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Q08863 (GSTA1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase alpha I

EC=2.5.1.18
Alternative name(s):
GST class-alpha
GSTA1-1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Liver and lung.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Glutathione S-transferase alpha I
PRO_0000185798
Initiator methionine11Removed; alternate By similarity
Chain2 – 223222Glutathione S-transferase alpha I, N-terminally processed
PRO_0000421783

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal
Region54 – 552Glutathione binding By similarity
Region67 – 682Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity
Binding site451Glutathione By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08863 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 893027DA39FC6840

FASTA22325,691
        10         20         30         40         50         60 
MARKPLLHYF NGRGRMESIR WLLAAAGEEF DEKFMETAED LDKLRNDGSL MYQQVPMVEI 

        70         80         90        100        110        120 
DGMKLVQTRA ILNYVANKHN LYGKDMKERA LIDMYTEGVA DLYELVLLLP LCPPEQKDAK 

       130        140        150        160        170        180 
VDFIKEKIRT RYFPAFEKVL KSHGQDYLVG NRLSKADILL VELLYNVEEL DPSAIASFPL 

       190        200        210        220 
LKALKTRISS LPTVKKFLQP GSQRKPPMDE KNLEKAKKIF KIP 

« Hide

References

[1]"The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation."
Gardlik S.J., Gasser R., Philpot R.M., Serabjit-Singh C.J.
J. Biol. Chem. 266:19681-19687(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: New Zealand white.
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74528 mRNA. Translation: AAA31259.1.
PIRA41031.
RefSeqNP_001164568.1. NM_001171097.1.
UniGeneOcu.6221.

3D structure databases

ProteinModelPortalQ08863.
SMRQ08863. Positions 2-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000003188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000003678; ENSOCUP00000003188; ENSOCUG00000003679.
GeneID100328910.

Phylogenomic databases

eggNOGNOG266414.
GeneTreeENSGT00670000097856.
HOGENOMHOG000115734.
HOVERGENHBG053749.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTA1_RABIT
AccessionPrimary (citable) accession number: Q08863
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families