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Q08863

- GSTA1_RABIT

UniProt

Q08863 - GSTA1_RABIT

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Protein

Glutathione S-transferase alpha I

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase alpha I (EC:2.5.1.18)
Alternative name(s):
GST class-alpha
GSTA1-1
Cleaved into the following chain:
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Glutathione S-transferase alpha IPRO_0000185798Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 223222Glutathione S-transferase alpha I, N-terminally processedPRO_0000421783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Liver and lung.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003188.

Structurei

3D structure databases

ProteinModelPortaliQ08863.
SMRiQ08863. Positions 2-221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione binding By similarity
Regioni67 – 682Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08863-1 [UniParc]FASTAAdd to Basket

« Hide

MARKPLLHYF NGRGRMESIR WLLAAAGEEF DEKFMETAED LDKLRNDGSL    50
MYQQVPMVEI DGMKLVQTRA ILNYVANKHN LYGKDMKERA LIDMYTEGVA 100
DLYELVLLLP LCPPEQKDAK VDFIKEKIRT RYFPAFEKVL KSHGQDYLVG 150
NRLSKADILL VELLYNVEEL DPSAIASFPL LKALKTRISS LPTVKKFLQP 200
GSQRKPPMDE KNLEKAKKIF KIP 223
Length:223
Mass (Da):25,691
Last modified:November 1, 1995 - v1
Checksum:i893027DA39FC6840
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74528 mRNA. Translation: AAA31259.1.
PIRiA41031.
RefSeqiNP_001164568.1. NM_001171097.1.
UniGeneiOcu.6221.

Genome annotation databases

EnsembliENSOCUT00000003678; ENSOCUP00000003188; ENSOCUG00000003679.
GeneIDi100328910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74528 mRNA. Translation: AAA31259.1 .
PIRi A41031.
RefSeqi NP_001164568.1. NM_001171097.1.
UniGenei Ocu.6221.

3D structure databases

ProteinModelPortali Q08863.
SMRi Q08863. Positions 2-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000003188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000003678 ; ENSOCUP00000003188 ; ENSOCUG00000003679 .
GeneIDi 100328910.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation."
    Gardlik S.J., Gasser R., Philpot R.M., Serabjit-Singh C.J.
    J. Biol. Chem. 266:19681-19687(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: New Zealand white.
    Tissue: Lung.

Entry informationi

Entry nameiGSTA1_RABIT
AccessioniPrimary (citable) accession number: Q08863
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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