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Protein

Glutathione S-transferase alpha I

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase alpha I (EC:2.5.1.18)
Alternative name(s):
GST class-alpha
GSTA1-1
Cleaved into the following chain:
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 12

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217831 – 223Glutathione S-transferase alpha IAdd BLAST223
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00001857982 – 223Glutathione S-transferase alpha I, N-terminally processedAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Glutathione S-transferase alpha I, N-terminally processedBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Liver and lung.

Gene expression databases

BgeeiENSOCUG00000003679.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003188.

Structurei

3D structure databases

ProteinModelPortaliQ08863.
SMRiQ08863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
KOiK00799.
OMAiNEMIIVL.
OrthoDBiEOG091G0O3D.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKPLLHYF NGRGRMESIR WLLAAAGEEF DEKFMETAED LDKLRNDGSL
60 70 80 90 100
MYQQVPMVEI DGMKLVQTRA ILNYVANKHN LYGKDMKERA LIDMYTEGVA
110 120 130 140 150
DLYELVLLLP LCPPEQKDAK VDFIKEKIRT RYFPAFEKVL KSHGQDYLVG
160 170 180 190 200
NRLSKADILL VELLYNVEEL DPSAIASFPL LKALKTRISS LPTVKKFLQP
210 220
GSQRKPPMDE KNLEKAKKIF KIP
Length:223
Mass (Da):25,691
Last modified:November 1, 1995 - v1
Checksum:i893027DA39FC6840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74528 mRNA. Translation: AAA31259.1.
PIRiA41031.
RefSeqiNP_001164568.1. NM_001171097.1.
UniGeneiOcu.6221.

Genome annotation databases

EnsembliENSOCUT00000003678; ENSOCUP00000003188; ENSOCUG00000003679.
GeneIDi100328910.
KEGGiocu:100328910.

Similar proteinsi

Entry informationi

Entry nameiGSTA1_RABIT
AccessioniPrimary (citable) accession number: Q08863
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families