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Q08873

- SCP1_YEAST

UniProt

Q08873 - SCP1_YEAST

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Protein
Transgelin
Gene
SCP1, YOR367W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has actin-binding and actin-bundling activity. Stabilizes actin filaments against disassembly.

GO - Molecular functioni

  1. actin filament binding Source: SGD
  2. protein binding Source: IntAct
  3. protein binding, bridging Source: SGD

GO - Biological processi

  1. actin filament organization Source: SGD
  2. chronological cell aging Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33835-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
Calponin homolog 1
Gene namesi
Name:SCP1
Ordered Locus Names:YOR367W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR367w.
SGDiS000005894. SCP1.

Subcellular locationi

Cytoplasmcytoskeletonactin patch
Note: Cortical actin patches.3 Publications

GO - Cellular componenti

  1. actin cortical patch Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi185 – 1851S → A: Greatly reduces actin-binding and actin-bundling activity. 1 Publication
Mutagenesisi185 – 1851S → D: Moderately reduces actin-binding and actin-bundling activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 200199Transgelin
PRO_0000204795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei11 – 111Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ08873.
PaxDbiQ08873.

Expressioni

Gene expression databases

GenevestigatoriQ08873.

Interactioni

Subunit structurei

Binds to actin. Interacts with ABP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABP1P158916EBI-33137,EBI-2036

Protein-protein interaction databases

BioGridi34750. 11 interactions.
DIPiDIP-6340N.
IntActiQ08873. 2 interactions.
MINTiMINT-686883.
STRINGi4932.YOR367W.

Structurei

3D structure databases

ProteinModelPortaliQ08873.
SMRiQ08873. Positions 22-157.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 136111CH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 16414Interaction with SH3 domain of ABP1
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5199.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
OMAiLNLQMGF.
OrthoDBiEOG754J1V.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08873-1 [UniParc]FASTAAdd to Basket

« Hide

MSYDKKADVT SLDEDLRQLR ESKFSPEAIQ NIKIWVYKSV LKEIAPPGDL    50
LECLKDGTVL CKLANILYEA DTGEANHISW KSSKMPFVQM DQISQFLSFS 100
RKYGVPEDEL FQTIDLFEKK DPAIVFQTLK SLSRYANKKH TDRFPVLGPQ 150
LSTKKPRPPV KSKPKHLQDG TGWSTFEYGY MKGASQATEG VVLGQRRDIV 200
Length:200
Mass (Da):22,748
Last modified:November 1, 1996 - v1
Checksum:i6C8E7EACCFD0DE28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75275 Genomic DNA. Translation: CAA99698.1.
BK006948 Genomic DNA. Translation: DAA11126.1.
PIRiS67279.
RefSeqiNP_015012.3. NM_001183787.3.

Genome annotation databases

EnsemblFungiiYOR367W; YOR367W; YOR367W.
GeneIDi854549.
KEGGisce:YOR367W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75275 Genomic DNA. Translation: CAA99698.1 .
BK006948 Genomic DNA. Translation: DAA11126.1 .
PIRi S67279.
RefSeqi NP_015012.3. NM_001183787.3.

3D structure databases

ProteinModelPortali Q08873.
SMRi Q08873. Positions 22-157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34750. 11 interactions.
DIPi DIP-6340N.
IntActi Q08873. 2 interactions.
MINTi MINT-686883.
STRINGi 4932.YOR367W.

Proteomic databases

MaxQBi Q08873.
PaxDbi Q08873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR367W ; YOR367W ; YOR367W .
GeneIDi 854549.
KEGGi sce:YOR367W.

Organism-specific databases

CYGDi YOR367w.
SGDi S000005894. SCP1.

Phylogenomic databases

eggNOGi COG5199.
GeneTreei ENSGT00550000074447.
HOGENOMi HOG000232113.
OMAi LNLQMGF.
OrthoDBi EOG754J1V.

Enzyme and pathway databases

BioCyci YEAST:G3O-33835-MONOMER.

Miscellaneous databases

NextBioi 976964.
PROi Q08873.

Gene expression databases

Genevestigatori Q08873.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
InterProi IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
[Graphical view ]
PRINTSi PR00888. SM22CALPONIN.
SMARTi SM00033. CH. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
PROSITEi PS50021. CH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. "SCP1 encodes an actin-bundling protein in yeast."
    Winder S.J., Jess T., Ayscough K.R.
    Biochem. J. 375:287-295(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTIN, SUBCELLULAR LOCATION.
  5. "The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton."
    Goodman A., Goode B.L., Matsudaira P., Fink G.R.
    Mol. Biol. Cell 14:2617-2629(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTIN, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-185.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: INTERACTION WITH ABP1.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCP1_YEAST
AccessioniPrimary (citable) accession number: Q08873
Secondary accession number(s): D6W360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1578 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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