590 600 LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRSLE 610 620 630 640 650 660 LACDSQEDVD SWKASLLRAG VYPDKSFGSN KTEMDENGQA ENFSMDPQLE RQVETIRNLV 670 680 690 700 710 720 DSYMSIINKC IRDLIPKTIM HLMINNVKDF INSELLAQLY SSEDQNTLME ESVEQAQRRD 730 740 750 760 770 780 EMLRMYQALK EALAIIGDIN TVTVSTPAPP PVDDSWLQHS RRSPPPSPTT QRRLTLSAPL 790 800 810 820 830 840 PRPASSRGPA PAIPSPGPHS GAPPVPFRPG PLPPFPNSSD SYGAPPQVPS RPTRAPPSVP 850 RFGAVKEEAV EP
	Isoform 11 (acb). Checksum: F47C9B5D47E6146B	FASTA	868	97,821
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV 550 560 570 580 590 600 LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRSLE 610 620 630 640 650 660 LACDSQEDVD SWKASLLRAG VYPDKDQAEN EDGAQENTFD ENGQAENFSM DPQLERQVET 670 680 690 700 710 720 IRNLVDSYMS IINKCIRDLI PKTIMHLMIN NVKDFINSEL LAQLYSSEDQ NTLMEESVEQ 730 740 750 760 770 780 AQRRDEMLRM YQALKEALAI IGDINTVTVS TPAPPPVDDS WLQHSRRSPP PSPTTQRRLT 790 800 810 820 830 840 LSAPLPRPAS SRGPAPAIPS PGPHSGAPPV PFRPGPLPPF PNSSDSYGAP PQVPSRPTRA 850 860 PPSVPSRRPP PSPTRPTIIR PLESSLLD
	Isoform 12 (aca). Checksum: C348C4D220A8E4B5	FASTA	857	96,566
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQVIRKG WLTVSNIGIM KGGSKGYWFV 550 560 570 580 590 600 LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR NVYKDYRSLE 610 620 630 640 650 660 LACDSQEDVD SWKASLLRAG VYPDKDQAEN EDGAQENTFD ENGQAENFSM DPQLERQVET 670 680 690 700 710 720 IRNLVDSYMS IINKCIRDLI PKTIMHLMIN NVKDFINSEL LAQLYSSEDQ NTLMEESVEQ 730 740 750 760 770 780 AQRRDEMLRM YQALKEALAI IGDINTVTVS TPAPPPVDDS WLQHSRRSPP PSPTTQRRLT 790 800 810 820 830 840 LSAPLPRPAS SRGPAPAIPS PGPHSGAPPV PFRPGPLPPF PNSSDSYGAP PQVPSRPTRA 850 PPSVPRFGAV KEEAVEP
	Isoform 13 (c). Checksum: 2EE4B6A6D27E35CB	FASTA	564	63,927
	10 20 30 40 50 60 MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 70 80 90 100 110 120 SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE IEAETDRVTG MNKGISSVPI 130 140 150 160 170 180 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIRDMI MQFITRENCL ILAVTPANTD 190 200 210 220 230 240 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 250 260 270 280 290 300 DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 310 320 330 340 350 360 QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 370 380 390 400 410 420 KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 430 440 450 460 470 480 KGPSLKSVDL VMQELINTVK KCTKRLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 490 500 510 520 530 540 IQVSYINTNH EDFIGFANAQ QRSSQVHKKS TIGNQGTNLP PSRQIVRAKF CDSEGLADRQ 550 560 QHWHHERRLE GLLVCPHGRK LVLV

References

[1]	"A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis." Nakata T., Takamura R., Hirokawa N. J. Cell Sci. 105:1-5(1993) [PubMed: 8360266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Three dynamin-encoding genes are differentially expressed in developing rat brain." Cook T., Mesa K., Urrutia R. J. Neurochem. 67:927-931(1996) [PubMed: 8752097] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE. Tissue: Brain.
[3]	"The in vivo phosphorylation sites of rat brain dynamin I." Graham M.E., Anggono V., Bache N., Larsen M.R., Craft G.E., Robinson P.J. J. Biol. Chem. 282:14695-14707(2007) [PubMed: 17376771] [Abstract] Cited for: PROTEIN SEQUENCE OF 839-859 (ISOFORM 1/3/5/7/9/11), PHOSPHORYLATION AT SER-769; SER-773 AND SER-853, MASS SPECTROMETRY.
[4]	"Differential distribution of dynamin isoforms in mammalian cells." Cao H., Garcia F., McNiven M.A. Mol. Biol. Cell 9:2595-2609(1998) [PubMed: 9725914] [Abstract] Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D14076 mRNA. Translation: BAA03161.1. AF201839 mRNA. Translation: AAF07848.1.
IPI	IPI00213318. IPI00325049. IPI00561570. IPI00896116. IPI00896122. IPI00896138. IPI00896146. IPI00896159. IPI00896171. IPI00896177. IPI00896185. IPI00896200. IPI00896232.
PIR	I55498.
RefSeq	NP_612547.1.
UniGene	Rn.11191
3D structure databases
HSSP	HSSP built from PDB template 2DYN based on UniProtKB Q05193.
SMR	Q08877. Positions 6-304, 516-625.
ModBase	Search...
Protein-protein interaction databases
STRING	Q08877.
PTM databases
PhosphoSite	Q08877.
Genome annotation databases
Ensembl	ENSRNOT00000011110; ENSRNOP00000011110; ENSRNOG00000026490; Rattus norvegicus. [Genome view] ENSRNOT00000047799; ENSRNOP00000041640; ENSRNOG00000026490; Rattus norvegicus. [Genome view]
GeneID	171574.
KEGG	rno:171574.
UCSC	D14076. rat.
Organism-specific databases
CTD	171574.
RGD	727949. Dnm3.
Phylogenomic databases
HOVERGEN	Q08877.
Enzyme and pathway databases
BRENDA	3.6.5.5. 248.
Gene expression databases
ArrayExpress	Q08877.
Genevestigator	Q08877.
GermOnline	ENSRNOG00000026490. Rattus norvegicus.
Family and domain databases
InterPro	IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR003130. GED. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS00410. DYNAMIN. 1 hit. PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	622598.

Entry information

Entry name

DYN3_RAT

Accession

Primary (citable) accession number: Q08877
Secondary accession number(s): Q9QXL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	June 10, 2008
Last modified:	November 3, 2009
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)