Reviewed, UniProtKB/Swiss-Prot Q08863 (GSTA1_RABIT)

Names and origin

Protein names	Recommended name:     Glutathione S-transferase alpha I     EC=2.5.1.18 Alternative name(s):     GSTA1-1     GST class-alpha
Organism	Oryctolagus cuniculus (Rabbit)
Taxonomic identifier	9986 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Liver and lung.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Glutathione S-transferase alpha I		PRO_0000185798
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q08863-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 893027DA39FC6840	FASTA	223	25,691
	10 20 30 40 50 60 MARKPLLHYF NGRGRMESIR WLLAAAGEEF DEKFMETAED LDKLRNDGSL MYQQVPMVEI 70 80 90 100 110 120 DGMKLVQTRA ILNYVANKHN LYGKDMKERA LIDMYTEGVA DLYELVLLLP LCPPEQKDAK 130 140 150 160 170 180 VDFIKEKIRT RYFPAFEKVL KSHGQDYLVG NRLSKADILL VELLYNVEEL DPSAIASFPL 190 200 210 220 LKALKTRISS LPTVKKFLQP GSQRKPPMDE KNLEKAKKIF KIP

References

[1]

"The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation." Gardlik S.J., Gasser R., Philpot R.M., Serabjit-Singh C.J. J. Biol. Chem. 266:19681-19687(1991) [PubMed: 1918075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: New Zealand white. Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M74528 mRNA. Translation: AAA31259.1.
PIR	A41031.
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
SMR	Q08863. Positions 2-221.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q08863.
Enzyme and pathway databases
BRENDA	2.5.1.18. 255.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11571:SF4. GST_alpha. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTA1_RABIT

Accession

Primary (citable) accession number: Q08863

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)